PMID- 38485992
OWN - NLM
STAT- MEDLINE
DCOM- 20240318
LR  - 20240426
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 14
IP  - 1
DP  - 2024 Mar 14
TI  - Deprescribing potential of commonly used medications among community-dwelling 
      older adults: insights from a pharmacist's geriatric assessment.
PG  - 6235
LID - 10.1038/s41598-024-56780-1 [doi]
LID - 6235
AB  - Pharmacist's geriatric assessment can provide valuable insights into potential 
      deprescribing targets, while including important information on various 
      health-related domains. Data collected from a geriatric assessment questionnaire, 
      for 388 patients, from the Croatian cohort of the EuroAgeism H2020 ESR 7 
      international project, along with guideline-based deprescribing criteria, were 
      used to analyse potentially inappropriate prescribing of four medication groups 
      (benzodiazepines (BZN), proton pump inhibitors (PPI), opioids, and non-steroidal 
      anti-inflammatory drugs (NSAID)), and to assess the deprescribing potential. 
      Binary logistic regression was used to explore the effects of age, gender, number 
      of medicines and diagnoses, self-reported health, frailty score, and healthcare 
      utilization on the likelihood of needing deprescribing. More than half of 
      participants (n = 216, 55.2%) are candidates for deprescribing, with 31.1% of 
      PPI, 74.8% of NSAID, 75% of opioid, and 96.1% of BZN users meeting at least one 
      criterion. Most common criteria for deprescribing were inappropriately long use 
      and safety concerns. Women (aOR = 2.58; p < 0.001), those reporting poor 
      self-reported health (aOR = 5.14; p < 0.001), and those exposed to polypharmacy 
      (aOR = 1.29; p < 0.001) had higher odds of needing to have medicines 
      deprescribed. The high rate of deprescribing potential warrants prompt action to 
      increase patient safety and decrease polypharmacy. Pharmacist's geriatric 
      assessment and deprescribing-focused medication review could be used to lead a 
      personalised approach.
CI  - (c) 2024. The Author(s).
FAU - Buzancic, Iva
AU  - Buzancic I
AUID- ORCID: 0000-0002-4140-8657
AD  - City Pharmacies Zagreb, Kralja Drzislava 6, Zagreb, Croatia.
AD  - Faculty of Pharmacy and Biochemistry, Center for Applied Pharmacy, University of 
      Zagreb, Ante Kovacica 1, 10 000, Zagreb, Croatia.
FAU - Drzaic, Margita
AU  - Drzaic M
AUID- ORCID: 0000-0002-1539-4482
AD  - City Pharmacies Zagreb, Kralja Drzislava 6, Zagreb, Croatia.
AD  - Faculty of Pharmacy and Biochemistry, Center for Applied Pharmacy, University of 
      Zagreb, Ante Kovacica 1, 10 000, Zagreb, Croatia.
FAU - Kummer, Ingrid
AU  - Kummer I
AUID- ORCID: 0000-0003-0205-1576
AD  - Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec 
      Kralove, Charles University, Akademika Heyrovskeho 1203/8, Hradec Kralove, 
      Prague, Czech Republic.
FAU - Ortner Hadziabdic, Maja
AU  - Ortner Hadziabdic M
AUID- ORCID: 0000-0003-1578-9764
AD  - Faculty of Pharmacy and Biochemistry, Center for Applied Pharmacy, University of 
      Zagreb, Ante Kovacica 1, 10 000, Zagreb, Croatia. mortner@pharma.hr.
FAU - Brkic, Jovana
AU  - Brkic J
AD  - Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec 
      Kralove, Charles University, Akademika Heyrovskeho 1203/8, Hradec Kralove, 
      Prague, Czech Republic.
AD  - Department of Social Pharmacy and Pharmaceutical Legislation, Faculty of 
      Pharmacy, University of Belgrade, 450 Vojvode Stepe Street, Belgrade, Serbia.
FAU - Fialova, Daniela
AU  - Fialova D
AUID- ORCID: 0000-0001-5638-9690
AD  - Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec 
      Kralove, Charles University, Akademika Heyrovskeho 1203/8, Hradec Kralove, 
      Prague, Czech Republic.
AD  - Department of Geriatrics and Gerontology, 1st Faculty of Medicine in Prague, 
      Charles University, Katerinska 32, Prague, Czech Republic.
LA  - eng
GR  - MSCF-ITN-764632/Marie Sklodowska-Curie Foundation/
GR  - No CZ.02.1.01/0.0/0.0/18_069/0010046/InoMed/
GR  - No 965341, START / MED / 093 EN.02.2.69 / 0.0 / 0.0 / 19_073 / 0016935, SVV 260 
      551/European Horizon 2020 I-CARE4OLD/
GR  - Research Unit: "Ageing, Polypharmacotherapy and Changes in Therapeutic Value of 
      Drugs in the Aged'', KSKF-I./Cooperatio research program of the Faculty of 
      Pharmacy, Charles University/
GR  - CZ.02.01.01/00/22_008/0004607/NETPHARM project/
PT  - Journal Article
DEP - 20240314
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
SB  - IM
EIN - Sci Rep. 2024 Apr 22;14(1):9236. PMID: 38649739
MH  - Humans
MH  - Female
MH  - Aged
MH  - *Deprescriptions
MH  - Geriatric Assessment
MH  - Independent Living
MH  - Pharmacists
MH  - Inappropriate Prescribing/prevention & control
MH  - Anti-Inflammatory Agents, Non-Steroidal
PMC - PMC10940601
OTO - NOTNLM
OT  - Deprescribing
OT  - Geriatric assessment
OT  - Geriatrics
OT  - Healthy ageing
OT  - Polypharmacy
COIS- The authors declare no competing interests.
EDAT- 2024/03/15 06:43
MHDA- 2024/03/18 06:43
PMCR- 2024/03/14
CRDT- 2024/03/15 00:31
PHST- 2023/11/18 00:00 [received]
PHST- 2024/03/11 00:00 [accepted]
PHST- 2024/03/18 06:43 [medline]
PHST- 2024/03/15 06:43 [pubmed]
PHST- 2024/03/15 00:31 [entrez]
PHST- 2024/03/14 00:00 [pmc-release]
AID - 10.1038/s41598-024-56780-1 [pii]
AID - 56780 [pii]
AID - 10.1038/s41598-024-56780-1 [doi]
PST - epublish
SO  - Sci Rep. 2024 Mar 14;14(1):6235. doi: 10.1038/s41598-024-56780-1.