PMID- 38499796 OWN - NLM STAT- MEDLINE DCOM- 20240320 LR - 20240321 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 14 IP - 1 DP - 2024 Mar 19 TI - Evaluation study of single-anastomosis duodenal-ileal bypass with sleeve gastrectomy in the treatment of Chinese obese patients based on efficacy and nutrition. PG - 6522 LID - 10.1038/s41598-024-57289-3 [doi] LID - 6522 AB - To evaluate the efficacy and nutrition of single-anastomosis duodenal-ileal bypass with sleeve gastrectomy (SADI-S) in Chinese obese patients in the first postoperative year. Clinical data of 66 obese patients who underwent SADI-S surgery at China-Japan Union Hospital of Jilin University from November 2018 to May 2022 were retrospectively collected. The weight, body mass index (BMI), percentage of excess weight loss (%EWL), and percentage of total weight loss (%TWL) were recorded at 3, 6, and 12 months after surgery. Moreover, metabolic disease remission and nutrient deficiencies were assessed at 1 year postoperatively. Overall, 66 patients (38 males and 28 females) were recruited, with a mean age of 35 (18-61) years and an average preoperative BMI of 42.94 kg/m(2). Before surgery, 38 patients had type 2 diabetes mellitus (T2DM), 46 patients had hyperuricemia (HUA), 45 patients had hypertension (HTN), 35 patients had hyperlipidemia, 12 patients had hypercholesterolemia, 12 patients had hyper-low-density lipoproteinemia, and 14 patients had gastroesophageal reflux disease symptoms (GERD). All patients had undergone a DaVinci robotic or laparoscopic SADI-S surgery, and none converted to laparotomy or died. Four patients developed postoperative complications and were cured and discharged after conservative treatment or surgical treatment. At 3, 6 and 12 months, the average %EWL was 62.07 +/- 26.56, 85.93 +/- 27.92, and 106.65 +/- 29.65%, %TWL was 22.67 +/- 4.94, 32.10 +/- 5.18, and 40.56 +/- 7.89%, respectively. Fasting blood glucose (FBG), glycated hemoglobin (HbA1c), uric acid (UA), triglycerides (TG), blood pressure (BP), and other indexes were significantly lower after one year post-surgery compared with the preoperative period (P < 0.05). The remission rates of T2DM, HUA, HTN, hypertriglyceridemia, hypercholesterolemia, and hyper-low-density lipoproteinemia 1 year after surgery were 100, 65.2, 62.2, 94.3, 100, and100%, respectively. One year after surgery, the remission rate of GERD was 71.4% (10/14), the rate of new occurrence of GERD was 12.1% (8/66), and the overall incidence rate was 18.2% (12/66). Except for vitamin B12(vit B12), the other nutrient indexes were significantly decreased after 1 year of surgery relative to levels before surgery (P < 0.05). The deficiency rates for vitamin A (vit A), vitamin E (vit E), zinc ion (Zn), and folic acid (FA) were higher (45.5, 25.8, 24.2, and 16.7%, respectively); however, there were no related clinical symptoms. SADI-S had significant effects on weight loss and metabolic disease remission. The main nutrient deficiencies after SADI-S were vit A, vit E, Zn, and FA deficiencies. The long-term efficacy and safety of SADI-S warrant further follow-up. CI - (c) 2024. The Author(s). FAU - Hu, Lifu AU - Hu L AD - Department of Bariatric and Metabolic Surgery, China-Japan Union Hospital, Jilin University, Changchun, 130033, China. FAU - Wang, Lun AU - Wang L AD - Department of Bariatric and Metabolic Surgery, China-Japan Union Hospital, Jilin University, Changchun, 130033, China. FAU - Li, Shixing AU - Li S AD - Department of Bariatric and Metabolic Surgery, China-Japan Union Hospital, Jilin University, Changchun, 130033, China. FAU - Liu, Yang AU - Liu Y AD - Department of Bariatric and Metabolic Surgery, China-Japan Union Hospital, Jilin University, Changchun, 130033, China. FAU - Zhang, Zheng AU - Zhang Z AD - Department of Bariatric and Metabolic Surgery, China-Japan Union Hospital, Jilin University, Changchun, 130033, China. FAU - Xiao, Minghao AU - Xiao M AD - Department of Bariatric and Metabolic Surgery, China-Japan Union Hospital, Jilin University, Changchun, 130033, China. FAU - Zhang, Zhenhua AU - Zhang Z AD - Department of Bariatric and Metabolic Surgery, China-Japan Union Hospital, Jilin University, Changchun, 130033, China. FAU - Wei, Zhiqiang AU - Wei Z AD - Department of Bariatric and Metabolic Surgery, China-Japan Union Hospital, Jilin University, Changchun, 130033, China. FAU - Cui, Liang AU - Cui L AD - Department of Bariatric and Metabolic Surgery, China-Japan Union Hospital, Jilin University, Changchun, 130033, China. FAU - Jiang, Tao AU - Jiang T AD - Department of Bariatric and Metabolic Surgery, China-Japan Union Hospital, Jilin University, Changchun, 130033, China. jiangtao99@jlu.edu.cn. LA - eng GR - 2020SCZ04/the special health research talents project of Jilin province/ PT - Journal Article DEP - 20240319 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Male MH - Female MH - Humans MH - Adult MH - *Obesity, Morbid/complications MH - *Diabetes Mellitus, Type 2/complications MH - Retrospective Studies MH - *Hypercholesterolemia/complications MH - Ileum/surgery MH - Obesity/complications MH - Anastomosis, Surgical/adverse effects MH - Gastrectomy/adverse effects MH - *Hypertension/complications MH - Weight Loss/physiology MH - *Gastroesophageal Reflux/complications MH - *Gastric Bypass/adverse effects MH - Treatment Outcome PMC - PMC10948890 OTO - NOTNLM OT - Bariatric surgery OT - Nutrients OT - Obesity OT - Single-anastomotic duodenal-ileal bypass with sleeve gastrectomy OT - Type 2 diabetes mellitus COIS- The authors declare no competing interests. EDAT- 2024/03/19 06:44 MHDA- 2024/03/20 06:45 PMCR- 2024/03/19 CRDT- 2024/03/19 00:32 PHST- 2023/12/06 00:00 [received] PHST- 2024/03/16 00:00 [accepted] PHST- 2024/03/20 06:45 [medline] PHST- 2024/03/19 06:44 [pubmed] PHST- 2024/03/19 00:32 [entrez] PHST- 2024/03/19 00:00 [pmc-release] AID - 10.1038/s41598-024-57289-3 [pii] AID - 57289 [pii] AID - 10.1038/s41598-024-57289-3 [doi] PST - epublish SO - Sci Rep. 2024 Mar 19;14(1):6522. doi: 10.1038/s41598-024-57289-3.