PMID- 38487144
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240316
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 16
IP  - 2
DP  - 2024 Feb
TI  - Adverse Effects of Cancer Treatment in Patients With Cervical Cancer.
PG  - e54106
LID - 10.7759/cureus.54106 [doi]
LID - e54106
AB  - BACKGROUND: In lower- to middle-income countries such as India, the literature on 
      the adverse effects (AEs) of cancer treatment in patients with cervical cancer is 
      very limited. This knowledge gap provides an opportunity to investigate and 
      improve the quality of life for women with cervical cancer. OBJECTIVE: The 
      purpose of this study was to assess the AEs of various cancer treatment 
      combinations in patients with cervical cancer. METHODS: This observational, 
      retrospective study analysed 1,030 women with cervical cancer, with a descriptive 
      cross-sectional design, based on a review of medical records from patients who 
      were followed up during the morbidity consultation conducted by a 
      multidisciplinary team of doctors. The AEs of cancer treatment for women with 
      cervical cancer were recorded in these medical records between October 14, 2019, 
      and November 21, 2022, at 10 major public tertiary hospitals in India. RESULTS: 
      This study analysed 1,030 women with cervical cancer aged between 21 and 80 years 
      (mean age: 48.8 +/- 13.9 years; p=0.30). Patients between the ages of 36-50 years 
      reported the most AEs (30.2%; 95% confidence interval (CI): 29.1-32.8) among 
      other age groups. Combined radiation therapy and chemotherapy (CT) was the type 
      of cancer treatment in which there were more AEs, presenting in 56.0% (95% CI: 
      55-60.1) of patients. Adverse effects associated with the gastrointestinal system 
      were observed in the majority (92.5%, 95% CI: 90.2-96.9) of cervical cancer 
      patients. CONCLUSION: Exposure to different cancer treatments, particularly 
      combination therapy, induces AEs in patients during and after cervical cancer 
      treatment.
CI  - Copyright (c) 2024, Palagudi et al.
FAU - Palagudi, Mahesh
AU  - Palagudi M
AD  - Department of General Medicine, P.E.S. Institute of Medical Sciences and 
      Research, Kuppam, IND.
FAU - Para, Sneha
AU  - Para S
AD  - Department of General Medicine, Maheshwara Medical College and Hospital, 
      Hyderabad, IND.
FAU - Golla, Nagasree
AU  - Golla N
AD  - Department of General Medicine, I. K. Akhunbaev Kyrgyz State Medical Academy, 
      Bishkek, KGZ.
FAU - Meduri, Krishna Chaitanya
AU  - Meduri KC
AD  - Department of General Medicine, Maheshwara Medical College and Hospital, 
      Hyderabad, IND.
FAU - Duvvuri, Sai Praneeth
AU  - Duvvuri SP
AD  - Department of General Medicine, Maheshwara Medical College and Hospital, 
      Hyderabad, IND.
FAU - Vityala, Yethindra
AU  - Vityala Y
AD  - Department of Research, AJ Research Centre, AJ Institute of Medical Sciences and 
      Research Centre, Mangalore, IND.
AD  - Department of Pathology, International Higher School of Medicine, International 
      University of Kyrgyzstan, Bishkek, KGZ.
FAU - Sajja, Deepika Chowdary
AU  - Sajja DC
AD  - Department of General Medicine, Santhiram Medical College, Tirupati, IND.
FAU - Damineni, Ujwala
AU  - Damineni U
AD  - Department of General Medicine, Maheshwara Medical College and Hospital, 
      Hyderabad, IND.
LA  - eng
PT  - Journal Article
DEP - 20240213
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC10938271
OTO - NOTNLM
OT  - adverse effects
OT  - brachytherapy
OT  - cervical cancer
OT  - chemotherapy
OT  - radiation therapy
COIS- The authors have declared that no competing interests exist.
EDAT- 2024/03/15 06:44
MHDA- 2024/03/15 06:45
PMCR- 2024/02/13
CRDT- 2024/03/15 04:03
PHST- 2024/02/13 00:00 [accepted]
PHST- 2024/03/15 06:45 [medline]
PHST- 2024/03/15 06:44 [pubmed]
PHST- 2024/03/15 04:03 [entrez]
PHST- 2024/02/13 00:00 [pmc-release]
AID - 10.7759/cureus.54106 [doi]
PST - epublish
SO  - Cureus. 2024 Feb 13;16(2):e54106. doi: 10.7759/cureus.54106. eCollection 2024 
      Feb.