PMID- 38499456
OWN - NLM
STAT- Publisher
LR  - 20240318
IS  - 1879-0828 (Electronic)
IS  - 0953-6205 (Linking)
DP  - 2024 Mar 18
TI  - Visit-to-visit blood pressure variability is associated with intrinsic capacity 
      decline: Results from the MAPT Study.
LID - S0953-6205(24)00097-9 [pii]
LID - 10.1016/j.ejim.2024.03.001 [doi]
AB  - BACKGROUND: The effectiveness of the body physiological regulatory mechanisms 
      declines in late life, and increased Blood Pressure Variability (BPV) may 
      represent an alteration in cardiovascular homeostatic patterns. Intrinsic 
      Capacity (IC) has been proposed by the World Health Organization as a marker of 
      healthy aging, based on individual's functional abilities and intended at 
      preserving successful aging. We aimed to investigate the association of 
      visit-to-visit BPV with IC decline in a population of community-dwelling older 
      adults. METHODS: The study population consisted of 1407 community-dwelling 
      participants aged >/=70 years from the MAPT study evaluated during the 5-year 
      follow-up. Systolic BPV (SBPV) and diastolic BPV (DBPV) were determined through 
      six indicators. Cognition, psychology, locomotion and vitality constituted the 
      four IC domains assessed. Total IC Z-score resulted from the sum of the four 
      domains Z-scores divided by 4. The incidence of domain impairment over time was 
      also assessed. RESULTS: Higher SBPV was significantly associated with poorer IC 
      Z-scores in all linear mixed models [1-SD increase of CV%: beta(SE)=-0.010(0.001), p 
      < 0.01]. Similar results were observed for DBPV [1-SD increase of CV%: 
      beta(SE)=-0.003(0.001), p = 0.02]. Incident IC impairment was significantly higher 
      in participants with greater SBPV, [HR=1.16 (95 % CI, 1.01-1.33), p = 0.03], 
      while greater DBPV did not show a higher risk of incident IC impairment. 
      CONCLUSIONS: Greater BPV is associated with IC decline over time. Our findings 
      support BP instability as a presumable index of altered cardiovascular 
      homeostatic mechanism, suggesting that BPV might be a clinical marker of aging 
      and addressable risk factor for promoting healthy aging.
CI  - Copyright (c) 2024. Published by Elsevier B.V.
FAU - Bencivenga, Leonardo
AU  - Bencivenga L
AD  - Department of Translational Medical Sciences, University of Naples Federico II, 
      Napoli, Italy; Gerontopole de Toulouse, Institut du Vieillissement, CHU de 
      Toulouse, France. Electronic address: leonardo.bencivenga@unina.it.
FAU - Strumia, Mathilde
AU  - Strumia M
AD  - Gerontopole de Toulouse, Institut du Vieillissement, CHU de Toulouse, France; UMR 
      INSERM 1295, Universite Toulouse III, Toulouse, France; Department of Pharmacy, 
      Toulouse University, Toulouse, France.
FAU - Rolland, Yves
AU  - Rolland Y
AD  - Gerontopole de Toulouse, Institut du Vieillissement, CHU de Toulouse, France; UMR 
      INSERM 1295, Universite Toulouse III, Toulouse, France.
FAU - Guyonnet, Sophie
AU  - Guyonnet S
AD  - Gerontopole de Toulouse, Institut du Vieillissement, CHU de Toulouse, France; UMR 
      INSERM 1295, Universite Toulouse III, Toulouse, France.
FAU - Parini, Angelo
AU  - Parini A
AD  - Institut Des Maladies Metaboliques Et Cardiovasculaires (I2MC), Toulouse, France.
FAU - Cestac, Philippe
AU  - Cestac P
AD  - Department of Pharmacy, Toulouse University, Toulouse, France.
FAU - Andrieu, Sandrine
AU  - Andrieu S
AD  - Gerontopole de Toulouse, Institut du Vieillissement, CHU de Toulouse, France; UMR 
      INSERM 1295, Universite Toulouse III, Toulouse, France.
FAU - Souto Barreto, Philipe De
AU  - Souto Barreto P
AD  - Gerontopole de Toulouse, Institut du Vieillissement, CHU de Toulouse, France; UMR 
      INSERM 1295, Universite Toulouse III, Toulouse, France.
FAU - Rouch, Laure
AU  - Rouch L
AD  - Gerontopole de Toulouse, Institut du Vieillissement, CHU de Toulouse, France; UMR 
      INSERM 1295, Universite Toulouse III, Toulouse, France; Department of Pharmacy, 
      Toulouse University, Toulouse, France.
CN  - MAPT/DSA group
LA  - eng
PT  - Journal Article
DEP - 20240318
PL  - Netherlands
TA  - Eur J Intern Med
JT  - European journal of internal medicine
JID - 9003220
SB  - IM
OTO - NOTNLM
OT  - Blood pressure variability
OT  - Hypertension
OT  - Intrinsic capacity
OT  - Older adults
COIS- Declaration of Competing Interest None to declare.
EDAT- 2024/03/19 00:42
MHDA- 2024/03/19 00:42
CRDT- 2024/03/18 22:56
PHST- 2023/10/14 00:00 [received]
PHST- 2024/02/25 00:00 [revised]
PHST- 2024/03/04 00:00 [accepted]
PHST- 2024/03/19 00:42 [medline]
PHST- 2024/03/19 00:42 [pubmed]
PHST- 2024/03/18 22:56 [entrez]
AID - S0953-6205(24)00097-9 [pii]
AID - 10.1016/j.ejim.2024.03.001 [doi]
PST - aheadofprint
SO  - Eur J Intern Med. 2024 Mar 18:S0953-6205(24)00097-9. doi: 
      10.1016/j.ejim.2024.03.001.