PMID- 38498272
OWN - NLM
STAT- Publisher
LR  - 20240318
IS  - 1573-2584 (Electronic)
IS  - 0301-1623 (Linking)
DP  - 2024 Mar 18
TI  - Association of urinary calcium excretion with chronic kidney disease in patients 
      with type 2 diabetes.
LID - 10.1007/s11255-024-03978-x [doi]
AB  - PURPOSE: Herein, we investigated the correlation between urinary calcium 
      excretion (UCaE) and chronic kidney disease (CKD) in patients with type 2 
      diabetes mellitus (T2DM). METHODS: From August 2018 to January 2023, a total of 
      2031 T2DM patients providing 24-h urine samples were included in the final 
      analyses. Patients were separated into four cohorts, based on the UCaE quartiles. 
      We then analyzed renal functional indicators like estimated glomerular filtration 
      rate (eGFR) and urinary albumin excretion (UAE) among the four groups. Lastly, we 
      utilized multivariable logistic regression models to investigate the correlation 
      between UCaE and CKD. RESULTS: After adjusting for confounding factors, we 
      observed a decreasing trend in CKD prevalence (36.3%, 13.0%, 7.5%, and 6.6%, 
      respectively, P < 0.001) across the UCaE quartiles. Albuminuria (55.5% vs. 40.0%, 
      36.5%, 37.4%) and macroalbuminuria prevalence (20.0% vs. 9.3%, 5.2%, 5.7%) in the 
      lowest quartile were markedly elevated, compared to the remaining three quartiles 
      (P < 0.001). Meanwhile, the eGFR level (P < 0.001) showed a clearly increasing 
      trend across the UCaE quartiles, and patients with moderate-to-severe decreases 
      in eGFR levels (with cutoff limits at 30-59, 15-30, and < 15 mL/min/1.73m2) were 
      mostly found in the lowest quartile (P < 0.001). Logistic regression analysis 
      revealed that patients in the lowest quartile experienced an enhanced prevalence 
      of CKD, relative to those in the highest quartile (odds ratio: 5.90, 95% 
      confidence interval: 3.60-9.67, P < 0.001). CONCLUSION: Decreased UCaE was 
      independently associated with the CKD prevalence in T2DM patients.
CI  - (c) 2024. The Author(s), under exclusive licence to Springer Nature B.V.
FAU - Wang, Yanru
AU  - Wang Y
AD  - Department of Geriatrics, Shanghai Tenth People's Hospital, Tongji University 
      School of Medicine, 301 Yanchang Middle Road, Shanghai, 200072, China.
FAU - Chen, Yuxing
AU  - Chen Y
AD  - Department of Geriatrics, Shanghai Tenth People's Hospital, Tongji University 
      School of Medicine, 301 Yanchang Middle Road, Shanghai, 200072, China.
FAU - Yu, Yanping
AU  - Yu Y
AD  - Department of Geriatrics, Shanghai Tenth People's Hospital, Tongji University 
      School of Medicine, 301 Yanchang Middle Road, Shanghai, 200072, China.
FAU - Pan, Xin
AU  - Pan X
AD  - Department of Geriatrics, Shanghai Tenth People's Hospital, Tongji University 
      School of Medicine, 301 Yanchang Middle Road, Shanghai, 200072, China.
FAU - Fu, Guoxiang
AU  - Fu G
AUID- ORCID: 0000-0003-4506-1782
AD  - Department of Geriatrics, Shanghai Tenth People's Hospital, Tongji University 
      School of Medicine, 301 Yanchang Middle Road, Shanghai, 200072, China. 
      fuguoxiang818@163.com.
LA  - eng
PT  - Journal Article
DEP - 20240318
PL  - Netherlands
TA  - Int Urol Nephrol
JT  - International urology and nephrology
JID - 0262521
SB  - IM
OTO - NOTNLM
OT  - Chronic kidney disease
OT  - Type 2 diabetes
OT  - Urinary calcium excretion
EDAT- 2024/03/19 00:42
MHDA- 2024/03/19 00:42
CRDT- 2024/03/18 12:21
PHST- 2023/10/30 00:00 [received]
PHST- 2024/02/04 00:00 [accepted]
PHST- 2024/03/19 00:42 [medline]
PHST- 2024/03/19 00:42 [pubmed]
PHST- 2024/03/18 12:21 [entrez]
AID - 10.1007/s11255-024-03978-x [pii]
AID - 10.1007/s11255-024-03978-x [doi]
PST - aheadofprint
SO  - Int Urol Nephrol. 2024 Mar 18. doi: 10.1007/s11255-024-03978-x.