PMID- 38487996
OWN - NLM
STAT- Publisher
LR  - 20240315
IS  - 1537-6613 (Electronic)
IS  - 0022-1899 (Linking)
DP  - 2024 Mar 15
TI  - A bivalent Adenovirus-Vectored Vaccine induces a robust humoral response, but 
      does not protect cynomolgus macaques against a lethal challenge with Sudan virus.
LID - jiae056 [pii]
LID - 10.1093/infdis/jiae056 [doi]
AB  - The most recent Sudan virus (SUDV) outbreak in Uganda was first detected in 
      September 2022 and resulted in 164 laboratory-confirmed cases and 77 deaths. 
      There are no approved vaccines against SUDV. Here, we investigated the protective 
      efficacy of ChAdOx1-biEBOV in cynomolgus macaques using a prime or a prime-boost 
      regimen. ChAdOx1-biEBOV is a replication-deficient simian adenovirus vector 
      encoding SUDV and Ebola virus (EBOV) glycoproteins (GPs). Intramuscular 
      vaccination induced SUDV and EBOV GP-specific IgG responses and neutralizing 
      antibodies. Upon challenge with SUDV, vaccinated animals showed signs of disease 
      like those observed in control animals, and no difference in survival outcomes 
      were measured among all three groups. Viral load in blood samples and in tissue 
      samples obtained after necropsy were not significantly different between groups. 
      Overall, this study highlights the importance of evaluating vaccines in multiple 
      animal models and demonstrates the importance of understanding protective 
      efficacy in both animal models and human hosts.
CI  - Published by Oxford University Press on behalf of Infectious Diseases Society of 
      America 2024.
FAU - van Tol, Sarah
AU  - van Tol S
AD  - Laboratory of Virology, National Institute of Allergy and Infectious Diseases, 
      National Institutes of Health, Hamilton, MT, USA.
FAU - Fletcher, Paige
AU  - Fletcher P
AD  - Laboratory of Virology, National Institute of Allergy and Infectious Diseases, 
      National Institutes of Health, Hamilton, MT, USA.
FAU - Feldmann, Friederike
AU  - Feldmann F
AD  - Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious 
      Diseases, National Institutes of Health, Hamilton, MT, USA.
FAU - Mukesh, Reshma K
AU  - Mukesh RK
AD  - Laboratory of Virology, National Institute of Allergy and Infectious Diseases, 
      National Institutes of Health, Hamilton, MT, USA.
FAU - Port, Julia R
AU  - Port JR
AD  - Laboratory of Virology, National Institute of Allergy and Infectious Diseases, 
      National Institutes of Health, Hamilton, MT, USA.
FAU - Gallogly, Shane
AU  - Gallogly S
AD  - Laboratory of Virology, National Institute of Allergy and Infectious Diseases, 
      National Institutes of Health, Hamilton, MT, USA.
FAU - Schulz, Jonathan E
AU  - Schulz JE
AD  - Laboratory of Virology, National Institute of Allergy and Infectious Diseases, 
      National Institutes of Health, Hamilton, MT, USA.
FAU - Rhoderick, Joseph F
AU  - Rhoderick JF
AD  - Laboratory of Virology, National Institute of Allergy and Infectious Diseases, 
      National Institutes of Health, Hamilton, MT, USA.
FAU - Makinson, Rebecca
AU  - Makinson R
AD  - Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, 
      UK.
FAU - Carmody, Aaron
AU  - Carmody A
AD  - Research Technologies Branch, National Institute of Allergy and Infectious 
      Diseases, National Institutes of Health, Hamilton, MT, USA.
FAU - Myers, Lara
AU  - Myers L
AD  - Research Technologies Branch, National Institute of Allergy and Infectious 
      Diseases, National Institutes of Health, Hamilton, MT, USA.
FAU - Lovaglio, Jamie
AU  - Lovaglio J
AD  - Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious 
      Diseases, National Institutes of Health, Hamilton, MT, USA.
FAU - Smith, Brian J
AU  - Smith BJ
AD  - Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious 
      Diseases, National Institutes of Health, Hamilton, MT, USA.
FAU - Okumura, Atsushi
AU  - Okumura A
AD  - Laboratory of Virology, National Institute of Allergy and Infectious Diseases, 
      National Institutes of Health, Hamilton, MT, USA.
FAU - Shaia, Carl
AU  - Shaia C
AD  - Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious 
      Diseases, National Institutes of Health, Hamilton, MT, USA.
FAU - Saturday, Greg
AU  - Saturday G
AD  - Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious 
      Diseases, National Institutes of Health, Hamilton, MT, USA.
FAU - Marzi, Andrea
AU  - Marzi A
AUID- ORCID: 0000-0003-0186-9587
AD  - Laboratory of Virology, National Institute of Allergy and Infectious Diseases, 
      National Institutes of Health, Hamilton, MT, USA.
FAU - Lambe, Teresa
AU  - Lambe T
AD  - Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, 
      UK.
FAU - Munster, Vincent J
AU  - Munster VJ
AD  - Laboratory of Virology, National Institute of Allergy and Infectious Diseases, 
      National Institutes of Health, Hamilton, MT, USA.
FAU - van Doremalen, Neeltje
AU  - van Doremalen N
AUID- ORCID: 0000-0003-4368-6359
AD  - Laboratory of Virology, National Institute of Allergy and Infectious Diseases, 
      National Institutes of Health, Hamilton, MT, USA.
LA  - eng
PT  - Journal Article
DEP - 20240315
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
SB  - IM
OTO - NOTNLM
OT  - Ebola virus
OT  - NHP
OT  - Sudan virus
OT  - adenovirus-vectored vaccine
OT  - animal model
OT  - filovirus
OT  - vaccine
EDAT- 2024/03/15 12:46
MHDA- 2024/03/15 12:46
CRDT- 2024/03/15 06:03
PHST- 2023/10/26 00:00 [received]
PHST- 2023/12/19 00:00 [revised]
PHST- 2024/01/30 00:00 [accepted]
PHST- 2024/03/15 12:46 [medline]
PHST- 2024/03/15 12:46 [pubmed]
PHST- 2024/03/15 06:03 [entrez]
AID - 7629702 [pii]
AID - 10.1093/infdis/jiae056 [doi]
PST - aheadofprint
SO  - J Infect Dis. 2024 Mar 15:jiae056. doi: 10.1093/infdis/jiae056.