PMID- 38507082
OWN - NLM
STAT- Publisher
LR  - 20240320
IS  - 1432-5233 (Electronic)
IS  - 0940-5429 (Linking)
DP  - 2024 Mar 20
TI  - Associations of muscle mass and strength with new-onset diabetes among 
      middle-aged and older adults: evidence from the China health and retirement 
      longitudinal study (CHARLS).
LID - 10.1007/s00592-024-02265-6 [doi]
AB  - BACKGROUND: The associations of muscle mass and strength with new-onset Type 2 
      diabetes mellitus (T2DM) remain controversial. We aimed to longitudinally 
      evaluate muscle mass and strength in predicting T2DM among Chinese middle-aged 
      and older adults. METHODS: We enrolled 6033 participants aged >/= 45 years from the 
      China Health and Retirement Longitudinal Study (CHARLS), a cohort survey, between 
      2011 and 2012. The appendicular skeletal muscle mass (normalized by weight, 
      ASM/BW%), relative hand grip strength (normalized by weight, HGS/BW), and 
      five-repetition chair stand test (5CST). were all categorized into tertiles 
      (lowest, middle, and highest groups) at baseline, respectively. Individuals were 
      followed up until the occurrence of diabetes or the end of CHARLS 2018, whichever 
      happened first. Cox proportional hazards models to calculate hazard ratios with 
      95% confidence intervals (CI) and mediation analysis were used. RESULTS: During 
      follow-up, 815 (13.5%) participants developed T2DM. After adjusting for 
      covariates, lower ASW/BW% was not associated with a higher risk of diabetes. 
      Compared with individuals in the highest tertile of HGS/BW, those in the lowest 
      tertile had 1.296 (95%CI 1.073-1.567) higher risk of diabetes. Compared with 
      individuals in the lowest tertile of 5CST, those in the highest tertile had 1.329 
      times (95%CI 1.106-1.596) higher risk of diabetes. By subgroup, both the lowest 
      HGS/BW and highest 5CST were risk factors for diabetes among obesity. The 
      mediation analysis revealed that the effect of HGS/BW on the risk of diabetes is 
      mainly mediated by insulin resistance. CONCLUSIONS: Lower muscle strength is 
      associated with an increased risk of diabetes, especially in obese populations.
CI  - (c) 2024. Springer-Verlag Italia S.r.l., part of Springer Nature.
FAU - He, Yun-Yun
AU  - He YY
AUID- ORCID: 0000-0002-9151-7122
AD  - Department of General Medicine, Beijing Chao-yang Hospital, Capital Medical 
      University, Beijing, 100020, China.
FAU - Jin, Mei-Ling
AU  - Jin ML
AD  - Department of Nephrology, Beijing Chao-yang Hospital, Capital Medical University, 
      Beijing, 100020, China.
FAU - Fang, Xiang-Yang
AU  - Fang XY
AD  - Department of General Medicine, Beijing Chao-yang Hospital, Capital Medical 
      University, Beijing, 100020, China.
FAU - Wang, Xiao-Juan
AU  - Wang XJ
AD  - Department of General Medicine, Beijing Chao-yang Hospital, Capital Medical 
      University, Beijing, 100020, China. xjwang730715@sina.com.
LA  - eng
PT  - Journal Article
DEP - 20240320
PL  - Germany
TA  - Acta Diabetol
JT  - Acta diabetologica
JID - 9200299
SB  - IM
OTO - NOTNLM
OT  - CHARLS
OT  - Middle-aged and elderly
OT  - Muscle mass
OT  - Muscle strength
OT  - Type 2 diabetes mellitus
EDAT- 2024/03/20 18:45
MHDA- 2024/03/20 18:45
CRDT- 2024/03/20 12:14
PHST- 2023/04/11 00:00 [received]
PHST- 2024/02/27 00:00 [accepted]
PHST- 2024/03/20 18:45 [medline]
PHST- 2024/03/20 18:45 [pubmed]
PHST- 2024/03/20 12:14 [entrez]
AID - 10.1007/s00592-024-02265-6 [pii]
AID - 10.1007/s00592-024-02265-6 [doi]
PST - aheadofprint
SO  - Acta Diabetol. 2024 Mar 20. doi: 10.1007/s00592-024-02265-6.