PMID- 38501359
OWN - NLM
STAT- Publisher
LR  - 20240319
IS  - 1601-0825 (Electronic)
IS  - 1354-523X (Linking)
DP  - 2024 Mar 19
TI  - The effect and mechanism of liraglutide on the biological functions of BMSCs in 
      diabetic patients.
LID - 10.1111/odi.14931 [doi]
AB  - OBJECTIVES: To investigate the effect of liraglutide on osteogenesis in human 
      alveolar bone marrow mesenchymal stem cells (BMSCs) and the influence of 
      liraglutide on implant-bone integration in rats with T2DM. SUBJECTS AND METHODS: 
      Extracting BMSCs from the alveoli of diabetic patients treated with insulin. 
      BMSCs were treated with different concentrations of liraglutide. Osteogenesis and 
      the underlying mechanism were investigated via ALP detection, ALP staining, 
      Alizarin Red S staining, Western blotting, and RT-PCR. Liraglutide was given to 
      Wistar and GK rats after implantation, and new bone formation around the implants 
      was analyzed via micro-CT. Implant-bone integration in rats was investigated via 
      toluidine blue staining. RESULTS: Liraglutide enhanced osteogenesis in BMSCs via 
      the BMP2/Smad/Runx2 signaling pathway. The optimal concentration of liraglutide 
      that promoted osteogenesis was 10(-8)  mol/L. At concentrations higher than 
      10(-7)  mol/L, liraglutide had a negative effect on BMSCs. At a concentration of 
      10(-8)  mol/L liraglutide, BMSCs and diabetes mellitus-bone marrow stromal cells 
      (DM-BMSCs) showed optimal osteogenesis. Liraglutide promoted implant-bone 
      integration and new bone formation in Wistar and GK rats. CONCLUSIONS: 
      Liraglutide not only promotes osteogenesis of BMSCs in normoglycemic individuals 
      but also enhances osteogenesis of BMSCs in diabetic patients treated with insulin 
      and enhances osseointegration in rats.
CI  - (c) 2024 Wiley Periodicals LLC.
FAU - Wang, Yao
AU  - Wang Y
AD  - Department of Dental Implant Center, Beijing Stomatological Hospital, School of 
      Stomatology, Capital Medical University, Beijing, China.
FAU - Sun, Yujie
AU  - Sun Y
AD  - Department of Dental Implant Center, Beijing Stomatological Hospital, School of 
      Stomatology, Capital Medical University, Beijing, China.
FAU - Yang, Bo
AU  - Yang B
AD  - Department of Dental Implant Center, Beijing Stomatological Hospital, School of 
      Stomatology, Capital Medical University, Beijing, China.
FAU - Li, Jun
AU  - Li J
AUID- ORCID: 0000-0002-9301-6073
AD  - Department of Dental Implant Center, Beijing Stomatological Hospital, School of 
      Stomatology, Capital Medical University, Beijing, China.
AD  - Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School 
      of Stomatology, Capital Medical University, Beijing, China.
FAU - Liang, Chao
AU  - Liang C
AD  - Department of Dental Implant Center, Beijing Stomatological Hospital, School of 
      Stomatology, Capital Medical University, Beijing, China.
AD  - Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School 
      of Stomatology, Capital Medical University, Beijing, China.
LA  - eng
GR  - YSP202104/Young Scientist Program of Beijing Stomatological Hospital, Capital 
      Medical University/
GR  - QML20231503/Beijing Hospitals Authority Youth Programme/
PT  - Journal Article
DEP - 20240319
PL  - Denmark
TA  - Oral Dis
JT  - Oral diseases
JID - 9508565
OTO - NOTNLM
OT  - bone implant contact
OT  - bone marrow mesenchymal stem cells (BMSCs)
OT  - dental implant
OT  - liraglutide
OT  - osteogenesis
OT  - type 2 diabetes mellitus
EDAT- 2024/03/19 12:42
MHDA- 2024/03/19 12:42
CRDT- 2024/03/19 06:03
PHST- 2024/02/28 00:00 [revised]
PHST- 2023/08/04 00:00 [received]
PHST- 2024/03/05 00:00 [accepted]
PHST- 2024/03/19 12:42 [medline]
PHST- 2024/03/19 12:42 [pubmed]
PHST- 2024/03/19 06:03 [entrez]
AID - 10.1111/odi.14931 [doi]
PST - aheadofprint
SO  - Oral Dis. 2024 Mar 19. doi: 10.1111/odi.14931.