PMID- 38503411
OWN - NLM
STAT- MEDLINE
DCOM- 20240321
LR  - 20240322
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 14
IP  - 3
DP  - 2024 Mar 18
TI  - Association of thyroid autoantibodies and diabetic kidney disease in hospitalised 
      patients with type 2 diabetes mellitus: a cross-sectional study from a Chinese 
      university hospital.
PG  - e077338
LID - 10.1136/bmjopen-2023-077338 [doi]
LID - e077338
AB  - OBJECTIVES: To analyse and explore the association between thyroid autoantibodies 
      and diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus 
      (T2DM). DESIGN: A cross-sectional study. SETTING: Patients were from the 
      inpatient unit at The Second Endocrinology Department of Shengjing Hospital 
      Affiliated to China Medical University (Shenyang, China) between January 2015 and 
      September 2019. PARTICIPANTS: A total of 150 Chinese adults with T2DM were 
      included in the study, including 83 men and 67 women. Their age ranged between 25 
      and 92 years. METHODOLOGY: They grouped by the presence of DKD, urine 
      albumin-to-creatinine ratio (UACR), estimated glomerular filtration rate, and 
      levels of thyroid peroxidase antibodies (TPOAb) and thyroglobulin antibodies 
      (TgAb). Data on the patients' general characteristics and laboratory measurements 
      (levels of fasting plasma glucose, glycated haemoglobin, and albumin; renal 
      function; and thyroid function) were collected. Binary logistic regression was 
      performed to identify risk factors for DKD. RESULTS: The level of TPOAb, the 
      positivity rates of TPOAb (p<0.01) and TgAb (p<0.05) were higher in patients with 
      DKD than in those without DKD. The TPOAb level in patients with a UACR<30 mg/g 
      creatinine was lower than that in patients with a UACR between 30 and 300 mg/g 
      creatinine (p<0.05). The prevalence of DKD was higher in patients with a 
      TPOAb-positive or TgAb-positive status. The result of binary logistic regression 
      analysis showed that a TPOAb-positive status was significantly associated with 
      DKD in patients with T2DM (OR=7.683, 95% CI 1.583 to 37.286, p<0.05). 
      CONCLUSIONS: TPOAb-positive status is in association with DKD in patients with 
      T2DM. Large scale, prospective cohort studies are warranted to confirm our 
      findings.
CI  - (c) Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No 
      commercial re-use. See rights and permissions. Published by BMJ.
FAU - Wang, Zhi
AU  - Wang Z
AUID- ORCID: 0000-0002-7405-3872
AD  - Department of Endocrinology, Shengjing Hospital of China Medical University, 
      Shenyang, China.
FAU - Wang, Futao
AU  - Wang F
AD  - Department of Endocrinology, Changchun Center Hospital, Changchun, China.
FAU - Liu, Cong
AU  - Liu C
AD  - Department of Endocrinology, Shengjing Hospital of China Medical University, 
      Shenyang, China.
FAU - Zhang, Le
AU  - Zhang L
AD  - Department of Endocrinology, Shengjing Hospital of China Medical University, 
      Shenyang, China zhangle198626@163.com.
LA  - eng
PT  - Journal Article
DEP - 20240318
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
RN  - EC 1.11.1.8 (Iodide Peroxidase)
RN  - AYI8EX34EU (Creatinine)
RN  - 0 (Autoantibodies)
RN  - 0 (Albumins)
SB  - IM
MH  - Adult
MH  - Male
MH  - Humans
MH  - Female
MH  - Middle Aged
MH  - Aged
MH  - Aged, 80 and over
MH  - Thyroid Gland
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Cross-Sectional Studies
MH  - *Diabetic Nephropathies
MH  - Iodide Peroxidase
MH  - Prospective Studies
MH  - Creatinine
MH  - Autoantibodies
MH  - Hospitals
MH  - Albumins
PMC - PMC10952948
OTO - NOTNLM
OT  - diabetes & endocrinology
OT  - diabetic nephropathy & vascular disease
OT  - thyroid disease
COIS- Competing interests: None declared.
EDAT- 2024/03/20 00:42
MHDA- 2024/03/21 12:47
PMCR- 2024/03/18
CRDT- 2024/03/19 20:32
PHST- 2024/03/21 12:47 [medline]
PHST- 2024/03/20 00:42 [pubmed]
PHST- 2024/03/19 20:32 [entrez]
PHST- 2024/03/18 00:00 [pmc-release]
AID - bmjopen-2023-077338 [pii]
AID - 10.1136/bmjopen-2023-077338 [doi]
PST - epublish
SO  - BMJ Open. 2024 Mar 18;14(3):e077338. doi: 10.1136/bmjopen-2023-077338.