PMID- 38507912
OWN - NLM
STAT- MEDLINE
DCOM- 20240322
LR  - 20240322
IS  - 1833-3516 (Print)
IS  - 1833-3516 (Linking)
VI  - 54
IP  - 1
DP  - 2024 Mar 31
TI  - Hyperbaric oxygen for the treatment of carbon monoxide-induced delayed 
      neurological sequelae: a case report and review of the literature.
PG  - 65-68
LID - 10.28920/dhm54.1.65-68 [doi]
AB  - INTRODUCTION: Hyperbaric oxygen treatment (HBOT) remains a recognised treatment 
      for acute carbon monoxide (CO) poisoning, but the utility of HBOT in treating 
      CO-induced delayed neurological sequelae (DNS) is not yet established. CASE 
      DESCRIPTION: A 26-year old woman presented with reduced consciousness secondary 
      to CO exposure from burning charcoal. She underwent a single session of HBOT with 
      US Navy Treatment Table 5 within six hours of presentation, with full 
      neurological recovery. Eight weeks later, she represented with progressive, 
      debilitating neurological symptoms mimicking Parkinsonism. Magnetic resonance 
      imaging of her brain demonstrated changes consistent with hypoxic ischaemic 
      encephalopathy. The patient underwent 20 sessions of HBOT at 203 kPa (2 
      atmospheres absolute) for 115 minutes, and received intravenous 
      methylprednisolone 1 g per day for three days. The patient's neurological 
      symptoms completely resolved, and she returned to full-time professional work 
      with no further recurrence. DISCUSSION: Delayed neurological sequelae is a 
      well-described complication of CO poisoning. In this case, the patient's 
      debilitating neurocognitive symptoms resolved following HBOT. Existing literature 
      on treatment of CO-induced DNS with HBOT consists mainly of small-scale studies 
      and case reports, many of which similarly suggest that HBOT is effective in 
      treating this complication. However, a large, randomised trial is required to 
      adequately determine the effectiveness of HBOT in the treatment of CO-induced 
      DNS, and an optimal treatment protocol.
CI  - Copyright: This article is the copyright of the authors who grant Diving and 
      Hyperbaric Medicine a non-exclusive licence to publish the article in electronic 
      and other forms.
FAU - Wong, Zebedee Kr
AU  - Wong ZK
AUID- ORCID: 0009-0000-0081-3915
AD  - Navy Medical Service, Republic of Singapore Navy, Singapore.
AD  - Corresponding author: Dr Zebedee KR Wong, Navy Medical Service, Republic of 
      Singapore Navy, Singapore, zebwong@gmail.com.
FAU - Teo, Colin Ka
AU  - Teo CK
AD  - Navy Medical Service, Republic of Singapore Navy, Singapore.
FAU - Kwek, James Wm
AU  - Kwek JW
AD  - Navy Medical Service, Republic of Singapore Navy, Singapore.
FAU - Kim, Soo Joang
AU  - Kim SJ
AD  - Hyperbaric and Diving Medicine Centre, Singapore General Hospital, Singapore.
FAU - See, Hooi Geok
AU  - See HG
AD  - Division of Anaesthesiology and Perioperative Medicine, Singapore General 
      Hospital, Singapore.
LA  - eng
PT  - Case Reports
PT  - Review
PL  - Australia
TA  - Diving Hyperb Med
JT  - Diving and hyperbaric medicine
JID - 101282742
RN  - 7U1EE4V452 (Carbon Monoxide)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Humans
MH  - Female
MH  - Adult
MH  - *Hyperbaric Oxygenation/methods
MH  - Carbon Monoxide
MH  - Oxygen
MH  - *Carbon Monoxide Poisoning/complications/therapy/diagnosis
MH  - Brain
OTO - NOTNLM
OT  - Hyperbaric medicine
OT  - Morbidity
OT  - Neurology
OT  - Pain
OT  - Psychology
OT  - Radiological imaging
OT  - Toxicity
EDAT- 2024/03/21 00:44
MHDA- 2024/03/22 06:44
CRDT- 2024/03/20 19:06
PHST- 2023/12/08 00:00 [received]
PHST- 2024/02/03 00:00 [accepted]
PHST- 2024/03/22 06:44 [medline]
PHST- 2024/03/21 00:44 [pubmed]
PHST- 2024/03/20 19:06 [entrez]
AID - 10.28920/dhm54.1.65-68 [doi]
PST - ppublish
SO  - Diving Hyperb Med. 2024 Mar 31;54(1):65-68. doi: 10.28920/dhm54.1.65-68.