PMID- 38501621
OWN - NLM
STAT- MEDLINE
DCOM- 20240320
LR  - 20240320
IS  - 1512-0112 (Print)
IS  - 1512-0112 (Linking)
IP  - 346
DP  - 2024 Jan
TI  - THE ROLE OF GLUTAMIC ACID DECARBOXYLASES IN DIABETES MELLITUS.
PG  - 52-55
AB  - In the context of diabetes mellitus (DM), anti-glutamic acid decarboxylase 
      (antiGAD) antibodies are associated with a specific form of the disease called 
      type 1 diabetes. The study aims to evaluate the serum cortisol and serotonin 
      levels in patients with type 2 DM disease. A total of 90 Iraqi participants (30 
      with type 1 diabetes mellitus, 30 with type 2 diabetes mellitus and 30 healthy 
      subjects as a control group) were enrolled in the study. Blood samples were 
      collected, serum separated, and frozen for future analysis. The level of 
      Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) was measured for 
      each person who participated in this study (whether DM diseases or control 
      individuals) and AntiGAD (anti-glutamic acid decarboxylase). The study examined 
      the descriptive statistics of HOMA-IR and AntiGAD levels in individuals with 
      different types of diabetes. The results showed that individuals with type 1 
      diabetes mellitus (T1DM) had a significantly lower HOMA-IR compared to the 
      control group, while individuals with type 2 diabetes mellitus (T2DM) had a 
      significantly higher HOMA-IR. The study also found that both T1DM and T2DM groups 
      had significantly elevated levels of AntiGAD compared to the control group. These 
      findings suggest that insulin resistance is reduced in T1DM individuals but 
      increased in T2DM individuals, and the presence of diabetes is associated with 
      increased levels of AntiGAD. In summary, the results of this study demonstrate 
      significant differences in both HOMA-IR and AntiGAD levels between individuals 
      with diabetes (T1DM and T2DM) and the control group. These findings contribute to 
      our understanding of the pathophysiology of diabetes and highlight the importance 
      of these biomarkers in the diagnosis and management of the disease. Further 
      research is needed to explore the underlying mechanisms behind these observations 
      and to determine their clinical implications.
FAU - Azeez, B
AU  - Azeez B
AD  - 1Baghdad Health Department, Al-Karkh, Iraq.
FAU - Saadoon, I
AU  - Saadoon I
AD  - 2College of Medicine, Tikrit University, Iraq.
FAU - Hussein, A
AU  - Hussein A
AD  - 2College of Medicine, Tikrit University, Iraq.
LA  - eng
PT  - Journal Article
PL  - Georgia (Republic)
TA  - Georgian Med News
JT  - Georgian medical news
JID - 101218222
RN  - EC 4.1.1.15 (Glutamate Decarboxylase)
RN  - 0 (Antibodies)
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2
MH  - *Diabetes Mellitus, Type 1/complications
MH  - *Insulin Resistance
MH  - Glutamate Decarboxylase
MH  - Antibodies
MH  - Blood Glucose/analysis
MH  - Insulin
EDAT- 2024/03/19 12:42
MHDA- 2024/03/20 06:45
CRDT- 2024/03/19 07:53
PHST- 2024/03/20 06:45 [medline]
PHST- 2024/03/19 12:42 [pubmed]
PHST- 2024/03/19 07:53 [entrez]
PST - ppublish
SO  - Georgian Med News. 2024 Jan;(346):52-55.