PMID- 38497369
OWN - NLM
STAT- MEDLINE
DCOM- 20240429
LR  - 20240429
IS  - 2055-6764 (Electronic)
IS  - 2055-6756 (Linking)
VI  - 9
IP  - 5
DP  - 2024 Apr 29
TI  - Sub-100 nm carriers by template polymerization for drug delivery applications.
PG  - 693-707
LID - 10.1039/d3nh00491k [doi]
AB  - Size-controlled drug delivery systems (DDSs) have gained significant attention in 
      the field of pharmaceutical sciences due to their potential to enhance drug 
      efficacy, minimize side effects, and improve patient compliance. This review 
      provides a concise overview of the preparation method, advancements, and 
      applications of size-controlled drug delivery systems focusing on the sub-100 nm 
      size DDSs. The importance of tailoring the size for achieving therapeutic goals 
      is briefly mentioned. We highlight the concept of "template polymerization", a 
      well-established method in covalent polymerization that offers precise control 
      over molecular weight. We demonstrate the utility of this approach in crafting a 
      monolayer of a polymer around biomolecule templates such as DNA, RNA, and 
      protein, achieving the generation of DDSs with sizes ranging from several tens of 
      nanometers. A few representative examples of small-size DDSs that share a 
      conceptual similarity to "template polymerization" are also discussed. This 
      review concludes by briefly discussing the drug release behaviors and the future 
      prospects of "template polymerization" for the development of innovative 
      size-controlled drug delivery systems, which promise to optimize drug delivery 
      precision, efficacy, and safety.
FAU - Hashim, P K
AU  - Hashim PK
AUID- ORCID: 0000-0001-9944-7926
AD  - Research Institute for Electronic Science, Hokkaido University, Kita 20, Nishi 
      10, Kita-ku, Sapporo, Hokkaido 001-0020, Japan. hashim@es.hokudai.ac.jp.
AD  - Graduate School of Life Science, Hokkaido University, Kita 10, Nishi 8, Kita-ku, 
      Sapporo, Hokkaido 060-0810, Japan.
FAU - Abdrabou, Shimaa Said Mohamed Ali
AU  - Abdrabou SSMA
AUID- ORCID: 0000-0002-4359-7754
AD  - Department of Pediatrics, Faculty of Medicine and Graduate School of Medicine, 
      Hokkaido University, Sapporo, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20240429
PL  - England
TA  - Nanoscale Horiz
JT  - Nanoscale horizons
JID - 101712576
RN  - 0 (Drug Carriers)
RN  - 0 (Polymers)
SB  - IM
MH  - *Polymerization
MH  - Humans
MH  - Drug Delivery Systems/methods
MH  - Drug Carriers/chemistry
MH  - Particle Size
MH  - Polymers/chemistry
MH  - Nanoparticles/chemistry
EDAT- 2024/03/18 12:47
MHDA- 2024/04/29 13:57
CRDT- 2024/03/18 06:33
PHST- 2024/04/29 13:57 [medline]
PHST- 2024/03/18 12:47 [pubmed]
PHST- 2024/03/18 06:33 [entrez]
AID - 10.1039/d3nh00491k [doi]
PST - epublish
SO  - Nanoscale Horiz. 2024 Apr 29;9(5):693-707. doi: 10.1039/d3nh00491k.