PMID- 38507910
OWN - NLM
STAT- MEDLINE
DCOM- 20240322
LR  - 20240322
IS  - 1833-3516 (Print)
IS  - 1833-3516 (Linking)
VI  - 54
IP  - 1
DP  - 2024 Mar 31
TI  - Equipoise: an important ethical consideration when contemplating participation in 
      a randomised controlled trial of hyperbaric oxygen treatment in necrotising soft 
      tissue infections.
PG  - 57-60
LID - 10.28920/dhm54.1.57-60 [doi]
AB  - A proposal for a large, multi-centre, randomised controlled trial investigating 
      the role of hyperbaric oxygen treatment (HBOT) in necrotising soft tissue 
      infections (NSTI) has led to much discussion locally and internationally about 
      whether participation is ethical for a centre where stakeholders already consider 
      HBOT standard practice. This article systematically addresses the concept of 
      clinical equipoise specific to the role of HBOT in NSTI, and presents a series of 
      considerations to be taken into account by key stakeholders at potential 
      participating sites.
CI  - Copyright: This article is the copyright of the authors who grant Diving and 
      Hyperbaric Medicine a non-exclusive licence to publish the article in electronic 
      and other forms.
FAU - Devaney, Bridget
AU  - Devaney B
AUID- ORCID: 0000-0001-6521-418X
AD  - Emergency and Trauma Centre, Alfred Health, Melbourne, Australia.
AD  - Department of Intensive Care and Hyperbaric Medicine, Alfred Health, Melbourne, 
      Australia.
AD  - Department of Epidemiology and Preventative Medicine, Monash University, 
      Melbourne, Australia.
AD  - Corresponding author: Dr Bridget Devaney, Head of Hyperbaric Medicine, Alfred 
      Health, 55 Commercial Road, Melbourne, VIC 3004, Australia, 
      b.devaney@alfred.org.au.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PL  - Australia
TA  - Diving Hyperb Med
JT  - Diving and hyperbaric medicine
JID - 101282742
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Humans
MH  - *Soft Tissue Infections/therapy
MH  - *Hyperbaric Oxygenation
MH  - Oxygen
OTO - NOTNLM
OT  - Clinical trials
OT  - Ethics
OT  - Hyperbaric research
EDAT- 2024/03/21 00:44
MHDA- 2024/03/22 06:44
CRDT- 2024/03/20 19:06
PHST- 2023/11/17 00:00 [received]
PHST- 2024/01/19 00:00 [accepted]
PHST- 2024/03/22 06:44 [medline]
PHST- 2024/03/21 00:44 [pubmed]
PHST- 2024/03/20 19:06 [entrez]
AID - 10.28920/dhm54.1.57-60 [doi]
PST - ppublish
SO  - Diving Hyperb Med. 2024 Mar 31;54(1):57-60. doi: 10.28920/dhm54.1.57-60.