PMID- 38504407
OWN - NLM
STAT- MEDLINE
DCOM- 20240321
LR  - 20240321
IS  - 1536-4801 (Electronic)
IS  - 0277-2116 (Linking)
VI  - 78
IP  - 3
DP  - 2024 Mar
TI  - Role of peripheral and tissue eosinophils and eosinophil cationic protein in 
      pediatric inflammatory bowel disease.
PG  - 653-661
LID - 10.1002/jpn3.12076 [doi]
AB  - OBJECTIVES: Inflammatory bowel disease (IBD), eosinophilic gastrointestinal 
      disease (EGID), and functional abdominal pain disorder (FAPD) present with 
      nonspecific gastrointestinal (GI) symptoms clinically and also have some 
      similarities in pathogeneses associated with eosinophils. Therefore, we aimed to 
      evaluate the role of eosinophils in IBD compared to EGID and FAPD by 
      investigating eosinophils in peripheral blood and GI tissue and eosinophil 
      cationic protein (ECP). METHODS: Pediatric patients with chronic GI symptoms who 
      underwent endoscopic biopsies were enrolled. Complete blood cell counts, 
      inflammatory markers, immunoglobulin E (IgE), serum ECP levels, and endoscopic 
      and histopathologic findings were retrospectively reviewed. RESULTS: A total of 
      387 patients were included: 179 with EGID, 107 with IBDs, and 82 with FAPD. 
      Peripheral absolute eosinophil count (AEC), total IgE, and serum ECP were 
      significantly higher in both IBD and EGID than in FAPD (all p < 0.05). 
      Statistically significant differences were noted among the three groups in tissue 
      eosinophil counts in each segment of GI tract except for the esophagus 
      (p < 0.05). Significant differences were observed in tissue eosinophil counts in 
      the ascending, sigmoid colon, and rectum between EGID and IBD (p < 0.05). 
      Peripheral and tissue eosinophils in the stomach and duodenum revealed positive 
      correlation in both EGID and IBD (both p < 0.001). CONCLUSION: Elevated 
      eosinophil-related markers, as well as increased tissue eosinophilic infiltration 
      in the affected areas of the GI tract in both IBD and EGID compared to FAPD, 
      suggest that eosinophils might play a common important role in the pathogeneses 
      of both diseases.
CI  - (c) 2023 European Society for Pediatric Gastroenterology, Hepatology, and Nutrition 
      and North American Society for Pediatric Gastroenterology, Hepatology, and 
      Nutrition.
FAU - Kim, You Ie
AU  - Kim YI
AUID- ORCID: 0000-0002-6839-9244
AD  - Department of Pediatrics, Seoul National University College of Medicine, Seoul, 
      Republic of Korea.
AD  - Department of Pediatrics, Incheon St. Mary's Hospital, College of Medicine, The 
      Catholic University of Korea, Seoul, Republic of Korea.
FAU - Yang, Hye Ran
AU  - Yang HR
AD  - Department of Pediatrics, Seoul National University College of Medicine, Seoul, 
      Republic of Korea.
AD  - Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, 
      Republic of Korea.
LA  - eng
GR  - None/
PT  - Journal Article
DEP - 20231210
PL  - United States
TA  - J Pediatr Gastroenterol Nutr
JT  - Journal of pediatric gastroenterology and nutrition
JID - 8211545
RN  - EC 3.1.27.- (Eosinophil Cationic Protein)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - Eosinophilic enteropathy
SB  - IM
MH  - Humans
MH  - Child
MH  - *Eosinophils/pathology
MH  - Eosinophil Cationic Protein
MH  - Retrospective Studies
MH  - *Inflammatory Bowel Diseases/pathology
MH  - Immunoglobulin E
MH  - Leukocyte Count
MH  - *Enteritis
MH  - *Eosinophilia
MH  - *Gastritis
OTO - NOTNLM
OT  - eosinophil
OT  - eosinophilic enteropathy
OT  - functional abdominal pain disorder
OT  - inflammatory bowel disease
EDAT- 2024/03/20 06:45
MHDA- 2024/03/21 12:45
CRDT- 2024/03/20 00:59
PHST- 2023/11/06 00:00 [revised]
PHST- 2023/09/06 00:00 [received]
PHST- 2023/11/20 00:00 [accepted]
PHST- 2024/03/21 12:45 [medline]
PHST- 2024/03/20 06:45 [pubmed]
PHST- 2024/03/20 00:59 [entrez]
AID - 10.1002/jpn3.12076 [doi]
PST - ppublish
SO  - J Pediatr Gastroenterol Nutr. 2024 Mar;78(3):653-661. doi: 10.1002/jpn3.12076. 
      Epub 2023 Dec 10.