PMID- 38507904 OWN - NLM STAT- MEDLINE DCOM- 20240322 LR - 20240322 IS - 1833-3516 (Print) IS - 1833-3516 (Linking) VI - 54 IP - 1 DP - 2024 Mar 31 TI - Efficacy of searching in biomedical databases beyond MEDLINE in identifying randomised controlled trials on hyperbaric oxygen treatment. PG - 2-8 LID - 10.28920/dhm54.1.2-8 [doi] AB - INTRODUCTION: Literature searches are routinely used by researchers for conducting systematic reviews as well as by healthcare providers, and sometimes patients, to quickly guide their clinical decisions. Using more than one database is generally recommended but may not always be necessary for some fields. This study aimed to determine the added value of searching additional databases beyond MEDLINE when conducting a literature search of hyperbaric oxygen treatment (HBOT) randomised controlled trials (RCTs). METHODS: This study consisted of two phases: a scoping review of all RCTs in the field of HBOT, followed by a a statistical analysis of sensitivity, precision, 'number needed to read' (NNR) and 'number unique' included by individual biomedical databases. MEDLINE, Embase, Cochrane Central Register of Control Trials (CENTRAL), and Cumulated Index to Nursing and Allied Health Literature (CINAHL) were searched without date or language restrictions up to December 31, 2022. Screening and data extraction were conducted in duplicate by pairs of independent reviewers. RCTs were included if they involved human subjects and HBOT was offered either on its own or in combination with other treatments. RESULTS: Out of 5,840 different citations identified, 367 were included for analysis. CENTRAL was the most sensitive (87.2%) and had the most unique references (7.1%). MEDLINE had the highest precision (23.8%) and optimal NNR (four). Among included references, 14.2% were unique to a single database. CONCLUSIONS: Systematic reviews of RCTs in HBOT should always utilise multiple databases, which at minimum include MEDLINE, Embase, CENTRAL and CINAHL. CI - Copyright: This article is the copyright of the authors who grant Diving and Hyperbaric Medicine a non-exclusive licence to publish the article in electronic and other forms. FAU - Khan, Hira AU - Khan H AD - Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada. FAU - Islam, Mohammad Sindeed AU - Islam MS AD - Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada. FAU - Kaur, Manvinder AU - Kaur M AD - Department of Anesthesiology and Pain Medicine, The Ottawa Hospital, Ottawa, ON, Canada. FAU - Burns, Joseph K AU - Burns JK AD - Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada. AD - Department of Anesthesiology and Pain Medicine, The Ottawa Hospital, Ottawa, ON, Canada. FAU - Etherington, Cole AU - Etherington C AD - Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada. AD - Department of Anesthesiology and Pain Medicine, The Ottawa Hospital, Ottawa, ON, Canada. FAU - Dion, Pierre-Marc AU - Dion PM AD - Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada. FAU - Alsayadi, Sarah AU - Alsayadi S AD - Faculty of Science, University of Ottawa, Ottawa, ON, Canada. FAU - Boet, Sylvain AU - Boet S AD - Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada. AD - Department of Anesthesiology and Pain Medicine, The Ottawa Hospital, Ottawa, ON, Canada. AD - Department of Innovation in Medical Education, University of Ottawa, Ottawa, ON, Canada. AD - Institut du Savoir Montfort, Ottawa, ON, Canada. AD - Corresponding author: Dr Sylvain Boet, 1053 Carling Avenue, Ottawa, ON K1Y 4E9, ON, Canada, sboet@toh.ca. LA - eng PT - Journal Article PT - Review PL - Australia TA - Diving Hyperb Med JT - Diving and hyperbaric medicine JID - 101282742 RN - S88TT14065 (Oxygen) SB - IM MH - Humans MH - *Hyperbaric Oxygenation MH - MEDLINE MH - Oxygen MH - Randomized Controlled Trials as Topic OTO - NOTNLM OT - Biomedical databases OT - Research methods OT - Systematic review EDAT- 2024/03/21 00:44 MHDA- 2024/03/22 06:44 CRDT- 2024/03/20 19:06 PHST- 2022/10/27 00:00 [received] PHST- 2023/11/25 00:00 [accepted] PHST- 2024/03/22 06:44 [medline] PHST- 2024/03/21 00:44 [pubmed] PHST- 2024/03/20 19:06 [entrez] AID - 10.28920/dhm54.1.2-8 [doi] PST - ppublish SO - Diving Hyperb Med. 2024 Mar 31;54(1):2-8. doi: 10.28920/dhm54.1.2-8.