PMID- 38486768
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240316
IS  - 2405-8440 (Print)
IS  - 2405-8440 (Electronic)
IS  - 2405-8440 (Linking)
VI  - 10
IP  - 5
DP  - 2024 Mar 15
TI  - Antiobesity and antidiabetes effects of Cyperus rotundus rhizomes presenting 
      protein tyrosine phosphatase, dipeptidyl peptidase 4, metabolic enzymes, stress 
      oxidant and inflammation inhibitory potential.
PG  - e27598
LID - 10.1016/j.heliyon.2024.e27598 [doi]
LID - e27598
AB  - Diabetes is a significant global health concern that increases the vulnerability 
      to various chronic illnesses. In view of this issue, the current research aimed 
      to examine the effects of administering an extract derived from the tubers of 
      Cyperus rotundus L (CrE) on obesity, type 1 diabetes, and liver-kidney toxicity. 
      Through the utilization of HPLC-DAD analysis, it was discovered that the extract 
      contained several components, including quercetin (47.8%), luteolin glucoside 
      (17%), luteolin (7.56%), apigenin-7-glucoside (6.29%), naringinin (4.52%), and 
      seven others. In vitro experiments they have demonstrated that CrE effectively 
      inhibited key digestive enzymes associated with obesity and type 2 diabetes, such 
      as DPP-4, PTP1B, lipase, and alpha-amylase, as evidenced by their respective IC50 
      values are about 23, 51,83, and 67 mug/ml respectively. Furthermore, when diabetic 
      rats were administered CrE, the activity of pancreatic enzymes linked to 
      inflammation, namely 5-lipoxygenase (5-LO), hyaluronidase (HAase), and 
      myeloperoxidase (MPO), was significantly suppressed by 48, 41, 75, and 47%, 
      respectively. Moreover, CrE exhibited protective effects on pancreatic beta-cells by 
      inhibiting the formation of thiobarbituric acid reactive substances (TBARS) by 
      65% and the induction of superoxide Dismutase (SOD), catalase (CAT) and 
      glutathione peroxidase (GPX) activities by 62, 108, and 112% respectively as 
      compared to diabetic untreated rat. Additionally, CrE significantly inhibited the 
      activities of intestinal, pancreatic, and serum lipase and alpha-amylase activities. 
      In diabetic rats, CrE administration suppressed glycogen phosphorylase (GP) 
      stimulated glycogen synthase (GS) activities by 45 and 30%; and this increased 
      liver glycogen content by 45%. Furthermore, CrE modulated key hepatic enzymes 
      involved in carbohydrate metabolism, including hexokinase (HK), 
      glucose-6-phosphate dehydrogenase (G6PD), glucose-6-phosphatase (G6P), and 
      fructose-1,6-bisphosphatase (FBP). Notably, the average food and water intake 
      (AFI and AWI) of diabetic rats treated with CrE was reduced by 15 and 16% 
      respectively as compared to those without any treatment. Therefore, this study 
      demonstrated the effectiveness of Cyperus rotundus tubers in preventing and 
      treating obesity and diabetes.
CI  - (c) 2024 The Authors.
FAU - Abdella, Faiza I A
AU  - Abdella FIA
AD  - Department of Chemistry, College of Science, Ha'il University, Ha'il, 81451, 
      Saudi Arabia.
FAU - Toumi, Amani
AU  - Toumi A
AD  - Laboratory of Heterocyclic Chemistry Natural Product and Reactivity (LR11ES39), 
      Department of Chemistry, Faculty of Science of Monastir, University of Monastir, 
      Monastir, 5019, Tunisia.
FAU - Boudriga, Sarra
AU  - Boudriga S
AD  - Laboratory of Heterocyclic Chemistry Natural Product and Reactivity (LR11ES39), 
      Department of Chemistry, Faculty of Science of Monastir, University of Monastir, 
      Monastir, 5019, Tunisia.
FAU - Alanazi, Tahani Y A
AU  - Alanazi TYA
AD  - Department of Chemistry, College of Science, Ha'il University, Ha'il, 81451, 
      Saudi Arabia.
FAU - Alshamari, Asma K
AU  - Alshamari AK
AD  - Department of Chemistry, College of Science, Ha'il University, Ha'il, 81451, 
      Saudi Arabia.
FAU - Alrashdi, Ahlam Abdulrahman
AU  - Alrashdi AA
AD  - Department of Chemistry, College of Science, Ha'il University, Ha'il, 81451, 
      Saudi Arabia.
FAU - Hamden, Khaled
AU  - Hamden K
AD  - Laboratory of Bioresources: Integrative Biology and Valorization, Higher 
      Institute of Biotechnology of Monastir, University of Monastir, Monastir, 5000, 
      Tunisia.
LA  - eng
PT  - Journal Article
DEP - 20240305
PL  - England
TA  - Heliyon
JT  - Heliyon
JID - 101672560
PMC - PMC10937842
OTO - NOTNLM
OT  - Cyperus rotundus
OT  - Diabetes
OT  - Disacchridases
OT  - Inflammation
OT  - Obesity
OT  - Pancreas
COIS- The authors declare the following financial interests/personal relationships 
      which may be considered as potential competing interests.
EDAT- 2024/03/15 06:44
MHDA- 2024/03/15 06:45
PMCR- 2024/03/05
CRDT- 2024/03/15 03:56
PHST- 2023/11/27 00:00 [received]
PHST- 2024/03/03 00:00 [revised]
PHST- 2024/03/04 00:00 [accepted]
PHST- 2024/03/15 06:45 [medline]
PHST- 2024/03/15 06:44 [pubmed]
PHST- 2024/03/15 03:56 [entrez]
PHST- 2024/03/05 00:00 [pmc-release]
AID - S2405-8440(24)03629-6 [pii]
AID - e27598 [pii]
AID - 10.1016/j.heliyon.2024.e27598 [doi]
PST - epublish
SO  - Heliyon. 2024 Mar 5;10(5):e27598. doi: 10.1016/j.heliyon.2024.e27598. eCollection 
      2024 Mar 15.