PMID- 38492673
OWN - NLM
STAT- Publisher
LR  - 20240404
IS  - 1097-6825 (Electronic)
IS  - 0091-6749 (Linking)
DP  - 2024 Mar 15
TI  - Interactions between skin-resident dendritic and Langerhans cells and 
      pain-sensing neurons.
LID - S0091-6749(24)00270-7 [pii]
LID - 10.1016/j.jaci.2024.03.006 [doi]
AB  - Various immune cells in the skin contribute to its function as a first line of 
      defense against infection and disease, and the skin's dense innervation by 
      pain-sensing sensory neurons protects the host against injury or damage signals. 
      Dendritic cells (DCs) are a heterogeneous population of cells that link the 
      innate immune response to the adaptive response by capturing, processing, and 
      presenting antigens to promote T-cell differentiation and activation. DCs are 
      abundant across peripheral tissues, including the skin, where they are found in 
      the dermis and epidermis. Langerhans cells (LCs) are a DC subset located only in 
      the epidermis; both populations of cells can migrate to lymph nodes to contribute 
      to broad immune responses. Dermal DCs and LCs are found in close apposition with 
      sensory nerve fibers in the skin and express neurotransmitter receptors, allowing 
      them to communicate directly with the peripheral nervous system. Thus, 
      neuroimmune signaling between DCs and/or LCs and sensory neurons can modulate 
      physiologic and pathophysiologic pathways, including immune cell regulation, host 
      defense, allergic response, homeostasis, and wound repair. Here, we summarize the 
      latest discoveries on DC- and LC-neuron interaction with neurons while providing 
      an overview of gaps and areas not previously explored. Understanding the 
      interactions between these 2 defence systems may provide key insight into 
      developing therapeutic targets for treating diseases such as psoriasis, 
      neuropathic pain, and lupus.
CI  - Copyright (c) 2024 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Wilcox, Natalie C
AU  - Wilcox NC
AD  - Department of Biomedical and Molecular Sciences, Queen's University, Kingston, 
      Ontario, Canada.
FAU - Taheri, Golnar
AU  - Taheri G
AD  - Department of Biomedical and Molecular Sciences, Queen's University, Kingston, 
      Ontario, Canada.
FAU - Halievski, Katherine
AU  - Halievski K
AD  - Department of Anesthesiology and Perioperative Medicine, Queen's University, 
      Kingston, Ontario, Canada.
FAU - Talbot, Sebastien
AU  - Talbot S
AD  - Department of Biomedical and Molecular Sciences, Queen's University, Kingston, 
      Ontario, Canada.
FAU - Silva, Jaqueline R
AU  - Silva JR
AD  - Department of Biomedical and Molecular Sciences, Queen's University, Kingston, 
      Ontario, Canada; Department of Anesthesiology and Perioperative Medicine, Queen's 
      University, Kingston, Ontario, Canada; Centre for Neuroscience Studies, Queen's 
      University, Kingston, Ontario, Canada.
FAU - Ghasemlou, Nader
AU  - Ghasemlou N
AD  - Department of Biomedical and Molecular Sciences, Queen's University, Kingston, 
      Ontario, Canada; Department of Anesthesiology and Perioperative Medicine, Queen's 
      University, Kingston, Ontario, Canada; Centre for Neuroscience Studies, Queen's 
      University, Kingston, Ontario, Canada. Electronic address: 
      nader.ghasemlou@queensu.ca.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20240315
PL  - United States
TA  - J Allergy Clin Immunol
JT  - The Journal of allergy and clinical immunology
JID - 1275002
SB  - IM
OTO - NOTNLM
OT  - Atopic diseases
OT  - dermatitis
OT  - neuroinflammation
OT  - neuropeptides
OT  - nociceptor
OT  - peripheral nervous system
OT  - psoriasis
OT  - sensory neuron
OT  - skin
COIS- Disclosure statement Supported by grants from the Canadian Institutes of Health 
      Research (#PJT173288 and PJT148980 to N.G.), Natural Sciences and Engineering 
      Research Council of Canada (#RGPIN-05604 to N.G.), and Canada Foundation for 
      Innovation (#34890 to N.G.). Disclosure of potential conflict of interest: The 
      authors declare that they have no relevant conflicts of interest.
EDAT- 2024/03/17 00:42
MHDA- 2024/03/17 00:42
CRDT- 2024/03/16 20:27
PHST- 2023/12/22 00:00 [received]
PHST- 2024/02/13 00:00 [revised]
PHST- 2024/03/05 00:00 [accepted]
PHST- 2024/03/17 00:42 [pubmed]
PHST- 2024/03/17 00:42 [medline]
PHST- 2024/03/16 20:27 [entrez]
AID - S0091-6749(24)00270-7 [pii]
AID - 10.1016/j.jaci.2024.03.006 [doi]
PST - aheadofprint
SO  - J Allergy Clin Immunol. 2024 Mar 15:S0091-6749(24)00270-7. doi: 
      10.1016/j.jaci.2024.03.006.