PMID- 38506861
OWN - NLM
STAT- MEDLINE
DCOM- 20240321
LR  - 20240321
IS  - 2448-9190 (Electronic)
IS  - 0002-5151 (Linking)
VI  - 70
IP  - 4
DP  - 2023 Dec 31
TI  - [Physiopathology of food allergies].
PG  - 225-229
LID - 10.29262/ram.v70i4.1309 [doi]
AB  - Food allergy is an adverse reaction to certain foods that have demonstrated 
      "immunological mechanisms"; therefore, this term covers both food allergies 
      mediated or not by immunoglobulin E (IgE). The common pathophysiological 
      mechanism among forms of allergy to foods mediated or not by IgE is found in the 
      failure of clinical and immunological tolerance towards that food. The induction 
      and maintenance of immunological tolerance depends on the active generation of 
      regulatory T cells specific for food antigens. This process is influenced by 
      genetic factors (FOXP3 genes) and epigenetic factors conditioned by the 
      environment (diet, microbiota, and their products). Since the intestinal 
      microbiome can normally promote oral tolerance, current evidence suggests that 
      perturbations of the microbiome may correlate, or even predispose, with food 
      allergy. Understanding the pathogenic mechanism underlying IgE-mediated food 
      allergies allows the implementation of measures aimed at restoring clinical and 
      immunological tolerance. Knowledge of the mechanisms of food allergy will improve 
      the outlook for patients with more severe immediate food allergies and 
      anaphylaxis, as well as those who have comorbidities (atopic dermatitis, 
      eosinophilic esophagitis and EGEIDs).
FAU - Valentin Rostan, Marylin
AU  - Valentin Rostan M
AUID- ORCID: 0000-0002-0782-9386
AD  - Pediatra, Alergologa e Inmunologa; Profesora de Alergia pediatrica, Facultad de 
      Medicina Uruguay; Presidenta electa de la Sociedad Latinoamericana de Alergia, 
      Asma e Inmunologia (SLAAI), Montevideo, Uruguay. dramarylinvalentin@gmail.com.
FAU - Bogado, Dory Mora
AU  - Bogado DM
AUID- ORCID: 0000-0002-4914-4473
AD  - Alergologa e Inmunologa, Medica del Area de Alergologia, Hospital Central-IPS, 
      Asuncion, Paraguay.
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Fisiopatologia de la alergia alimentaria.
DEP - 20231231
PL  - Mexico
TA  - Rev Alerg Mex
JT  - Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)
JID - 9438824
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Humans
MH  - *Food Hypersensitivity/etiology
MH  - Food
MH  - *Anaphylaxis
MH  - *Dermatitis, Atopic
MH  - Immunoglobulin E
OTO - NOTNLM
OT  - Atopic dermatitis
OT  - Eosinophilic esophagitis
OT  - Food allergy
OT  - IgE-mediated allergy
OT  - Immunological mechanisms
OT  - Microbiome
OT  - Non-IgE-mediated allergy
OT  - T cells
EDAT- 2024/03/20 12:43
MHDA- 2024/03/21 12:44
CRDT- 2024/03/20 11:43
PHST- 2023/08/01 00:00 [received]
PHST- 2023/10/29 00:00 [accepted]
PHST- 2024/03/21 12:44 [medline]
PHST- 2024/03/20 12:43 [pubmed]
PHST- 2024/03/20 11:43 [entrez]
AID - 10.29262/ram.v70i4.1309 [doi]
PST - epublish
SO  - Rev Alerg Mex. 2023 Dec 31;70(4):225-229. doi: 10.29262/ram.v70i4.1309.