PMID- 38488658
OWN - NLM
STAT- MEDLINE
DCOM- 20240318
LR  - 20240318
IS  - 1473-2300 (Electronic)
IS  - 0300-0605 (Print)
IS  - 0300-0605 (Linking)
VI  - 52
IP  - 3
DP  - 2024 Mar
TI  - Light chain deposition disease presenting with gastrointestinal disorder as 
      primary manifestation: report of two cases and literature review.
PG  - 3000605241233972
LID - 10.1177/03000605241233972 [doi]
LID - 03000605241233972
AB  - Light chain deposition disease (LCDD) is an under-recognized condition 
      characterized by deposition of abnormal monoclonal light chains in tissues, 
      leading to organ dysfunction. LCDD involving the gastrointestinal tract is very 
      uncommon, and its diagnosis is challenging. We herein report two cases of LCDD 
      that manifested as inflammatory bowel disease-like symptoms and protein-losing 
      gastroenteropathy. Both patients were women in their early 60s. Tissue biopsies 
      from the gastrointestinal mucosa demonstrated extracellular deposits, which were 
      negative by Congo red staining but positive for kappa-light chain by 
      immunohistochemistry. The recent literature on LCDD was reviewed. When patients 
      unexpectedly show extracellular deposits in gastrointestinal biopsy specimens, 
      evaluation of immunoglobulin chains is recommended for diagnosis of LCDD after 
      systemic amyloidosis has been excluded.
FAU - Wei, Chenxiang
AU  - Wei C
AD  - Division of Gastroenterology and Hepatology, The University of Hong Kong-Shenzhen 
      Hospital, Shenzhen, Guangdong, P.R. China. RINGGOLD: 444333
FAU - Wang, Min
AU  - Wang M
AD  - Division of Gastroenterology and Hepatology, The University of Hong Kong-Shenzhen 
      Hospital, Shenzhen, Guangdong, P.R. China. RINGGOLD: 444333
FAU - Li, Jiamin
AU  - Li J
AD  - Department of Pathology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, 
      Guangdong, P.R. China. RINGGOLD: 444333
FAU - Su, Jiajun
AU  - Su J
AD  - Department of Pathology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, 
      Guangdong, P.R. China. RINGGOLD: 444333
FAU - Huang, Jing
AU  - Huang J
AD  - Department of Hematology, The University of Hong Kong-Shenzhen Hospital, 
      Shenzhen, Guangdong, P.R. China. RINGGOLD: 444333
FAU - Tong, Sunwing
AU  - Tong S
AD  - Department of Pathology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, 
      Guangdong, P.R. China. RINGGOLD: 444333
FAU - Yang, Dongye
AU  - Yang D
AUID- ORCID: 0000-0003-3558-8871
AD  - Division of Gastroenterology and Hepatology, The University of Hong Kong-Shenzhen 
      Hospital, Shenzhen, Guangdong, P.R. China. RINGGOLD: 444333
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Int Med Res
JT  - The Journal of international medical research
JID - 0346411
RN  - 0 (Immunoglobulin Light Chains)
RN  - 0 (Immunoglobulin kappa-Chains)
SB  - IM
MH  - Humans
MH  - Female
MH  - Male
MH  - Immunoglobulin Light Chains
MH  - *Multiple Myeloma
MH  - Immunoglobulin kappa-Chains
MH  - *Amyloidosis/pathology
MH  - *Gastrointestinal Diseases/complications/diagnosis
PMC - PMC10943736
OTO - NOTNLM
OT  - Light chain deposition disease
OT  - bloody stool
OT  - case report
OT  - extracellular deposit
OT  - gastrointestinal biopsy
OT  - gastrointestinal tract
OT  - hypoalbuminemia
COIS- Declaration of conflicting interestsThe authors declare that there is no conflict 
      of interest.
EDAT- 2024/03/15 12:46
MHDA- 2024/03/18 06:44
PMCR- 2024/03/15
CRDT- 2024/03/15 10:54
PHST- 2024/03/18 06:44 [medline]
PHST- 2024/03/15 12:46 [pubmed]
PHST- 2024/03/15 10:54 [entrez]
PHST- 2024/03/15 00:00 [pmc-release]
AID - 10.1177_03000605241233972 [pii]
AID - 10.1177/03000605241233972 [doi]
PST - ppublish
SO  - J Int Med Res. 2024 Mar;52(3):3000605241233972. doi: 10.1177/03000605241233972.