PMID- 38486737
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240316
IS  - 2405-8440 (Print)
IS  - 2405-8440 (Electronic)
IS  - 2405-8440 (Linking)
VI  - 10
IP  - 5
DP  - 2024 Mar 15
TI  - Serum ferritin is associated with the presence of ischemic stroke among 
      individuals with type 2 diabetes.
PG  - e27898
LID - 10.1016/j.heliyon.2024.e27898 [doi]
LID - e27898
AB  - BACKGROUND: Epidemiological evidence regarding the possible link between serum 
      ferritin (SF) level and ischemic stroke risk among individuals with type 2 
      diabetes mellitus (T2DM) is sparse. AIM: To evaluate the association between SF 
      level in plasma and ischemic stroke risk among individuals with T2DM. METHODS: SF 
      levels were measured in 210 T2DM patients with (n = 165) or without ischemic 
      stroke (n = 45). Multivariate logistic regression analyses were used to estimate 
      odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: The SF level of 
      T2DM patients with ischemic stroke was significantly higher than that of patients 
      without ischemic stroke (P = 0.003). The multivariate logistic regression 
      analyses revealed that each 1-SD increase in SF (OR: 1.92; 95%CI: 1.22, 3.03) was 
      significantly associated with increased ischemic stroke risk among T2DM patients. 
      In addition, interaction effect of SF and BMI on ischemic stroke risk were also 
      observed (P(for interaction) = 0.037). CONCLUSIONS: Higher levels of SF were 
      independently associated with increased risk of ischemic stroke among individuals 
      with T2DM.
CI  - (c) 2024 The Authors. Published by Elsevier Ltd.
FAU - Zhang, Youyou
AU  - Zhang Y
AD  - Department of Geriatric Neurology, The Second Affiliated Hospital of Xi'an 
      Jiaotong University, No. 157 Xi'wu Road, Xi'an, 710004, Shaanxi, China.
FAU - Wang, Hui
AU  - Wang H
AD  - Department of Geriatric Neurology, The Second Affiliated Hospital of Xi'an 
      Jiaotong University, No. 157 Xi'wu Road, Xi'an, 710004, Shaanxi, China.
FAU - Jia, Ruirui
AU  - Jia R
AD  - Department of Geriatric Neurology, The Second Affiliated Hospital of Xi'an 
      Jiaotong University, No. 157 Xi'wu Road, Xi'an, 710004, Shaanxi, China.
FAU - Chen, Dong
AU  - Chen D
AD  - Department of Clinical Laboratory, The Second Affiliated Hospital of Xi'an 
      Jiaotong University, No. 157 Xi'wu Road, Xi'an, 710004, Shaanxi, China.
FAU - Li, Zhaoyang
AU  - Li Z
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      Xi'an Jiaotong University, No. 76 West Yanta Road, Xi'an, 710061, Shaanxi, China.
LA  - eng
PT  - Journal Article
DEP - 20240308
PL  - England
TA  - Heliyon
JT  - Heliyon
JID - 101672560
PMC - PMC10938112
OTO - NOTNLM
OT  - Ischemic stroke
OT  - Serum ferritin
OT  - Type 2 diabetes mellitus
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2024/03/15 06:43
MHDA- 2024/03/15 06:44
PMCR- 2024/03/08
CRDT- 2024/03/15 03:56
PHST- 2023/09/06 00:00 [received]
PHST- 2024/03/03 00:00 [revised]
PHST- 2024/03/07 00:00 [accepted]
PHST- 2024/03/15 06:44 [medline]
PHST- 2024/03/15 06:43 [pubmed]
PHST- 2024/03/15 03:56 [entrez]
PHST- 2024/03/08 00:00 [pmc-release]
AID - S2405-8440(24)03929-X [pii]
AID - e27898 [pii]
AID - 10.1016/j.heliyon.2024.e27898 [doi]
PST - epublish
SO  - Heliyon. 2024 Mar 8;10(5):e27898. doi: 10.1016/j.heliyon.2024.e27898. eCollection 
      2024 Mar 15.