PMID- 38499229
OWN - NLM
STAT- MEDLINE
DCOM- 20240416
LR  - 20240416
IS  - 1873-1708 (Electronic)
IS  - 0890-6238 (Linking)
VI  - 125
DP  - 2024 Apr
TI  - Association between polycyclic aromatic hydrocarbons and infertility in U.S. 
      women: National Health and Nutrition Examination Survey 2013-2016.
PG  - 108577
LID - S0890-6238(24)00044-3 [pii]
LID - 10.1016/j.reprotox.2024.108577 [doi]
AB  - Although there is a body of research indicating the potential impact of 
      polycyclic aromatic hydrocarbons (PAHs) exposure on male infertility, the 
      understanding of how PAH might affect female infertility is still limited. This 
      study aimed to evaluate associations of PAHs, both individually and as a mixture, 
      with female infertility using multiple logistic regression, Bayesian kernel 
      machine regression (BKMR), and quantile g-computation (QGC) models based on data 
      from the National Health and Nutrition Examination Survey (NHANES) 2013-2016. The 
      study included 729 female participants. Multiple logistic regression results 
      indicated that there was a significant association between the third tertile of 
      2-hydroxy fluorene (2-OHFLU) and female infertility, and the OR was 2.84 (95% CI: 
      1.24-6.53, P value = 0.015) compared with the first tertile after adjusting for 
      the potential covariates. The BKMR model revealed a positive overall trend 
      between mixed PAH exposure and female infertility, particularly when the mixture 
      was at or above the 55th percentile, where 2-hydroxynaphthalene (2-OHNAP) and 
      1-hydroxypyrene (1-OHPYR) were the primary influences of the mixture. The 
      univariate exposure-response function indicated positive associations between 
      individual PAH exposure, specifically 2-OHNAP, 2-OHFLU, and 1-OHPYR, and female 
      infertility. The QGC model also indicated a positive trend between exposure to a 
      mixture of PAHs and female infertility, although it did not reach statistical 
      significance (OR = 1.33, 95%CI: 0.86-2.07), with 1-OHPYR having the greatest 
      positive effect on the outcome. This study suggested that exposure to PAHs may be 
      associated with female infertility and further research is needed to consolidate 
      and confirm these findings.
CI  - Copyright (c) 2024 Elsevier Inc. All rights reserved.
FAU - Wu, Xiaomei
AU  - Wu X
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No.601 Huangpu Ave West, Guangzhou, Guangdong 510632, China; 
      Guangdong Key Laboratory of Environmental Exposure and Health, Jinan 
      University, Guangzhou, Guangdong 510632, China.
FAU - Wang, Suixiang
AU  - Wang S
AD  - Guangzhou Center for Disease Control and Prevention, Guangzhou, China.
FAU - Lin, Xiaoxiao
AU  - Lin X
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No.601 Huangpu Ave West, Guangzhou, Guangdong 510632, China; 
      Guangdong Key Laboratory of Environmental Exposure and Health, Jinan 
      University, Guangzhou, Guangdong 510632, China.
FAU - Liang, Huanzhu
AU  - Liang H
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No.601 Huangpu Ave West, Guangzhou, Guangdong 510632, China; 
      Guangdong Key Laboratory of Environmental Exposure and Health, Jinan 
      University, Guangzhou, Guangdong 510632, China.
FAU - Wu, Yingying
AU  - Wu Y
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No.601 Huangpu Ave West, Guangzhou, Guangdong 510632, China; 
      Guangdong Key Laboratory of Environmental Exposure and Health, Jinan 
      University, Guangzhou, Guangdong 510632, China.
FAU - Tan, Yuxuan
AU  - Tan Y
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No.601 Huangpu Ave West, Guangzhou, Guangdong 510632, China; 
      Guangdong Key Laboratory of Environmental Exposure and Health, Jinan 
      University, Guangzhou, Guangdong 510632, China.
FAU - Zeng, Huixian
AU  - Zeng H
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No.601 Huangpu Ave West, Guangzhou, Guangdong 510632, China; 
      Guangdong Key Laboratory of Environmental Exposure and Health, Jinan 
      University, Guangzhou, Guangdong 510632, China.
FAU - Chen, Qian
AU  - Chen Q
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No.601 Huangpu Ave West, Guangzhou, Guangdong 510632, China; 
      Guangdong Key Laboratory of Environmental Exposure and Health, Jinan 
      University, Guangzhou, Guangdong 510632, China.
FAU - Wang, Jie
AU  - Wang J
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No.601 Huangpu Ave West, Guangzhou, Guangdong 510632, China; 
      Guangdong Key Laboratory of Environmental Exposure and Health, Jinan 
      University, Guangzhou, Guangdong 510632, China.
FAU - Huang, Feng
AU  - Huang F
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No.601 Huangpu Ave West, Guangzhou, Guangdong 510632, China; 
      Guangdong Key Laboratory of Environmental Exposure and Health, Jinan 
      University, Guangzhou, Guangdong 510632, China.
FAU - Guo, Ziang
AU  - Guo Z
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No.601 Huangpu Ave West, Guangzhou, Guangdong 510632, China; 
      Guangdong Key Laboratory of Environmental Exposure and Health, Jinan 
      University, Guangzhou, Guangdong 510632, China.
FAU - Xing, Puyi
AU  - Xing P
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No.601 Huangpu Ave West, Guangzhou, Guangdong 510632, China; 
      Guangdong Key Laboratory of Environmental Exposure and Health, Jinan 
      University, Guangzhou, Guangdong 510632, China.
FAU - Nie, Jiyu
AU  - Nie J
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No.601 Huangpu Ave West, Guangzhou, Guangdong 510632, China; 
      Guangdong Key Laboratory of Environmental Exposure and Health, Jinan 
      University, Guangzhou, Guangdong 510632, China.
FAU - Yao, Huojie
AU  - Yao H
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No.601 Huangpu Ave West, Guangzhou, Guangdong 510632, China; 
      Guangdong Key Laboratory of Environmental Exposure and Health, Jinan 
      University, Guangzhou, Guangdong 510632, China.
FAU - Fu, Yingyin
AU  - Fu Y
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No.601 Huangpu Ave West, Guangzhou, Guangdong 510632, China; 
      Guangdong Key Laboratory of Environmental Exposure and Health, Jinan 
      University, Guangzhou, Guangdong 510632, China.
FAU - Yang, Zhiyu
AU  - Yang Z
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No.601 Huangpu Ave West, Guangzhou, Guangdong 510632, China; 
      Guangdong Key Laboratory of Environmental Exposure and Health, Jinan 
      University, Guangzhou, Guangdong 510632, China.
FAU - Zeng, Zurui
AU  - Zeng Z
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No.601 Huangpu Ave West, Guangzhou, Guangdong 510632, China; 
      Guangdong Key Laboratory of Environmental Exposure and Health, Jinan 
      University, Guangzhou, Guangdong 510632, China.
FAU - Xu, Hongbiao
AU  - Xu H
AD  - Department of Thyroid and Breast Surgery, the First Affiliated Hospital of Sun 
      Yat-Sen University, Guangzhou, Guangdong 510080, China. Electronic address: 
      xuhongbiao123456@163.com.
FAU - Zhong, Xingming
AU  - Zhong X
AD  - Guangdong Provincial Reproductive Science Institute (Guangdong Provincial 
      Fertility Hospital), Guangzhou 510600, China. Electronic address: 
      xingmingzh@126.com.
FAU - Jing, Chunxia
AU  - Jing C
AD  - Department of Public Health and Preventive Medicine, School of Medicine, Jinan 
      University, No.601 Huangpu Ave West, Guangzhou, Guangdong 510632, China; 
      Guangdong Key Laboratory of Environmental Exposure and Health, Jinan 
      University, Guangzhou, Guangdong 510632, China. Electronic address: 
      jcxphd@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20240316
PL  - United States
TA  - Reprod Toxicol
JT  - Reproductive toxicology (Elmsford, N.Y.)
JID - 8803591
RN  - 0 (Polycyclic Aromatic Hydrocarbons)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Humans
MH  - Male
MH  - Female
MH  - *Polycyclic Aromatic Hydrocarbons
MH  - Nutrition Surveys
MH  - *Infertility, Female/epidemiology
MH  - Bayes Theorem
MH  - *Infertility, Male
MH  - Biomarkers
OTO - NOTNLM
OT  - Association
OT  - Bayesian kernel machine regression (BKMR)
OT  - Infertility
OT  - PAHs
OT  - Quantile g-computation (QGC)
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2024/03/19 00:42
MHDA- 2024/04/16 12:44
CRDT- 2024/03/18 20:26
PHST- 2023/09/25 00:00 [received]
PHST- 2024/03/05 00:00 [revised]
PHST- 2024/03/15 00:00 [accepted]
PHST- 2024/04/16 12:44 [medline]
PHST- 2024/03/19 00:42 [pubmed]
PHST- 2024/03/18 20:26 [entrez]
AID - S0890-6238(24)00044-3 [pii]
AID - 10.1016/j.reprotox.2024.108577 [doi]
PST - ppublish
SO  - Reprod Toxicol. 2024 Apr;125:108577. doi: 10.1016/j.reprotox.2024.108577. Epub 
      2024 Mar 16.