PMID- 38498197
OWN - NLM
STAT- MEDLINE
DCOM- 20240401
LR  - 20240401
IS  - 1435-5604 (Electronic)
IS  - 0914-8779 (Linking)
VI  - 42
IP  - 2
DP  - 2024 Mar
TI  - Associations of pyrethroid exposure with bone mineral density and osteopenia in 
      adults.
PG  - 242-252
LID - 10.1007/s00774-024-01499-2 [doi]
AB  - INTRODUCTION: This study was to investigate the correlations between pyrethroid 
      exposure and bone mineral density (BMD) and osteopenia. MATERIALS AND METHODS: 
      This cross-sectional study included 1389 participants over 50 years of age drawn 
      from the 2007-2010 and 2013-2014 National Health and Nutrition Examination Survey 
      (NHANES). Three pyrethroid metabolites, 3-phenoxybenzoic acid (3-PBA), 
      trans-3-(2,2-dichlorovinyl)-2,2-dimethyl-cyclopropane-1-carboxylic acid 
      (trans-DCCA), and 4-fluoro-3-phenoxybenzoic acid (4-F-3PBA) were used as 
      indicators of pyrethroid exposure. Low BMD was defined as T-score < - 1.0, 
      including osteopenia. Weighted multivariable linear regression analysis or 
      logistic regression analysis was utilized to evaluate the correlation between 
      pyrethroid exposure and BMD and low BMD. Bayesian kernel machine regression 
      (BKMR) model was utilized to analyze the correlation between pyrethroids mixed 
      exposure and low BMD. RESULTS: There were 648 (48.41%) patients with low BMD. In 
      individual pyrethroid metabolite analysis, both tertile 2 and tertile 3 of 
      trans-DCCA were negatively related to total femur, femur neck, and total spine 
      BMD [coefficient (beta) = - 0.041 to - 0.028; all P < 0.05]. Both tertile 2 and 
      tertile 3 of 4-F-3PBA were negatively related to total femur BMD (P < 0.05). Only 
      tertile 2 [odds ratio (OR) = 1.63; 95% CI = 1.07, 2.48] and tertile 3 (OR = 1.65; 
      95% CI = 1.10, 2.50) of trans-DCCA was correlated with an increased risk of low 
      BMD. The BKMR analysis indicated that there was a positive tendency between mixed 
      pyrethroids exposure and low BMD. CONCLUSION: In conclusion, pyrethroids exposure 
      was negatively correlated with BMD levels, and the associations of pyrethroids 
      with BMD and low BMD varied by specific pyrethroids, pyrethroid concentrations, 
      and bone sites.
CI  - (c) 2024. The Japanese Society Bone and Mineral Research.
FAU - Shen, Zhubin
AU  - Shen Z
AD  - Department of Spine Surgery, China-Japan Union Hospital of Jilin University, No. 
      126 Xiantai Street, Changchun, 130033, China. shenzb21@mails.jlu.edu.cn.
FAU - Zhang, Fengyi
AU  - Zhang F
AD  - Department of Spine Surgery, China-Japan Union Hospital of Jilin University, No. 
      126 Xiantai Street, Changchun, 130033, China.
FAU - Guan, Xiaoqing
AU  - Guan X
AD  - Department of Spine Surgery, China-Japan Union Hospital of Jilin University, No. 
      126 Xiantai Street, Changchun, 130033, China.
FAU - Liu, Zhiming
AU  - Liu Z
AD  - Department of Spine Surgery, The Affiliated Hospital of Qingdao University, 
      Qingdao, 266000, China.
FAU - Zong, Yuan
AU  - Zong Y
AD  - Department of Spine Surgery, China-Japan Union Hospital of Jilin University, No. 
      126 Xiantai Street, Changchun, 130033, China.
FAU - Zhang, Ding
AU  - Zhang D
AD  - Department of Spine Surgery, China-Japan Union Hospital of Jilin University, No. 
      126 Xiantai Street, Changchun, 130033, China.
FAU - Wang, Rui
AU  - Wang R
AD  - Department of Toxicology, School of Public, Health of Jilin University, 
      Changchun, 130021, China.
FAU - Xue, Qian
AU  - Xue Q
AD  - Department of Toxicology, School of Public, Health of Jilin University, 
      Changchun, 130021, China.
FAU - Ma, Wenxuan
AU  - Ma W
AD  - Department of Toxicology, School of Public, Health of Jilin University, 
      Changchun, 130021, China.
FAU - Zhuge, Ruijian
AU  - Zhuge R
AD  - Department of Toxicology, School of Public, Health of Jilin University, 
      Changchun, 130021, China.
FAU - Guo, Li
AU  - Guo L
AD  - Department of Toxicology, School of Public, Health of Jilin University, 
      Changchun, 130021, China.
FAU - Yin, Fei
AU  - Yin F
AD  - Department of Spine Surgery, China-Japan Union Hospital of Jilin University, No. 
      126 Xiantai Street, Changchun, 130033, China. yinfei999@jlu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20240318
PL  - Japan
TA  - J Bone Miner Metab
JT  - Journal of bone and mineral metabolism
JID - 9436705
RN  - 0 (Pyrethrins)
RN  - 69DC2655VH (3-phenoxybenzoic acid)
RN  - 0 (Insecticides)
RN  - 2215-77-2 (4-carboxybiphenyl ether)
RN  - 0 (Benzoates)
RN  - 0 (Phenyl Ethers)
SB  - IM
MH  - Adult
MH  - Humans
MH  - Middle Aged
MH  - *Pyrethrins/adverse effects/analysis/metabolism
MH  - *Insecticides/adverse effects/analysis/metabolism
MH  - Nutrition Surveys
MH  - Cross-Sectional Studies
MH  - Bone Density
MH  - Bayes Theorem
MH  - Environmental Exposure/adverse effects
MH  - *Bone Diseases, Metabolic/chemically induced/epidemiology
MH  - *Benzoates
MH  - *Phenyl Ethers
OTO - NOTNLM
OT  - Bone mineral density
OT  - Endocrine disruptor chemicals
OT  - Osteopenia
OT  - Pyrethroids
EDAT- 2024/03/19 00:42
MHDA- 2024/04/01 06:43
CRDT- 2024/03/18 12:15
PHST- 2023/12/09 00:00 [received]
PHST- 2024/01/15 00:00 [accepted]
PHST- 2024/04/01 06:43 [medline]
PHST- 2024/03/19 00:42 [pubmed]
PHST- 2024/03/18 12:15 [entrez]
AID - 10.1007/s00774-024-01499-2 [pii]
AID - 10.1007/s00774-024-01499-2 [doi]
PST - ppublish
SO  - J Bone Miner Metab. 2024 Mar;42(2):242-252. doi: 10.1007/s00774-024-01499-2. Epub 
      2024 Mar 18.