PMID- 38488561
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240426
IS  - 1673-5374 (Print)
IS  - 1876-7958 (Electronic)
IS  - 1673-5374 (Linking)
VI  - 19
IP  - 10
DP  - 2024 Oct 1
TI  - 3'-Deoxyadenosin alleviates methamphetamine-induced aberrant synaptic plasticity 
      and seeking behavior by inhibiting the NLRP3 inflammasome.
PG  - 2270-2280
LID - 10.4103/1673-5374.392887 [doi]
AB  - JOURNAL/nrgr/04.03/01300535-202410000-00028/figure1/v/2024-02-06T055622Z/r/image-tiff 
      Methamphetamine addiction is a brain disorder characterized by persistent 
      drug-seeking behavior, which has been linked with aberrant synaptic plasticity. 
      An increasing body of evidence suggests that aberrant synaptic plasticity is 
      associated with the activation of the NOD-like receptor family pyrin domain 
      containing-3 (NLRP3) inflammasome. 3'-Deoxyadenosin, an active component of the 
      Chinese fungus Cordyceps militaris, has strong anti-inflammatory effects. 
      However, whether 3'-deoxyadenosin attenuates methamphetamine-induced aberrant 
      synaptic plasticity via an NLRP3-mediated inflammatory mechanism remains unclear. 
      We first observed that 3'-deoxyadenosin attenuated conditioned place preference 
      scores in methamphetamine-treated mice and decreased the expression of c-fos in 
      hippocampal neurons. Furthermore, we found that 3'-deoxyadenosin reduced the 
      aberrant potentiation of glutamatergic transmission and restored the 
      methamphetamine-induced impairment of synaptic plasticity. We also found that 
      3'-deoxyadenosin decreased the expression of NLRP3 and neuronal injury. 
      Importantly, a direct NLRP3 deficiency reduced methamphetamine-induced seeking 
      behavior, attenuated the impaired synaptic plasticity, and prevented neuronal 
      damage. Finally, NLRP3 activation reversed the effect of 3'-deoxyadenosin on 
      behavior and synaptic plasticity, suggesting that the anti-neuroinflammatory 
      mechanism of 3'-deoxyadenosin on aberrant synaptic plasticity reduces 
      methamphetamine-induced seeking behavior. Taken together, 3'-deoxyadenosin 
      alleviates methamphetamine-induced aberrant synaptic plasticity and seeking 
      behavior by inhibiting the NLRP3 inflammasome.
CI  - Copyright (c) 2024 Copyright: (c) 2024 Neural Regeneration Research.
FAU - Qi, Yize
AU  - Qi Y
AD  - Institute for Stem Cell and Neural Regeneration and Key Laboratory of 
      Cardiovascular & Cerebrovascular Medicine, School of Pharmacy, Nanjing Medical 
      University, Nanjing, Jiangsu Province, China.
FAU - Zhou, Yao
AU  - Zhou Y
AD  - Institute for Stem Cell and Neural Regeneration and Key Laboratory of 
      Cardiovascular & Cerebrovascular Medicine, School of Pharmacy, Nanjing Medical 
      University, Nanjing, Jiangsu Province, China.
FAU - Li, Jiyang
AU  - Li J
AD  - Institute for Stem Cell and Neural Regeneration and Key Laboratory of 
      Cardiovascular & Cerebrovascular Medicine, School of Pharmacy, Nanjing Medical 
      University, Nanjing, Jiangsu Province, China.
FAU - Zhu, Fangyuan
AU  - Zhu F
AD  - Institute for Stem Cell and Neural Regeneration and Key Laboratory of 
      Cardiovascular & Cerebrovascular Medicine, School of Pharmacy, Nanjing Medical 
      University, Nanjing, Jiangsu Province, China.
FAU - Guo, Gengni
AU  - Guo G
AD  - Institute for Stem Cell and Neural Regeneration and Key Laboratory of 
      Cardiovascular & Cerebrovascular Medicine, School of Pharmacy, Nanjing Medical 
      University, Nanjing, Jiangsu Province, China.
FAU - Wang, Can
AU  - Wang C
AD  - Institute for Stem Cell and Neural Regeneration and Key Laboratory of 
      Cardiovascular & Cerebrovascular Medicine, School of Pharmacy, Nanjing Medical 
      University, Nanjing, Jiangsu Province, China.
FAU - Yu, Man
AU  - Yu M
AD  - Institute for Stem Cell and Neural Regeneration and Key Laboratory of 
      Cardiovascular & Cerebrovascular Medicine, School of Pharmacy, Nanjing Medical 
      University, Nanjing, Jiangsu Province, China.
FAU - Wang, Yijie
AU  - Wang Y
AD  - Institute for Stem Cell and Neural Regeneration and Key Laboratory of 
      Cardiovascular & Cerebrovascular Medicine, School of Pharmacy, Nanjing Medical 
      University, Nanjing, Jiangsu Province, China.
FAU - Ma, Tengfei
AU  - Ma T
AUID- ORCID: 0000-0002-8916-7370
AD  - Institute for Stem Cell and Neural Regeneration and Key Laboratory of 
      Cardiovascular & Cerebrovascular Medicine, School of Pharmacy, Nanjing Medical 
      University, Nanjing, Jiangsu Province, China.
AD  - Department of Anesthesiology, The Second People's Hospital of Lianyungang, 
      Lianyungang, Jiangsu Province, China.
FAU - Feng, Shanwu
AU  - Feng S
AUID- ORCID: 0000-0002-5946-2811
AD  - Department of Anesthesiology, Women's Hospital of Nanjing Medical University, 
      Nanjing Maternity and Child Health Care Hospital, Nanjing, Jiangsu Province, 
      China.
FAU - Zhou, Li
AU  - Zhou L
AUID- ORCID: 0009-0000-5000-6679
AD  - Department of Anesthesiology, Women's Hospital of Nanjing Medical University, 
      Nanjing Maternity and Child Health Care Hospital, Nanjing, Jiangsu Province, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20240126
PL  - India
TA  - Neural Regen Res
JT  - Neural regeneration research
JID - 101316351
PMC - PMC11034599
COIS- Conflicts of interest: The authors declare that they have no competing interests.
EDAT- 2024/03/15 12:43
MHDA- 2024/03/15 12:44
PMCR- 2024/01/26
CRDT- 2024/03/15 10:25
PHST- 2023/04/17 00:00 [received]
PHST- 2023/12/08 00:00 [accepted]
PHST- 2024/03/15 12:44 [medline]
PHST- 2024/03/15 12:43 [pubmed]
PHST- 2024/03/15 10:25 [entrez]
PHST- 2024/01/26 00:00 [pmc-release]
AID - 01300535-202410000-00028 [pii]
AID - NRR-19-2270 [pii]
AID - 10.4103/1673-5374.392887 [doi]
PST - ppublish
SO  - Neural Regen Res. 2024 Oct 1;19(10):2270-2280. doi: 10.4103/1673-5374.392887. 
      Epub 2024 Jan 26.