PMID- 38496230
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240319
IS  - 1300-0667 (Print)
IS  - 1309-4866 (Electronic)
IS  - 1300-0667 (Linking)
VI  - 61
IP  - 1
DP  - 2024
TI  - Vitamin D: An Overlooked Parameter in Studies of Depression Using Optic Coherence 
      Tomography.
PG  - 66-72
LID - 10.29399/npa.28369 [doi]
AB  - INTRODUCTION: The relationship between depression and inflammation and the 
      resulting vascular/neuronal damage have been demonstrated in recent studies. In 
      this study we aimed to investigate inflammation and the possible degeneration 
      that can be caused by depression and accompanying vitamin D deficiency using a 
      non-invasive imaging method of optical coherence tomography (OCT). METHODS: 
      Twenty-four healthy controls and 42 drug free major depressive patients matched 
      for age, sex and eye measurements were compared in terms of vitamin D, C Reactive 
      Protein (CRP) and OCT parameters. The Hamilton Depression Rating Scale (HAM-D), 
      The Clinical Global Impressions Scale (CGI) and Global Assessment of Functioning 
      Scale (GAF) were used to assess disease severity. RESULTS: CRP level and 
      choroidal thickness in the major depression group were significantly higher than 
      the healthy controls. Vitamin D level and the ganglion cell layer (GCL) volume 
      was significantly lower in the major depression group compared to healthy 
      controls. Positive correlation was found between HAM-D and CRP in major 
      depressive patients; a negative correlation was found between current attack 
      duration and GCL volume. CGI was positively correlated with CRP and HAM-D. GAS 
      was negatively correlated with CRP and HAM-D. CONCLUSION: It has been shown that 
      major depression might be an inflammatory disorder with possible degenerative 
      processes observed with OCT and CRP measurements. But longitudinal follow up 
      studies are needed to demonstrate a cause and effect relationship.
CI  - Copyright: (c) 2024 Turkish Neuropsychiatric Society.
FAU - Turhan, Nur Ozgedik
AU  - Turhan NO
AD  - Izzet Baysal Mental Health and Diseases Hospital, Department of Psychiatry, Bolu, 
      Turkey.
FAU - Arisoy, Ozden
AU  - Arisoy O
AD  - Bolu Abant Izzet Baysal Training and Research Hospital, Department of Psychiatry, 
      Bolu, Turkey.
FAU - Ulas, Fatih
AU  - Ulas F
AD  - Bolu Abant Izzet Baysal Training and Research Hospital, Department of 
      Ophthalmology, Bolu, Turkey.
FAU - Bugdayci, Guler
AU  - Bugdayci G
AD  - Halic University Faculty of Medicine, Department of Biochemistry, Istanbul, 
      Turkey.
FAU - Gulner, Melek Altintas
AU  - Gulner MA
AD  - Sinop Ataturk State Hospital, Department of Ophthalmology, Sinop, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20240224
PL  - Turkey
TA  - Noro Psikiyatr Ars
JT  - Noro psikiyatri arsivi
JID - 9426194
PMC - PMC10943944
OTO - NOTNLM
OT  - C reactive protein
OT  - major depression
OT  - optical coherence tomography
OT  - vitamin D
COIS- Conflict of Interest: The authors declared that there is no conflict of interest.
EDAT- 2024/03/18 06:43
MHDA- 2024/03/18 06:44
PMCR- 2024/02/24
CRDT- 2024/03/18 04:33
PHST- 2022/11/24 00:00 [received]
PHST- 2023/03/16 00:00 [accepted]
PHST- 2024/03/18 06:44 [medline]
PHST- 2024/03/18 06:43 [pubmed]
PHST- 2024/03/18 04:33 [entrez]
PHST- 2024/02/24 00:00 [pmc-release]
AID - archneuro-61-66 [pii]
AID - 10.29399/npa.28369 [doi]
PST - epublish
SO  - Noro Psikiyatr Ars. 2024 Feb 24;61(1):66-72. doi: 10.29399/npa.28369. eCollection 
      2024.