PMID- 38503211 OWN - NLM STAT- MEDLINE DCOM- 20240408 LR - 20240425 IS - 1873-3336 (Electronic) IS - 0304-3894 (Linking) VI - 469 DP - 2024 May 5 TI - Prenatal exposure to poly/perfluoroalkyl substances and risk for congenital heart disease in offspring. PG - 134008 LID - S0304-3894(24)00587-9 [pii] LID - 10.1016/j.jhazmat.2024.134008 [doi] AB - Congenital heart disease (CHD) is the most prevalent congenital malformation worldwide, and the association between per- and polyfluoroalkyl substances (PFASs) exposure and CHD in population has only received limited study. Therefore, we conducted a multicenter case-control study to explore the associations between prenatal exposure to individual PFASs, and also a PFAS mixture, and CHD risk, including 185 CHDs and 247 controls in China from 2016 to 2021. Thirteen PFASs in maternal plasma were quantified using liquid chromatography-tandem mass spectrometry. Logistic regression and two multipollutant models (Bayesian kernel machine regression [BKMR] and quantile g-computation [qgcomp]) were used to assess the potential associations between any individual PFAS, and also a PFAS mixture, and CHD risk. After adjusting for potential confounders, logistic regression indicated significant associations between elevated levels of perfluorononanoic acid (odds ratio [OR]= 1.30, 95% confidence intervals [CI]: 1.07-1.58), perfluorodecanoic acid (OR=2.07, 95%CI: 1.32-3.26), and perfluoroundecanoic acid (OR=2.86, 95%CI:1.45-5.65) and CHD risk. The BKMR model and qgcomp approach identified that a significant positive association between the PFAS mixture and risk for CHD. These findings provide essential evidence that there is indeed a health crisis associated with PFASs and that it is linked to CHD. CI - Copyright (c) 2024 Elsevier B.V. All rights reserved. FAU - Li, Sainan AU - Li S AD - Institute of Reproductive and Child Health, National Health Commission Key Laboratory of Reproductive Health, Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. FAU - Wang, Chengrong AU - Wang C AD - Institute of Reproductive and Child Health, National Health Commission Key Laboratory of Reproductive Health, Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. FAU - Yang, Chen AU - Yang C AD - Institute of Reproductive and Child Health, National Health Commission Key Laboratory of Reproductive Health, Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. FAU - Chen, Yongyan AU - Chen Y AD - Institute of Reproductive and Child Health, National Health Commission Key Laboratory of Reproductive Health, Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. FAU - Cheng, Qianhui AU - Cheng Q AD - Institute of Reproductive and Child Health, National Health Commission Key Laboratory of Reproductive Health, Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. FAU - Liu, Jufen AU - Liu J AD - Institute of Reproductive and Child Health, National Health Commission Key Laboratory of Reproductive Health, Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. FAU - Zhang, Yali AU - Zhang Y AD - Institute of Reproductive and Child Health, National Health Commission Key Laboratory of Reproductive Health, Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. FAU - Jin, Lei AU - Jin L AD - Institute of Reproductive and Child Health, National Health Commission Key Laboratory of Reproductive Health, Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. FAU - Li, Zhiwen AU - Li Z AD - Institute of Reproductive and Child Health, National Health Commission Key Laboratory of Reproductive Health, Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. FAU - Ren, Aiguo AU - Ren A AD - Institute of Reproductive and Child Health, National Health Commission Key Laboratory of Reproductive Health, Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. FAU - Wang, Linlin AU - Wang L AD - Institute of Reproductive and Child Health, National Health Commission Key Laboratory of Reproductive Health, Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. Electronic address: linlinwang@bjmu.edu.cn. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20240313 PL - Netherlands TA - J Hazard Mater JT - Journal of hazardous materials JID - 9422688 RN - 0 (Environmental Pollutants) RN - 0 (Fluorocarbons) RN - 0 (Alkanesulfonic Acids) SB - IM MH - Pregnancy MH - Female MH - Humans MH - *Environmental Pollutants/toxicity MH - *Prenatal Exposure Delayed Effects/epidemiology MH - Bayes Theorem MH - Case-Control Studies MH - *Fluorocarbons/toxicity MH - *Heart Defects, Congenital/chemically induced/epidemiology MH - *Alkanesulfonic Acids OTO - NOTNLM OT - Bayesian kernel machine regression (BKMR) OT - Congenital heart disease (CHD) OT - Multicenter OT - Per- and polyfluoroalkyl substances (PFASs) OT - Quantile g-computation (qgcomp) COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/03/20 00:42 MHDA- 2024/04/08 06:43 CRDT- 2024/03/19 19:11 PHST- 2024/01/30 00:00 [received] PHST- 2024/02/26 00:00 [revised] PHST- 2024/03/09 00:00 [accepted] PHST- 2024/04/08 06:43 [medline] PHST- 2024/03/20 00:42 [pubmed] PHST- 2024/03/19 19:11 [entrez] AID - S0304-3894(24)00587-9 [pii] AID - 10.1016/j.jhazmat.2024.134008 [doi] PST - ppublish SO - J Hazard Mater. 2024 May 5;469:134008. doi: 10.1016/j.jhazmat.2024.134008. Epub 2024 Mar 13.