PMID- 38500566
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240320
IS  - 2471-2531 (Electronic)
IS  - 2471-2531 (Linking)
VI  - 9
IP  - 2
DP  - 2024 Apr
TI  - Virtually delivered Mindfulness-Oriented Recovery Enhancement (MORE) reduces 
      daily pain intensity in patients with lumbosacral radiculopathy: a randomized 
      controlled trial.
PG  - e1132
LID - 10.1097/PR9.0000000000001132 [doi]
LID - e1132
AB  - INTRODUCTION: Lumbosacral radiculopathy (LR), also known as sciatica, is a common 
      type of radiating neurologic pain involving burning, tingling, and numbness in 
      the lower extremities. It has an estimated lifetime prevalence as high as 43%. 
      OBJECTIVES: The objective of this randomized controlled trial was to evaluate the 
      impact of virtually delivered Mindfulness-Oriented Recovery Enhancement (MORE) on 
      patients with LR during the COVID-19 pandemic. METHODS: Potentially eligible 
      patients were identified using electronic health record queries and phone 
      screenings. Participants were then randomized to MORE or treatment-as-usual (TAU) 
      for 8 weeks, with pain intensity assessed daily. At baseline and follow-up 
      visits, participants completed questionnaires assessing the primary outcome, 
      disability, as well as quality of life, depression, mindful reinterpretation of 
      pain, and trait mindfulness. RESULTS: In our study, patients undergoing virtual 
      delivery of MORE had greater improvements in daily pain intensity (P = 0.002) but 
      not in disability (P = 0.09), depression (P = 0.26), or quality of life (P = 0.99 
      and P = 0.89, SF-12 physical and mental component scores, respectively), relative 
      to TAU patients. In addition, patients in MORE experienced significantly greater 
      increases in mindful reinterpretation of pain (P = 0.029) and trait mindfulness 
      (P = 0.035). CONCLUSION: Among patients with lumbar radiculopathy, MORE 
      significantly reduced daily pain intensity but did not decrease disability or 
      depression symptoms. Given the long duration of symptoms in our sample, we 
      hypothesize the discrepancy between changes in daily pain intensity and 
      disability is due to fear avoidance behaviors common in patients with chronic 
      pain. As the first trial of a mindfulness intervention in patients with LR, these 
      findings should inform future integrative approaches to LR treatment, 
      particularly when considering the increasing use of virtual interventions 
      throughout the COVID-19 pandemic.
CI  - Copyright (c) 2024 The Author(s). Published by Wolters Kluwer Health, Inc. on 
      behalf of The International Association for the Study of Pain.
FAU - Wexler, Ryan S
AU  - Wexler RS
AUID- ORCID: 0000-0003-0121-2323
AD  - Helfgott Research Institute, National University of Natural Medicine, Portland, 
      OR, USA.
AD  - Center for Research and Training, Department of Wellness and Preventive Medicine, 
      Cleveland Clinic, Cleveland, OH, USA.
FAU - Fox, Devon J
AU  - Fox DJ
AD  - Helfgott Research Institute, National University of Natural Medicine, Portland, 
      OR, USA.
FAU - ZuZero, Danielle
AU  - ZuZero D
AD  - Helfgott Research Institute, National University of Natural Medicine, Portland, 
      OR, USA.
FAU - Bollen, Melissa
AU  - Bollen M
AD  - Helfgott Research Institute, National University of Natural Medicine, Portland, 
      OR, USA.
FAU - Parikshak, Anand
AU  - Parikshak A
AD  - Helfgott Research Institute, National University of Natural Medicine, Portland, 
      OR, USA.
FAU - Edmond, Hannah
AU  - Edmond H
AD  - Helfgott Research Institute, National University of Natural Medicine, Portland, 
      OR, USA.
FAU - Lemau, Johnny
AU  - Lemau J
AD  - Helfgott Research Institute, National University of Natural Medicine, Portland, 
      OR, USA.
FAU - Montenegro, Diane
AU  - Montenegro D
AD  - Helfgott Research Institute, National University of Natural Medicine, Portland, 
      OR, USA.
FAU - Ramirez, Jillian
AU  - Ramirez J
AD  - Helfgott Research Institute, National University of Natural Medicine, Portland, 
      OR, USA.
FAU - Kwin, Sophia
AU  - Kwin S
AD  - Helfgott Research Institute, National University of Natural Medicine, Portland, 
      OR, USA.
FAU - Thompson, Austin R
AU  - Thompson AR
AD  - Department of Orthopaedics and Rehabilitation, Oregon Health & Science 
      University, Portland, OR, USA.
FAU - Carlson, Hans L
AU  - Carlson HL
AD  - Department of Orthopaedics and Rehabilitation, Oregon Health & Science 
      University, Portland, OR, USA.
FAU - Marshall, Lynn M
AU  - Marshall LM
AD  - Department of Orthopaedics and Rehabilitation, Oregon Health & Science 
      University, Portland, OR, USA.
FAU - Kern, Thomas
AU  - Kern T
AD  - Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science 
      University, Portland, OR, USA.
FAU - Mist, Scott D
AU  - Mist SD
AD  - Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science 
      University, Portland, OR, USA.
FAU - Bradley, Ryan
AU  - Bradley R
AD  - Helfgott Research Institute, National University of Natural Medicine, Portland, 
      OR, USA.
AD  - Herbert Wertheim School of Public Health and Human Longevity Sciences, University 
      of California, San Diego, La Jolla, CA, USA.
FAU - Hanes, Douglas A
AU  - Hanes DA
AD  - Helfgott Research Institute, National University of Natural Medicine, Portland, 
      OR, USA.
FAU - Zwickey, Heather
AU  - Zwickey H
AD  - Helfgott Research Institute, National University of Natural Medicine, Portland, 
      OR, USA.
FAU - Pickworth, Courtney K
AU  - Pickworth CK
AD  - Helfgott Research Institute, National University of Natural Medicine, Portland, 
      OR, USA.
LA  - eng
PT  - Journal Article
DEP - 20240314
PL  - United States
TA  - Pain Rep
JT  - Pain reports
JID - 101683899
PMC - PMC10948133
OTO - NOTNLM
OT  - Chronic low back pain
OT  - Integrative pain management
OT  - Lumbosacral radiculopathy
OT  - Mindfulness-Oriented Recovery Enhancement
OT  - Mindfulness-based interventions
COIS- The authors have no conflict of interest to declare.Sponsorships or competing 
      interests that may be relevant to content are disclosed at the end of this 
      article.
EDAT- 2024/03/19 06:43
MHDA- 2024/03/19 06:44
PMCR- 2024/03/14
CRDT- 2024/03/19 03:36
PHST- 2023/05/11 00:00 [received]
PHST- 2023/11/04 00:00 [revised]
PHST- 2023/11/23 00:00 [accepted]
PHST- 2024/03/19 06:44 [medline]
PHST- 2024/03/19 06:43 [pubmed]
PHST- 2024/03/19 03:36 [entrez]
PHST- 2024/03/14 00:00 [pmc-release]
AID - PAINREPORTS-D-23-0051 [pii]
AID - 10.1097/PR9.0000000000001132 [doi]
PST - epublish
SO  - Pain Rep. 2024 Mar 14;9(2):e1132. doi: 10.1097/PR9.0000000000001132. eCollection 
      2024 Apr.