PMID- 38501089
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240320
IS  - 1664-0640 (Print)
IS  - 1664-0640 (Electronic)
IS  - 1664-0640 (Linking)
VI  - 15
DP  - 2024
TI  - Treating depression at home with transcranial direct current stimulation: a 
      feasibility study.
PG  - 1335243
LID - 10.3389/fpsyt.2024.1335243 [doi]
LID - 1335243
AB  - INTRODUCTION: Treating major depressive disorder (MDD) with transcranial direct 
      current stimulation (tDCS) devices at home has various logistic advantages 
      compared to tDCS treatment in the clinic. However, preliminary (controlled) 
      studies showed side effects such as skin lesions and difficulties in the 
      implementation of home-based tDCS. Thus, more data are needed regarding the 
      feasibility and possible disadvantages of home-based tDCS. METHODS: Ten 
      outpatients (23-69 years) with an acute depressive episode were included for this 
      one-arm feasibility study testing home-based tDCS. All patients self-administered 
      prefrontal tDCS (2 mA, 20 min, anodal left, cathodal right) at home on 30 
      consecutive working days supported by video consultations. Correct implementation 
      of the home-based treatment was analyzed with tDCS recordings. Feasibility was 
      examined by treatment compliance. For additional analyses of effectiveness, three 
      depression scores were used: Hamilton depression rating scale (HDRS-21), Major 
      Depression Inventory (MDI), and the subscale depression of the 
      Depression-Anxiety-Stress Scale (DASS). Furthermore, usability was measured with 
      the user experience questionnaire (UEQ). Tolerability was analyzed by the number 
      of reported adverse events (AEs). RESULTS: Eight patients did not stick to the 
      protocol. AEs were minimal. Four patients responded to the home treatment 
      according to the MDI. Usability was judged positive by the patients. CONCLUSIONS: 
      Regular video consultations or other safety concepts are recommended regardless 
      of the number of video sessions actually conducted. Home-based tDCS seems to be 
      safe and handy in our feasibility study, warranting further investigation.
CI  - Copyright (c) 2024 Dragon, Abdelnaim, Weber, Heuschert, Englert, Langguth, Hebel 
      and Schecklmann.
FAU - Dragon, Katharina
AU  - Dragon K
AD  - Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, 
      Germany.
FAU - Abdelnaim, Mohamed A
AU  - Abdelnaim MA
AD  - Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, 
      Germany.
FAU - Weber, Franziska C
AU  - Weber FC
AD  - Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, 
      Germany.
FAU - Heuschert, Markus
AU  - Heuschert M
AD  - University Medical Center, University of Regensburg, Regensburg, Germany.
FAU - Englert, Leon
AU  - Englert L
AD  - University Medical Center, University of Regensburg, Regensburg, Germany.
FAU - Langguth, Berthold
AU  - Langguth B
AD  - Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, 
      Germany.
FAU - Hebel, Tobias
AU  - Hebel T
AD  - Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, 
      Germany.
FAU - Schecklmann, Martin
AU  - Schecklmann M
AD  - Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, 
      Germany.
LA  - eng
PT  - Journal Article
DEP - 20240304
PL  - Switzerland
TA  - Front Psychiatry
JT  - Frontiers in psychiatry
JID - 101545006
PMC - PMC10944921
OTO - NOTNLM
OT  - feasibility
OT  - home treatment
OT  - non-invasive
OT  - tDCS
OT  - transcranial direct current stimulation
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest. The authors declare that this study received three 
      home-tDCS devices free of charge from Neuroconn Illmenau, Germany. The company 
      was not involved in the study design, collection, analysis, interpretation of the 
      data, the writing or editing of this article or the decision to submit it for 
      publication.
EDAT- 2024/03/19 06:44
MHDA- 2024/03/19 06:45
PMCR- 2024/03/04
CRDT- 2024/03/19 03:46
PHST- 2023/11/08 00:00 [received]
PHST- 2024/02/13 00:00 [accepted]
PHST- 2024/03/19 06:45 [medline]
PHST- 2024/03/19 06:44 [pubmed]
PHST- 2024/03/19 03:46 [entrez]
PHST- 2024/03/04 00:00 [pmc-release]
AID - 10.3389/fpsyt.2024.1335243 [doi]
PST - epublish
SO  - Front Psychiatry. 2024 Mar 4;15:1335243. doi: 10.3389/fpsyt.2024.1335243. 
      eCollection 2024.