PMID- 38496302
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240319
IS  - 2051-3380 (Print)
IS  - 2051-3380 (Electronic)
IS  - 2051-3380 (Linking)
VI  - 12
IP  - 3
DP  - 2024 Mar
TI  - A novel therapy for intractable chronic cough.
PG  - e01323
LID - 10.1002/rcr2.1323 [doi]
LID - e01323
AB  - Two cases of intractable chronic cough improved significantly with humidified 
      high flow therapy (HHFT). A 59-year-old woman with Primary Sjogren's disease and 
      interstitial lung disease, was trialled on a Fisher and Paykel myAIRVO system. 
      She reported sustained benefits of uninterrupted sleep and increased 
      socialization with tapering use of HHFT. A 67-year-old woman with idiopathic 
      pulmonary fibrosis also benefited from the use of myAIRVO. She had relentless 
      cough with minimal movement, and nocturnal cough causing fragmented sleep. Her 
      cough subsided considerably with continuous HHFT, but recurred without. Both 
      patients reported significant reductions in the cough visual analogue scale. The 
      mechanisms by which HHFT improve intractable cough may include reducing airway 
      dryness, inhibition of neutrophil inflammation and mucus obstruction, and 
      splinting of the airways. HHFT significantly improved cough and health-related 
      quality of life in two patients with interstitial lung disease. Further research 
      is warranted to explore the role of domiciliary HHFT.
CI  - (c) 2024 The Authors. Respirology Case Reports published by John Wiley & Sons 
      Australia, Ltd on behalf of The Asian Pacific Society of Respirology.
FAU - Bricknell, Matthew
AU  - Bricknell M
AUID- ORCID: 0009-0006-2512-0705
AD  - Department of Respiratory and Sleep Medicine Austin Health Melbourne Victoria 
      Australia.
FAU - Zhao, Chris Zi-Fan
AU  - Zhao CZ
AUID- ORCID: 0000-0002-9223-6293
AD  - Department of Respiratory and Sleep Medicine Austin Health Melbourne Victoria 
      Australia.
FAU - Smallwood, Natasha
AU  - Smallwood N
AD  - Department of Respiratory and Sleep Medicine Alfred Hospital Melbourne Victoria 
      Australia.
AD  - Respiratory Research @ Alfred, Central Clinical School Monash University 
      Melbourne Victoria Australia.
FAU - Goh, Nicole
AU  - Goh N
AD  - Department of Respiratory and Sleep Medicine Austin Health Melbourne Victoria 
      Australia.
AD  - Institute for Breathing and Sleep Melbourne Victoria Australia.
LA  - eng
PT  - Case Reports
DEP - 20240315
PL  - United States
TA  - Respirol Case Rep
JT  - Respirology case reports
JID - 101631052
PMC - PMC10942843
OTO - NOTNLM
OT  - chronic cough
OT  - humidified high flow therapy
OT  - intractable cough
COIS- Nicole Goh is an Associate Editor of Respirology Case Reports and a co-author of 
      this article. She was excluded from all editorial decision-making related to the 
      acceptance of this article for publication.
EDAT- 2024/03/18 06:42
MHDA- 2024/03/18 06:43
PMCR- 2024/03/15
CRDT- 2024/03/18 04:35
PHST- 2024/02/08 00:00 [received]
PHST- 2024/03/05 00:00 [accepted]
PHST- 2024/03/18 06:43 [medline]
PHST- 2024/03/18 06:42 [pubmed]
PHST- 2024/03/18 04:35 [entrez]
PHST- 2024/03/15 00:00 [pmc-release]
AID - RCR21323 [pii]
AID - 10.1002/rcr2.1323 [doi]
PST - epublish
SO  - Respirol Case Rep. 2024 Mar 15;12(3):e01323. doi: 10.1002/rcr2.1323. eCollection 
      2024 Mar.