PMID- 38495893 OWN - NLM STAT- MEDLINE DCOM- 20240319 LR - 20240403 IS - 1664-3224 (Electronic) IS - 1664-3224 (Linking) VI - 15 DP - 2024 TI - Associations of perchlorate, nitrate, and thiocyanate exposure with arthritis and inflammation indicators in young and middle-aged adults, NHANES 2005-2016. PG - 1318737 LID - 10.3389/fimmu.2024.1318737 [doi] LID - 1318737 AB - BACKGROUND: Perchlorates, nitrates, and thiocyanates are prevalent environmental chemicals. Their potential association with arthritis remains unexplored. This study aimed to investigate the link between perchlorate, nitrate, and thiocyanate exposure and arthritis, as well as the potential role of inflammation in this context. METHODS: Utilizing the National Health and Nutrition Examination Survey (NHANES) data spanning from 2005 to 2016, the study enrolled 6597 participants aged 20-59 (young and middle-aged), of which 1045 had arthritis. Employing multivariate logistic regression modeling, multiple linear regression models, restricted cubic spline analysis, Bayesian kernel machine regression (BKMR) modeling, and mediation analysis, we assessed these relationships. RESULTS: There was a significant positive association between elevated urinary thiocyanate levels and arthritis risk [1.19 (1.11, 1.28)]. This association held true across subgroups of osteoarthritis (OA) [1.24 (1.10, 1.40)] and rheumatoid arthritis (RA) [1.33 (1.15, 1.55)]. Thiocyanate levels displayed a dose-dependent relationship with arthritis risk, showing a linear trend (nonlinear P > 0.05). Conversely, perchlorate and nitrate did not exhibit associations with arthritis risk. BKMR outcomes highlighted a positive correlation between a mixture of perchlorate, nitrate, and thiocyanate and arthritis risk, with thiocyanate being the predominant predictors. Moreover, BKMR and generalized linear model analyses unveiled no significant synergistic effect of urinary perchlorate, nitrate, and thiocyanate on arthritis risk. Furthermore, thiocyanate exposure has been linked to elevated levels of inflammatory indicators (white blood cell, neutrophils, lymphocytes, and systemic immune-inflammatory index (SII)). CONCLUSION: Heightened thiocyanate exposure may be linked to elevated arthritis risk, either single or in combined effects. Additionally, thiocyanate exposure is associated with heightened inflammation levels. CI - Copyright (c) 2024 Zhao, Chen, Ni, Fang, Chen, Ma, Cai and Pan. FAU - Zhao, Hui AU - Zhao H AD - Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China. AD - The Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei, Anhui, China. FAU - Chen, Xuyang AU - Chen X AD - Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China. AD - The Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei, Anhui, China. FAU - Ni, Jianping AU - Ni J AD - Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China. AD - The Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei, Anhui, China. FAU - Fang, Lanlan AU - Fang L AD - Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China. AD - The Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei, Anhui, China. FAU - Chen, Yuting AU - Chen Y AD - Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China. AD - The Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei, Anhui, China. FAU - Ma, Yubo AU - Ma Y AD - Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China. AD - The Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei, Anhui, China. FAU - Cai, Guoqi AU - Cai G AD - Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China. AD - The Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei, Anhui, China. FAU - Pan, Faming AU - Pan F AD - Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China. AD - The Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei, Anhui, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240301 PL - Switzerland TA - Front Immunol JT - Frontiers in immunology JID - 101560960 RN - 0 (Nitrates) RN - O748SU14OM (thiocyanate) RN - 0 (Thiocyanates) RN - VLA4NZX2P4 (perchlorate) RN - 0 (Perchlorates) SB - IM MH - Adult MH - Middle Aged MH - Humans MH - *Nitrates/adverse effects/urine MH - Thiocyanates/urine MH - Perchlorates/adverse effects/urine MH - Nutrition Surveys MH - Bayes Theorem MH - Inflammation/epidemiology MH - *Arthritis/epidemiology PMC - PMC10940346 OTO - NOTNLM OT - BKMR OT - NHANES OT - arthritis OT - inflammation OT - thiocyanate COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/03/18 06:43 MHDA- 2024/03/19 06:43 PMCR- 2024/01/01 CRDT- 2024/03/18 04:29 PHST- 2023/10/11 00:00 [received] PHST- 2024/02/19 00:00 [accepted] PHST- 2024/03/19 06:43 [medline] PHST- 2024/03/18 06:43 [pubmed] PHST- 2024/03/18 04:29 [entrez] PHST- 2024/01/01 00:00 [pmc-release] AID - 10.3389/fimmu.2024.1318737 [doi] PST - epublish SO - Front Immunol. 2024 Mar 1;15:1318737. doi: 10.3389/fimmu.2024.1318737. eCollection 2024.