PMID- 38505029
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240321
IS  - 2072-1439 (Print)
IS  - 2077-6624 (Electronic)
IS  - 2072-1439 (Linking)
VI  - 16
IP  - 2
DP  - 2024 Feb 29
TI  - Low-normal free triiodothyronine as a predictor of post-operative atrial 
      fibrillation after surgical coronary revascularization.
PG  - 1191-1200
LID - 10.21037/jtd-23-1646 [doi]
AB  - BACKGROUND: Recent studies have focused on the association between thyroid 
      function within normal range and cardiovascular diseases, especially on free 
      triiodothyronine (FT3) levels. This study aims to evaluate the effects of normal 
      FT3 level on new-onset atrial fibrillation (AF) in patients with surgical 
      coronary revascularization. METHODS: The patients who underwent surgical coronary 
      revascularization were enrolled in the retrospective study. Thyroid function was 
      tested after an overnight fast on the first morning of hospitalization. Serum FT3 
      level was divided into quartile groups within the normal range. Hazards ratios 
      (HRs) of FT3 level for AF were analyzed by COX proportional hazard model. 
      RESULTS: This study included 503 patients with a mean [standard deviation (SD)] 
      age of 63 (+/-9) years, and 396 (78.73%) were male. Post-operative AF (POAF) 
      occurred in 120 (23.86%) patients at a median of two days after surgical coronary 
      revascularization. The cumulating incidence of AF was significantly higher in the 
      FT3 quartile 1 (Q1) group especially in older patients as evidenced by 
      Kaplan-Meier analysis. Additionally, the patients who experienced AF had longer 
      hospital stays, the same result was also found in the FT3 Q1 group. Further study 
      demonstrated that low-normal FT3 was an independent predictor of POAF [HR =1.52, 
      95% confidence interval (CI): 1.01, 2.28, P=0.045]. CONCLUSIONS: Low-normal FT3 
      is associated with an increased risk of POAF and is an independent predictor of 
      POAF. Patients who experienced AF have longer hospital stays. The findings may 
      help to identify patients with surgical coronary revascularization at a higher 
      risk for the development of AF.
CI  - 2024 Journal of Thoracic Disease. All rights reserved.
FAU - Hua, Cuncun
AU  - Hua C
AD  - Department of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, 
      Beijing, China.
FAU - Liu, Pengfei
AU  - Liu P
AD  - Department of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, 
      Beijing, China.
FAU - Zhang, Min
AU  - Zhang M
AD  - Department of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, 
      Beijing, China.
FAU - Niu, Jiayin
AU  - Niu J
AD  - Department of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, 
      Beijing, China.
FAU - Wang, Lefeng
AU  - Wang L
AD  - Department of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, 
      Beijing, China.
FAU - Zhong, Guangzhen
AU  - Zhong G
AD  - Department of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, 
      Beijing, China.
AD  - Research Ward, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20240224
PL  - China
TA  - J Thorac Dis
JT  - Journal of thoracic disease
JID - 101533916
PMC - PMC10944733
OTO - NOTNLM
OT  - Atrial fibrillation (AF)
OT  - free triiodothyronine (FT3)
OT  - predictor
OT  - surgical coronary revascularization
COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure 
      form (available at 
      https://jtd.amegroups.com/article/view/10.21037/jtd-23-1646/coif). The authors 
      have no conflicts of interest to declare.
EDAT- 2024/03/20 06:45
MHDA- 2024/03/20 06:46
PMCR- 2024/02/29
CRDT- 2024/03/20 04:02
PHST- 2023/10/27 00:00 [received]
PHST- 2024/01/05 00:00 [accepted]
PHST- 2024/03/20 06:46 [medline]
PHST- 2024/03/20 06:45 [pubmed]
PHST- 2024/03/20 04:02 [entrez]
PHST- 2024/02/29 00:00 [pmc-release]
AID - jtd-16-02-1191 [pii]
AID - 10.21037/jtd-23-1646 [doi]
PST - ppublish
SO  - J Thorac Dis. 2024 Feb 29;16(2):1191-1200. doi: 10.21037/jtd-23-1646. Epub 2024 
      Feb 24.