PMID- 38496329
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240319
IS  - 2772-4875 (Electronic)
IS  - 2772-4875 (Linking)
VI  - 21
DP  - 2024 Jun
TI  - Estimating maximum work rate during cardiopulmonary exercise testing from the 
      six-minute walk distance in patients with heart failure.
PG  - 200247
LID - 10.1016/j.ijcrp.2024.200247 [doi]
LID - 200247
AB  - BACKGROUND: Exercise is recommended for patients with chronic heart failure (CHF) 
      and its intensity is usually set as a percentage of the maximal work rate (MWR) 
      during cardiopulmonary exercise testing (CPX) or a symptom-limited incremental 
      test (SLIT). As these tests are not always available in cardiac rehabilitation 
      due to logistic/cost constraints, we aimed to develop a predictive model to 
      estimate MWR at CPX (estMWR@CPX) in CHF patients using anthropometric and 
      clinical measures and the 6-min walk test (6 MWT), the most widely used exercise 
      field test. METHODS: This is a multicentre cross-sectional retrospective study in 
      a cardiac rehabilitation setting. Six hundred patients with HF in New York Heart 
      Association (NYHA) functional class I-III underwent both CPX and 6 MWT and, 
      through multivariable linear regression analysis, we defined several predictive 
      models to define estMWR@CPX. RESULTS: The best model included 6 MWT, sex, age, 
      weight, NYHA class, left ventricular ejection fraction (LVEF), smoking status and 
      chronic obstructive pulmonary disease COPD (adjusted R(2) = 0.55; 95% LoA -39 to 
      33 W). When LVEF was excluded as a predictor, the resulting model performed only 
      slightly worse (adjusted R(2) = 0.54; 95% LoA -42 to 34 W). Only in 34% of cases 
      was the percentage difference between estMWR@CPX and real MWR@CPX <10% in 
      absolute value. EstMWR@CPX tended to overestimate low values and underestimate 
      high values of true MWR@CPX. CONCLUSIONS: Our results showed a lack of accuracy 
      in the predictive model evaluated; therefore, for an accurate prescription of 
      cycle-ergometer exercise training, it is necessary to assess MWR by CPX or SLIT.
CI  - (c) 2024 The Authors.
FAU - Piaggi, Giancarlo
AU  - Piaggi G
AD  - Istituti Clinici Scientifici Maugeri IRCCS, Respiratory and Cardiac 
      Rehabilitation of the Institute of Montescano, Pavia, Italy.
FAU - Paneroni, Mara
AU  - Paneroni M
AD  - Istituti Clinici Scientifici Maugeri IRCCS, Cardio-Respiratory Rehabilitation of 
      the Institute of Lumezzane, Brescia, Italy.
FAU - Maestri, Roberto
AU  - Maestri R
AD  - Istituti Clinici Scientifici Maugeri IRCCS, Department of Biomedical Engineering 
      of the Institute of Montescano, Pavia, Italy.
FAU - Salvioni, Elisabetta
AU  - Salvioni E
AD  - Centro Cardiologico Monzino IRCCS, Milan, Italy.
FAU - Corra, Ugo
AU  - Corra U
AD  - Istituti Clinici Scientifici Maugeri IRCCS, Department of Cardiac Rehabilitation 
      of the Institute of Veruno, Novara, Italy.
FAU - Caporotondi, Angelo
AU  - Caporotondi A
AD  - Istituti Clinici Scientifici Maugeri IRCCS, Cardiac Rehabilitation of the 
      Institute of Montescano, Pavia, Italy.
FAU - Scalvini, Simonetta
AU  - Scalvini S
AD  - Istituti Clinici Scientifici Maugeri IRCCS, Cardiac Rehabilitation of the 
      Institute of Lumezzane, Brescia, Italy.
FAU - Agostoni, Piergiuseppe
AU  - Agostoni P
AD  - Centro Cardiologico Monzino IRCCS, Milan, Italy.
AD  - University of Milan, Department of Clinical Sciences and Community Health, Milan, 
      Italy.
FAU - La Rovere, Maria Teresa
AU  - La Rovere MT
AD  - Istituti Clinici Scientifici Maugeri IRCCS, Cardiac Rehabilitation of the 
      Institute of Montescano, Pavia, Italy.
LA  - eng
PT  - Journal Article
DEP - 20240217
PL  - Netherlands
TA  - Int J Cardiol Cardiovasc Risk Prev
JT  - International journal of cardiology. Cardiovascular risk and prevention
JID - 9918282077306676
PMC - PMC10943044
OTO - NOTNLM
OT  - 6-Min walking test
OT  - Cardiopulmonary exercise testing
OT  - Chronic heart failure
COIS- All Authors declare no conflict of interest relevant to the research, analysis, 
      or interpretation presented in the manuscript.
EDAT- 2024/03/18 06:43
MHDA- 2024/03/18 06:44
PMCR- 2024/02/17
CRDT- 2024/03/18 04:35
PHST- 2024/01/19 00:00 [received]
PHST- 2024/02/16 00:00 [accepted]
PHST- 2024/03/18 06:44 [medline]
PHST- 2024/03/18 06:43 [pubmed]
PHST- 2024/03/18 04:35 [entrez]
PHST- 2024/02/17 00:00 [pmc-release]
AID - S2772-4875(24)00012-6 [pii]
AID - 200247 [pii]
AID - 10.1016/j.ijcrp.2024.200247 [doi]
PST - epublish
SO  - Int J Cardiol Cardiovasc Risk Prev. 2024 Feb 17;21:200247. doi: 
      10.1016/j.ijcrp.2024.200247. eCollection 2024 Jun.