PMID- 38507906
OWN - NLM
STAT- MEDLINE
DCOM- 20240322
LR  - 20240322
IS  - 1833-3516 (Print)
IS  - 1833-3516 (Linking)
VI  - 54
IP  - 1
DP  - 2024 Mar 31
TI  - Effect of hyperbaric oxygen treatment on ischaemia-reperfusion injury in rats 
      detorsioned after experimental ovarian torsion.
PG  - 16-22
LID - 10.28920/dhm54.1.16-22 [doi]
AB  - INTRODUCTION: This study aimed to investigate whether hyperbaric oxygen treatment 
      (HBOT) could ameliorate ischaemia-reperfusion injury in a rat model of ovarian 
      torsion-detorsion. METHODS: Twenty-seven rats were divided among four groups: 
      surgical sham rats (S) (n = 6) underwent identical anaesthesia and surgical 
      incisions to other groups (n = 7 per group) but with no ovary intervention; 
      torsion rats (T) underwent laparotomy, ovarian torsion, relaparotomy and 
      sacrifice after three hours; torsion and detorsion rats (T/DT) underwent 
      laparotomy, ovarian torsion (three hours), relaparotomy and detorsion, and 
      sacrifice after one week; torsion, detorsion, hyperbaric oxygen rats (T/DT/HBOT) 
      underwent laparotomy, ovarian torsion, relaparotomy and detorsion, and sacrifice 
      after one week during which HBOT was provided 21 times (100% oxygen at 600 kPa 
      for 50 min). In all groups blood collection for markers of oxidative stress or 
      related responses, and ovary collection for histology were performed after 
      sacrifice. RESULTS: When the T/DT, and T/DT/HBOT groups were compared, 
      8-hydroxy-2'-deoxyguanosine (a marker of oxidative damage to DNA) and 
      malondialdehyde (a product of lipid peroxidation) levels were lower in the 
      T/DT/HBOT group. Anti-Mullerian hormone levels were higher in the T/DT/HBOT group 
      compared to the T/DT group. In addition, oedema, vascular occlusion, neutrophilic 
      infiltration and follicular cell damage were less in the T/DT/HBOT group than in 
      the T/DT group. CONCLUSIONS: When biochemical and histopathological findings were 
      evaluated together, HBOT appeared reduce ovarian ischaemia / reperfusion injury 
      in this rat model of ovarian torsion-detorsion.
CI  - Copyright: This article is the copyright of the authors who grant Diving and 
      Hyperbaric Medicine a non-exclusive licence to publish the article in electronic 
      and other forms.
FAU - Bulutlar, Eralp
AU  - Bulutlar E
AUID- ORCID: 0000-0002-2246-4899
AD  - Zeynep Kamil Gynecology and Obstetrics Training and Research Hospital, Istanbul, 
      Turkey.
AD  - Corresponding author: Dr Eralp Bulutlar, Basaksehir Cam and Sakura City Hospital, 
      Basaksehir Olimpiyat Bulvari Yolu, 34480 Basaksehir, Istanbul, Turkey, 
      eralpbulutlar@hotmail.com.
FAU - Yilmaz, Ali
AU  - Yilmaz A
AD  - Kartal Lutfu Kirdar Training and Research Hospital Istanbul, Turkey.
FAU - Uluutku Bulutlar, Gizem Berfin
AU  - Uluutku Bulutlar GB
AD  - Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.
FAU - Aslan, Yavuz
AU  - Aslan Y
AD  - Sultan Abdulhamid Han Research and Training Hospital.
FAU - Bozdag, Hale Nur
AU  - Bozdag HN
AD  - VM Medical Park Maltepe Hastanesi, Istanbul, Turkey.
FAU - Kucukodaci, Zafer
AU  - Kucukodaci Z
AD  - Anadolu Saglik Merkezi, Gebze, Kocaeli, Turkey.
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Diving Hyperb Med
JT  - Diving and hyperbaric medicine
JID - 101282742
RN  - 0 (Antioxidants)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Humans
MH  - Female
MH  - Rats
MH  - Animals
MH  - Ovarian Torsion/therapy
MH  - Rats, Wistar
MH  - Antioxidants
MH  - *Hyperbaric Oxygenation
MH  - Oxygen
MH  - *Reperfusion Injury/therapy
OTO - NOTNLM
OT  - Animal model
OT  - Antioxidants
OT  - Experimental
OT  - Hyperbaric research
OT  - Inflammation
EDAT- 2024/03/21 00:44
MHDA- 2024/03/22 06:44
CRDT- 2024/03/20 19:06
PHST- 2021/03/15 00:00 [received]
PHST- 2023/12/26 00:00 [accepted]
PHST- 2024/03/22 06:44 [medline]
PHST- 2024/03/21 00:44 [pubmed]
PHST- 2024/03/20 19:06 [entrez]
AID - 10.28920/dhm54.1.16-22 [doi]
PST - ppublish
SO  - Diving Hyperb Med. 2024 Mar 31;54(1):16-22. doi: 10.28920/dhm54.1.16-22.