PMID- 38506925
OWN - NLM
STAT- MEDLINE
DCOM- 20240322
LR  - 20240323
IS  - 1438-2199 (Electronic)
IS  - 0939-4451 (Print)
IS  - 0939-4451 (Linking)
VI  - 56
IP  - 1
DP  - 2024 Mar 20
TI  - An insight into role of amino acids as antioxidants via NRF2 activation.
PG  - 23
LID - 10.1007/s00726-024-03384-8 [doi]
LID - 23
AB  - Oxidative stress can affect the protein, lipids, and DNA of the cells and thus, 
      play a crucial role in several pathophysiological conditions. It has already been 
      established that oxidative stress has a close association with inflammation via 
      nuclear factor erythroid 2-related factor 2 (NRF2) signaling pathway. Amino acids 
      are notably the building block of proteins and constitute the major class of 
      nitrogen-containing natural products of medicinal importance. They exhibit a 
      broad spectrum of biological activities, including the ability to activate NRF2, 
      a transcription factor that regulates endogenous antioxidant responses. Moreover, 
      amino acids may act as synergistic antioxidants as part of our dietary 
      supplementations. This has aroused research interest in the NRF2-inducing 
      activity of amino acids. Interestingly, amino acids' activation of 
      NRF2-Kelch-like ECH-associated protein 1 (KEAP1) signaling pathway exerts 
      therapeutic effects in several diseases. Therefore, the present review will 
      discuss the relationship between different amino acids and activation of 
      NRF2-KEAP1 signaling pathway pinning their anti-inflammatory and antioxidant 
      properties. We also discussed amino acids formulations and their applications as 
      therapeutics. This will broaden the prospect of the therapeutic applications of 
      amino acids in a myriad of inflammation and oxidative stress-related diseases. 
      This will provide an insight for designing and developing new chemical entities 
      as NRF2 activators.
CI  - (c) 2024. The Author(s).
FAU - Egbujor, Melford C
AU  - Egbujor MC
AUID- ORCID: 0000-0002-0477-4586
AD  - Department of Chemistry, Federal University Otuoke, Otuoke, Bayelsa, Nigeria.
FAU - Olaniyan, Olugbemi T
AU  - Olaniyan OT
AUID- ORCID: 0000-0002-6327-8435
AD  - Department of Physiology, Rhema University Nigeria, Aba, Abia, Nigeria.
FAU - Emeruwa, Chigbundu N
AU  - Emeruwa CN
AUID- ORCID: 0000-0003-3770-9542
AD  - Department of Chemistry, Rhema University Nigeria, Aba, Abia, Nigeria.
FAU - Saha, Sarmistha
AU  - Saha S
AUID- ORCID: 0000-0001-5324-1957
AD  - Department of Biotechnology, Institute of Applied Sciences and Humanities, GLA 
      University, Mathura, 281406, India.
FAU - Saso, Luciano
AU  - Saso L
AUID- ORCID: 0000-0003-4530-8706
AD  - Department of Physiology and Pharmacology, Vittorio Erspamer, Sapienza University 
      of Rome, 00161, Rome, Italy. luciano.saso@uniroma1.it.
FAU - Tucci, Paolo
AU  - Tucci P
AUID- ORCID: 0000-0001-7314-445X
AD  - Department of Clinical and Experimental Medicine, University of Foggia, 71122, 
      Foggia, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20240320
PL  - Austria
TA  - Amino Acids
JT  - Amino acids
JID - 9200312
RN  - 0 (Antioxidants)
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (Kelch-Like ECH-Associated Protein 1)
RN  - 0 (Amino Acids)
SB  - IM
MH  - Humans
MH  - *Antioxidants/metabolism
MH  - *NF-E2-Related Factor 2/genetics/metabolism
MH  - Kelch-Like ECH-Associated Protein 1/genetics/chemistry/metabolism
MH  - Amino Acids/metabolism
MH  - Oxidative Stress
MH  - Inflammation/drug therapy
PMC - PMC10954862
OTO - NOTNLM
OT  - Amino acids
OT  - Anti-inflammatory
OT  - Antioxidant
OT  - NRF2-KEAP1 signaling
OT  - Oxidative stress
COIS- The authors declare no competing interests. The authors declare no conflicts of 
      interest.
EDAT- 2024/03/20 18:45
MHDA- 2024/03/22 06:44
PMCR- 2024/03/20
CRDT- 2024/03/20 12:02
PHST- 2023/07/07 00:00 [received]
PHST- 2024/01/31 00:00 [accepted]
PHST- 2024/03/22 06:44 [medline]
PHST- 2024/03/20 18:45 [pubmed]
PHST- 2024/03/20 12:02 [entrez]
PHST- 2024/03/20 00:00 [pmc-release]
AID - 10.1007/s00726-024-03384-8 [pii]
AID - 3384 [pii]
AID - 10.1007/s00726-024-03384-8 [doi]
PST - epublish
SO  - Amino Acids. 2024 Mar 20;56(1):23. doi: 10.1007/s00726-024-03384-8.