PMID- 38503006
OWN - NLM
STAT- MEDLINE
DCOM- 20240415
LR  - 20240415
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 335
DP  - 2024 May
TI  - Development, validation and clinical utility of short-term adverse-effects of 
      electroconvulsive therapy (SAVE) checklist.
PG  - 115839
LID - S0165-1781(24)00124-0 [pii]
LID - 10.1016/j.psychres.2024.115839 [doi]
AB  - Electroconvulsive therapy (ECT) is one of the most effective treatments in 
      psychiatry. However, it has many cognitive and non-cognitive adverse effects 
      (AEs). There are lacunae in the literature on systematic assessment of 
      non-cognitive AEs. There is a need for a standard, comprehensive and specific 
      clinical tool to evaluate this. Hence, a checklist of short-term AEs of ECT 
      (SAVE) with a 2-phase assessment was developed. Content validation was done using 
      15 experts' ratings and predefined content validity ratio and index (CVR and CVI) 
      in a two-stage modified Delphi method. The checklist had a good CVR and CVI with 
      a final tool of 39 items. The tool was sensitive and identified the non-cognitive 
      AEs after ECT. Cardiovascular and musculoskeletal systems displayed the highest 
      incidence. Many participants exhibited delayed recovery in orientation, gait, and 
      stance, highlighting a necessity for meticulous monitoring. SAVE is the first 
      standardised tool to assess short-term ECT-related AEs systematically. This 
      checklist likely identifies clinically significant incidences of adverse effects. 
      Its regular use may enhance the safety of ECT and patient comfort by supporting 
      early identification and intervention for AEs. However, given the transient 
      nature of AEs, further studies are needed to determine their predictive validity 
      for long-term consequences.
CI  - Copyright (c) 2024 Elsevier B.V. All rights reserved.
FAU - Uppinkudru, Chithra
AU  - Uppinkudru C
AD  - Department of Psychiatry, National Institute of Mental Health and Neuro Sciences 
      (NIMHANS), Bengaluru, Karnataka India.
FAU - Pathak, Harsh
AU  - Pathak H
AD  - Department of Psychiatry, National Institute of Mental Health and Neuro Sciences 
      (NIMHANS), Bengaluru, Karnataka India.
FAU - Kumar K, Raj
AU  - Kumar K R
AD  - Department of Psychiatry, National Institute of Mental Health and Neuro Sciences 
      (NIMHANS), Bengaluru, Karnataka India.
FAU - S, Bridgit
AU  - S B
AD  - Department of Psychiatry, National Institute of Mental Health and Neuro Sciences 
      (NIMHANS), Bengaluru, Karnataka India.
FAU - Bagali, Kiran
AU  - Bagali K
AD  - Department of Psychiatry, National Institute of Mental Health and Neuro Sciences 
      (NIMHANS), Bengaluru, Karnataka India.
FAU - Pantoji, Makarand
AU  - Pantoji M
AD  - Department of Psychiatry, National Institute of Mental Health and Neuro Sciences 
      (NIMHANS), Bengaluru, Karnataka India.
FAU - Ezhumalai, Nathiya
AU  - Ezhumalai N
AD  - Department of Psychiatry, National Institute of Mental Health and Neuro Sciences 
      (NIMHANS), Bengaluru, Karnataka India.
FAU - Parlikar, Rujuta
AU  - Parlikar R
AD  - Department of Psychiatry, National Institute of Mental Health and Neuro Sciences 
      (NIMHANS), Bengaluru, Karnataka India.
FAU - Shah, Vyoma
AU  - Shah V
AD  - Department of Psychiatry, National Institute of Mental Health and Neuro Sciences 
      (NIMHANS), Bengaluru, Karnataka India.
FAU - Balachander, Srinivas
AU  - Balachander S
AD  - Department of Psychiatry, National Institute of Mental Health and Neuro Sciences 
      (NIMHANS), Bengaluru, Karnataka India.
FAU - Sreeraj, Vanteemar S
AU  - Sreeraj VS
AD  - Department of Psychiatry, National Institute of Mental Health and Neuro Sciences 
      (NIMHANS), Bengaluru, Karnataka India. Electronic address: vs8sreeraj@yahoo.com.
FAU - Mehta, Urvakhsh Meherwan
AU  - Mehta UM
AD  - Department of Psychiatry, National Institute of Mental Health and Neuro Sciences 
      (NIMHANS), Bengaluru, Karnataka India.
FAU - Sinha, Preeti
AU  - Sinha P
AD  - Department of Psychiatry, National Institute of Mental Health and Neuro Sciences 
      (NIMHANS), Bengaluru, Karnataka India.
FAU - Arumugham, Shyam Sundar
AU  - Arumugham SS
AD  - Department of Psychiatry, National Institute of Mental Health and Neuro Sciences 
      (NIMHANS), Bengaluru, Karnataka India.
FAU - Venkatasubramanian, Ganesan
AU  - Venkatasubramanian G
AD  - Department of Psychiatry, National Institute of Mental Health and Neuro Sciences 
      (NIMHANS), Bengaluru, Karnataka India.
FAU - Thirthalli, Jagadisha
AU  - Thirthalli J
AD  - Department of Psychiatry, National Institute of Mental Health and Neuro Sciences 
      (NIMHANS), Bengaluru, Karnataka India.
LA  - eng
PT  - Journal Article
DEP - 20240307
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
SB  - IM
MH  - Humans
MH  - *Electroconvulsive Therapy/adverse effects/methods
MH  - Checklist
MH  - *Drug-Related Side Effects and Adverse Reactions
MH  - Treatment Outcome
MH  - Forecasting
OTO - NOTNLM
OT  - Common side effects
OT  - Gait
OT  - Orientation
OT  - Psychiatric disorders
OT  - Recovery
OT  - Stance
COIS- Declaration of competing interest Authors have no conflict of interest to 
      declare.
EDAT- 2024/03/20 00:42
MHDA- 2024/04/15 06:44
CRDT- 2024/03/19 19:02
PHST- 2024/01/24 00:00 [received]
PHST- 2024/02/27 00:00 [revised]
PHST- 2024/03/03 00:00 [accepted]
PHST- 2024/04/15 06:44 [medline]
PHST- 2024/03/20 00:42 [pubmed]
PHST- 2024/03/19 19:02 [entrez]
AID - S0165-1781(24)00124-0 [pii]
AID - 10.1016/j.psychres.2024.115839 [doi]
PST - ppublish
SO  - Psychiatry Res. 2024 May;335:115839. doi: 10.1016/j.psychres.2024.115839. Epub 
      2024 Mar 7.