PMID- 38502938
OWN - NLM
STAT- Publisher
LR  - 20240319
IS  - 2444-054X (Electronic)
IS  - 0009-7411 (Linking)
DP  - 2024 Mar 19
TI  - Beneficial effects of IVIG treatment on experimental-induced osteoporosis.
LID - 10.24875/CIRU.23000219 [doi]
AB  - OBJECTIVE: Estrogen (E2) plays a significant role in postmenopausal osteoporosis, 
      and its deficiency is related to chronic low-grade inflammation. Intravenous 
      immunoglobulin (IVIG) is composed of immunoglobulins derived from the plasma of 
      healthy donors. Numerous anti-inflammatory pathways are responsible for IVIG's 
      anti-inflammatory action The aim of this study is to investigate the effects of 
      IVIG on experimental-induced osteoporosis. MATERIALS AND METHODS: Forty adult 
      female Wistar rats were included in the study. Thirty rats underwent bilateral 
      dorsal ovariectomy. Rats were grouped as Group 1 (n = 10, ovariectomy and 
      saline); Group 2 (n = 10, ovariectomy and E2); Group 3 (n = 10, ovariectomy and 
      IVIG), and Control group (n = 10, no oophorectomy). Histopathological examination 
      of bone tissue, and biochemical analysis for beta-catenin, plasma Tumor Necrosis 
      Factor-alpha, IL-6, receptor activator of nuclear-kappaB ligand (RANKL), and 
      osteoprotegerin (OPG) levels were made. RESULTS: The IVIG group had increased 
      trabecular number, area, and thickness with increased bone mineral density as 
      well as decreased trabecular separation compared with the saline group. IVIG 
      group had lower serum RANKL and higher serum OPG levels when compared with the 
      saline group. The bone marrow beta-catenin level was significantly higher in the 
      control and ovariectomy + IVIG groups. CONCLUSION: IVIG has beneficial effects on 
      experimentally induced osteoporosis with a possible action on inflammation and 
      RANKL-beta-catenin pathway.
FAU - Ozdemir, Savas
AU  - Ozdemir S
AD  - Department of Gynecology and Obstetrics, Istanbul Prof. Dr. Cemil Tascioglu City 
      Hospital, Istanbul, Turkey.
FAU - Erbas, Oytun
AU  - Erbas O
AD  - Department of Department of Physiology, Demiroglu Bilim University, Istanbul, 
      Turkey.
LA  - eng
PT  - Journal Article
DEP - 20240319
PL  - Mexico
TA  - Cir Cir
JT  - Cirugia y cirujanos
JID - 0372736
SB  - IM
OTO - NOTNLM
OT  - beta-catenin
OT  - IVIG
OT  - RANKL
OT  - Osteoporosis
EDAT- 2024/03/19 18:42
MHDA- 2024/03/19 18:42
CRDT- 2024/03/19 17:06
PHST- 2024/03/19 18:42 [medline]
PHST- 2024/03/19 18:42 [pubmed]
PHST- 2024/03/19 17:06 [entrez]
AID - 10.24875/CIRU.23000219 [doi]
PST - aheadofprint
SO  - Cir Cir. 2024 Mar 19. doi: 10.24875/CIRU.23000219.