PMID- 38503080 OWN - NLM STAT- MEDLINE DCOM- 20240401 LR - 20240404 IS - 1532-2238 (Electronic) IS - 1096-6374 (Linking) VI - 75 DP - 2024 Apr TI - Duration-specific association between plasma IGFBP7 levels and diabetic complications in patients with type 2 diabetes mellitus. PG - 101574 LID - S1096-6374(24)00004-2 [pii] LID - 10.1016/j.ghir.2024.101574 [doi] AB - OBJECTIVE: Insulin-like growth factor binding protein 7 (IGFBP7) has a strong affinity to insulin. This study aimed to evaluate the relationship between IGFBP7 and complications among type 2 diabetes mellitus (T2DM) patients. DESIGN: A total of 1449 T2DM patients were selected from a cross-sectional study for disease management registered in the National Basic Public Health Service in Changshu, China, and further tested for their plasma IGFBP7 levels. Logistic regressions and Spearman's rank correlation analyses were used to explore the associations of IGFBP7 with diabetic complications and clinical characteristics, respectively. RESULTS: Among the 1449 included T2DM patients, 403 (27.81%) had complications. In patients with shorter duration (less than five years), the base 10 logarithms of IGFBP7 concentration were associated with T2DM complications, with an adjusted odds ratio (OR) of 2.41 [95% confidence interval (95%CI) = 1.06-5.48]; while in patients with longer duration (more than five years), plasma IGFBP7 levels were not associated with T2DM complications. Furthermore, in T2DM patients with shorter duration, those with two or more types of complications were more likely to have higher levels of IGFBP7. CONCLUSION: IGFBP7 is positively associated with the risk of complication in T2DM patients with shorter duration. CI - Copyright (c) 2024. Published by Elsevier Ltd. FAU - Zhu, Xiaoyan AU - Zhu X AD - School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Suzhou Center for Disease Prevention and Control, Suzhou, Jiangsu 215004, China. FAU - Liang, Fei AU - Liang F AD - Huzhou First People's Hospital, Huzhou, Zhejiang 313000, China; Department of Epidemiology and Health Statistics, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou, Jiangsu 215123, China. FAU - Yin, Jieyun AU - Yin J AD - Department of Epidemiology and Health Statistics, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou, Jiangsu 215123, China. FAU - Li, Xiaoliang AU - Li X AD - Zhuhai Center for Chronic Disease Control and Prevention, Zhuhai, Guangdong 519060, China. FAU - Jiang, Lai AU - Jiang L AD - Suzhou Center for Disease Prevention and Control, Suzhou, Jiangsu 215004, China. FAU - Gao, Yan AU - Gao Y AD - Suzhou Center for Disease Prevention and Control, Suzhou, Jiangsu 215004, China. FAU - Lu, Yan AU - Lu Y AD - Suzhou Center for Disease Prevention and Control, Suzhou, Jiangsu 215004, China. FAU - Hu, Yihe AU - Hu Y AD - Suzhou Center for Disease Prevention and Control, Suzhou, Jiangsu 215004, China. FAU - Dai, Ningbin AU - Dai N AD - Suzhou Center for Disease Prevention and Control, Suzhou, Jiangsu 215004, China. FAU - Su, Jian AU - Su J AD - Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu 210009, China. FAU - Yang, Zhuoqiao AU - Yang Z AD - Department of Epidemiology and Health Statistics, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou, Jiangsu 215123, China. FAU - Yao, Mengxin AU - Yao M AD - Department of Epidemiology and Health Statistics, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou, Jiangsu 215123, China. FAU - Xiao, Yue AU - Xiao Y AD - Department of Epidemiology and Health Statistics, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou, Jiangsu 215123, China. FAU - Ge, Wenxin AU - Ge W AD - Department of Epidemiology and Health Statistics, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou, Jiangsu 215123, China. FAU - Zhang, Yue AU - Zhang Y AD - Department of Epidemiology and Health Statistics, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou, Jiangsu 215123, China. FAU - Zhong, Yi AU - Zhong Y AD - Department of Epidemiology and Health Statistics, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou, Jiangsu 215123, China. FAU - Zhang, Jun AU - Zhang J AD - Suzhou Center for Disease Prevention and Control, Suzhou, Jiangsu 215004, China. Electronic address: sz_zhangj@163.com. FAU - Wu, Ming AU - Wu M AD - Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu 210009, China. Electronic address: jswuming@vip.sina.com. LA - eng PT - Journal Article DEP - 20240221 PL - Scotland TA - Growth Horm IGF Res JT - Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society JID - 9814320 RN - 0 (Insulin) RN - 0 (insulin-like growth factor binding protein-related protein 1) SB - IM MH - Humans MH - China MH - Cross-Sectional Studies MH - *Diabetes Complications/complications MH - *Diabetes Mellitus, Type 2/complications MH - Insulin OTO - NOTNLM OT - Diabetic complications OT - Duration OT - IGFBP7 OT - Type 2 diabetes mellitus COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/03/20 00:42 MHDA- 2024/04/01 06:43 CRDT- 2024/03/19 19:06 PHST- 2023/06/07 00:00 [received] PHST- 2023/10/31 00:00 [revised] PHST- 2024/02/20 00:00 [accepted] PHST- 2024/04/01 06:43 [medline] PHST- 2024/03/20 00:42 [pubmed] PHST- 2024/03/19 19:06 [entrez] AID - S1096-6374(24)00004-2 [pii] AID - 10.1016/j.ghir.2024.101574 [doi] PST - ppublish SO - Growth Horm IGF Res. 2024 Apr;75:101574. doi: 10.1016/j.ghir.2024.101574. Epub 2024 Feb 21.