PMID- 38498179
OWN - NLM
STAT- MEDLINE
DCOM- 20240325
LR  - 20240325
IS  - 2731-7099 (Electronic)
IS  - 2731-7080 (Print)
IS  - 2731-7080 (Linking)
VI  - 65
IP  - 4
DP  - 2024 Apr
TI  - [Primary sclerosing cholangitis-Diagnosis and treatment 2024].
PG  - 347-356
LID - 10.1007/s00108-024-01697-0 [doi]
AB  - The etiology of primary sclerosing cholangitis (PSC) remains unclear, which 
      explains in part the lack of a causal treatment. The differential diagnostic 
      distinction from the even rarer immunoglobulin 4 (IgG4)-associated cholangitis 
      (IAC) is becoming increasingly more successful. Advances in the understanding of 
      different clinical courses, improvements in noninvasive diagnostics through 
      modern magnetic resonance imaging (MRI) and the introduction of liver 
      elastography have led to the development of improved prognostic models. The 
      evidence for recommendations on medicinal (e.g., ursodeoxycholic acid) or 
      endoscopic treatment (e.g., balloon dilatation and/or stent insertion) for PSC is 
      still low. In contrast, the long-term results of liver transplantation in PSC 
      patients are constantly improving. Due to the lack of highly sensitive and 
      specific screening methods the early recognition of cholangiocellular carcinoma 
      (CCC) as the most important complication is rarely successful. The continuous 
      improvement of endoscopic retrograde cholangiopancreatography (ERCP) and direct 
      cholangioscopy in combination with molecular biological and fluorescence in situ 
      hybridization (FISH) analyses of bile duct tissue samples are promising for 
      refined diagnostics. Due to the significantly increased risk of colorectal 
      cancer, an annual colonoscopy is recommended in the presence of inflammatory 
      bowel disease. Improvement of the early diagnostics of PSC and successful testing 
      of new treatment strategies raise hope for a continuous improvement in the 
      medical support of these complex patients.
CI  - (c) 2024. The Author(s).
FAU - Trauner, Michael
AU  - Trauner M
AD  - Klinische Abteilung fur Gastroenterologie und Hepatologie, Universitatsklinik fur 
      Innere Medizin III, Medizinische Universitat Wien, Wahringer Gurtel 18-20, 1090, 
      Wien, Osterreich. michael.trauner@meduniwien.ac.at.
FAU - Halilbasic, Emina
AU  - Halilbasic E
AD  - Klinische Abteilung fur Gastroenterologie und Hepatologie, Universitatsklinik fur 
      Innere Medizin III, Medizinische Universitat Wien, Wahringer Gurtel 18-20, 1090, 
      Wien, Osterreich.
FAU - Tatscher, Elisabeth
AU  - Tatscher E
AD  - Klinische Abteilung fur Gastroenterologie und Hepatologie, Universitatsklinik fur 
      Innere Medizin, Medizinische Universitat Graz, Auenbruggerplatz 15, 8036, Graz, 
      Osterreich.
FAU - Fickert, Peter
AU  - Fickert P
AD  - Klinische Abteilung fur Gastroenterologie und Hepatologie, Universitatsklinik fur 
      Innere Medizin, Medizinische Universitat Graz, Auenbruggerplatz 15, 8036, Graz, 
      Osterreich. peter.fickert@medunigraz.at.
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Primar sklerosierende Cholangitis - Diagnose und Therapie 2024.
DEP - 20240318
PL  - Germany
TA  - Inn Med (Heidelb)
JT  - Innere Medizin (Heidelberg, Germany)
JID - 9918384885306676
SB  - IM
MH  - Humans
MH  - *Cholangitis, Sclerosing/diagnosis
MH  - In Situ Hybridization, Fluorescence
MH  - Liver/pathology
MH  - Bile Ducts, Intrahepatic/pathology
MH  - *Bile Duct Neoplasms/diagnosis
PMC - PMC10959807
OTO - NOTNLM
OT  - Cholangiocellular carcinoma
OT  - Cholestasis
OT  - Chronic inflammatory bowel disease
OT  - Endoscopic retrograde cholangiopancreatography
OT  - Ursodeoxycholic acid
EDAT- 2024/03/19 00:42
MHDA- 2024/03/25 06:42
PMCR- 2024/03/18
CRDT- 2024/03/18 12:14
PHST- 2024/03/05 00:00 [accepted]
PHST- 2024/03/25 06:42 [medline]
PHST- 2024/03/19 00:42 [pubmed]
PHST- 2024/03/18 12:14 [entrez]
PHST- 2024/03/18 00:00 [pmc-release]
AID - 10.1007/s00108-024-01697-0 [pii]
AID - 1697 [pii]
AID - 10.1007/s00108-024-01697-0 [doi]
PST - ppublish
SO  - Inn Med (Heidelb). 2024 Apr;65(4):347-356. doi: 10.1007/s00108-024-01697-0. Epub 
      2024 Mar 18.