PMID- 38500812
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240320
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 15
DP  - 2024
TI  - Increased functional connectivity between default mode network and visual network 
      potentially correlates with duration of residual dizziness in patients with 
      benign paroxysmal positional vertigo.
PG  - 1363869
LID - 10.3389/fneur.2024.1363869 [doi]
LID - 1363869
AB  - OBJECTIVE: To assess changes in static and dynamic functional network 
      connectivity (sFNC and dFNC) and explore their correlations with clinical 
      features in benign paroxysmal positional vertigo (BPPV) patients with residual 
      dizziness (RD) after successful canalith repositioning maneuvers (CRM) using 
      resting-state fMRI. METHODS: We studied resting-state fMRI data from 39 BPPV 
      patients with RD compared to 38 BPPV patients without RD after successful CRM. 
      Independent component analysis and methods of sliding window and k-means 
      clustering were adopted to investigate the changes in dFNC and sFNC between the 
      two groups. Additionally, temporal features and meta-states were compared between 
      the two groups. Furthermore, the associations between fMRI results and clinical 
      characteristics were analyzed using Pearson's partial correlation analysis. 
      RESULTS: Compared with BPPV patients without RD, patients with RD had longer 
      duration of BPPV and higher scores of dizziness handicap inventory (DHI) before 
      successful CRM. BPPV patients with RD displayed no obvious abnormal sFNC compared 
      to patients without RD. In the dFNC analysis, patients with RD showed increased 
      FNC between default mode network (DMN) and visual network (VN) in state 4, the 
      FNC between DMN and VN was positively correlated with the duration of RD. 
      Furthermore, we found increased mean dwell time (MDT) and fractional windows (FW) 
      in state 1 but decreased MDT and FW in state 3 in BPPV patients with RD. The FW 
      of state 1 was positively correlated with DHI score before CRM, the MDT and FW of 
      state 3 were negatively correlated with the duration of BPPV before CRM in 
      patients with RD. Additionally, compared with patients without RD, patients with 
      RD showed decreased number of states and state span. CONCLUSION: The occurrence 
      of RD might be associated with increased FNC between DMN and VN, and the 
      increased FNC between DMN and VN might potentially correlate with the duration of 
      RD symptoms. In addition, we found BPPV patients with RD showed altered global 
      meta-states and temporal features. These findings are helpful for us to better 
      understand the underlying neural mechanisms of RD and potentially contribute to 
      intervention development for BPPV patients with RD.
CI  - Copyright (c) 2024 Chen, Cai, Xiao, Wei, Liu, Lin, Liu, Liu and Rong.
FAU - Chen, Zhengwei
AU  - Chen Z
AD  - Department of Neurology, Second Affiliated Hospital of Xuzhou Medical University, 
      Xuzhou, Jiangsu, China.
FAU - Cai, Yaxian
AU  - Cai Y
AD  - Department of Neurology, General Hospital of the Yangtze River Shipping, Wuhan, 
      Hubei, China.
FAU - Xiao, Lijie
AU  - Xiao L
AD  - Department of Neurology, Second Affiliated Hospital of Xuzhou Medical University, 
      Xuzhou, Jiangsu, China.
FAU - Wei, Xiu-E
AU  - Wei XE
AD  - Department of Neurology, Second Affiliated Hospital of Xuzhou Medical University, 
      Xuzhou, Jiangsu, China.
FAU - Liu, Yueji
AU  - Liu Y
AD  - Department of Neurology, Second Affiliated Hospital of Xuzhou Medical University, 
      Xuzhou, Jiangsu, China.
FAU - Lin, Cunxin
AU  - Lin C
AD  - Department of Neurology, Second Affiliated Hospital of Xuzhou Medical University, 
      Xuzhou, Jiangsu, China.
AD  - Graduate School of Xuzhou Medical University, Xuzhou, Jiangsu, China.
FAU - Liu, Dan
AU  - Liu D
AD  - Department of Neurology, Second Affiliated Hospital of Xuzhou Medical University, 
      Xuzhou, Jiangsu, China.
AD  - Graduate School of Xuzhou Medical University, Xuzhou, Jiangsu, China.
FAU - Liu, Haiyan
AU  - Liu H
AD  - Department of Neurology, Second Affiliated Hospital of Xuzhou Medical University, 
      Xuzhou, Jiangsu, China.
FAU - Rong, Liangqun
AU  - Rong L
AD  - Department of Neurology, Second Affiliated Hospital of Xuzhou Medical University, 
      Xuzhou, Jiangsu, China.
LA  - eng
PT  - Journal Article
DEP - 20240304
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC10944895
OTO - NOTNLM
OT  - benign paroxysmal positional vertigo
OT  - dynamic functional network connectivity
OT  - independent component analysis
OT  - residual dizziness
OT  - resting-state fMRI
OT  - static functional network connectivity
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2024/03/19 06:43
MHDA- 2024/03/19 06:44
PMCR- 2024/03/04
CRDT- 2024/03/19 03:42
PHST- 2023/12/31 00:00 [received]
PHST- 2024/02/23 00:00 [accepted]
PHST- 2024/03/19 06:44 [medline]
PHST- 2024/03/19 06:43 [pubmed]
PHST- 2024/03/19 03:42 [entrez]
PHST- 2024/03/04 00:00 [pmc-release]
AID - 10.3389/fneur.2024.1363869 [doi]
PST - epublish
SO  - Front Neurol. 2024 Mar 4;15:1363869. doi: 10.3389/fneur.2024.1363869. eCollection 
      2024.