PMID- 38509497
OWN - NLM
STAT- MEDLINE
DCOM- 20240322
LR  - 20240323
IS  - 1471-2474 (Electronic)
IS  - 1471-2474 (Linking)
VI  - 25
IP  - 1
DP  - 2024 Mar 21
TI  - Association of sarcopenia with osteoporosis in Chinese patients with type 2 
      diabetes.
PG  - 226
LID - 10.1186/s12891-024-07323-2 [doi]
LID - 226
AB  - BACKGROUND: People with type 2 diabetes mellitus (T2DM) present a higher tendency 
      to develop sarcopenia and osteoporosis compared with the normal population. 
      Currently, osteoporosis screening has been frequently performed among T2DM 
      patients, but sarcopenia screening is relatively less, and the association 
      between the two diseases remains unclear. Herein, this study aims to determine 
      the association between sarcopenia and osteoporosis in Chinese T2DM patients. 
      METHODS: This was a retrospective study of 678 patients with T2DM in the First 
      Affiliated Hospital of Wenzhou Medical University. The bone mineral density (BMD) 
      and muscle mass were measured by using dual-energy X-ray absorptiometry scanning. 
      The diagnostic criteria of sarcopenia referred to the consensus by the Asia 
      Working Group for Sarcopenia (AWGS). RESULT: Among T2DM patients, the proportion 
      of the sarcopenia population complicated with osteoporosis was higher than that 
      of the non-sarcopenia (30.9% vs. 8.6% in men and 46.9% vs. 33.9% in women), but 
      only significantly in men. The BMD of the hip and femoral neck was positively 
      correlated with skeletal muscle mass index (SMI), grip strength, and gait speed 
      (P < 0.01). After adjusting all covariates, the association between sarcopenia 
      and BMD showed odds ratios of 0.43 (95% CI:0.28-0.66) for the femoral neck and 
      0.49 (95% CI:0.32-0.73) for the hip. CONCLUSIONS: The BMD of the hip and femoral 
      neck in T2DM patients is related to sarcopenia-related indicators and represents 
      an independent protective factor for sarcopenia. To reduce the risk of falls, 
      fractures, and weakness, it is necessary to take sarcopenia assessment in people 
      with T2DM and osteopenia/osteoporosis.
CI  - (c) 2024. The Author(s).
FAU - Xu, Ke
AU  - Xu K
AD  - Department of Endocrinology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, 325000, China.
FAU - Feng, Xiaozhen
AU  - Feng X
AD  - Department of Health Care Center, The First Affiliated Hospital of Wenzhou 
      Medical University, Wenzhou, 325000, China.
FAU - Xu, Zeru
AU  - Xu Z
AD  - Department of Endocrinology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, 325000, China.
FAU - Pan, Yang
AU  - Pan Y
AD  - Department of Endocrinology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, 325000, China.
FAU - Zhang, Ping
AU  - Zhang P
AD  - Department of Endocrinology, Xining Second People's Hospital, Xining, 810000, 
      China.
FAU - Zhu, Hong
AU  - Zhu H
AD  - Department of Endocrinology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, 325000, China. zhuhong@wmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20240321
PL  - England
TA  - BMC Musculoskelet Disord
JT  - BMC musculoskeletal disorders
JID - 100968565
SB  - IM
MH  - Male
MH  - Humans
MH  - Female
MH  - *Sarcopenia/diagnostic imaging/epidemiology
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - Retrospective Studies
MH  - *Osteoporosis/diagnostic imaging/epidemiology
MH  - Bone Density/physiology
MH  - Absorptiometry, Photon
MH  - China/epidemiology
PMC - PMC10956338
OTO - NOTNLM
OT  - Osteoporosis
OT  - Sarcopenia
OT  - Type 2 diabetes
COIS- The authors declare that they have no competing interests.
EDAT- 2024/03/21 06:43
MHDA- 2024/03/22 06:44
PMCR- 2024/03/21
CRDT- 2024/03/21 00:45
PHST- 2023/03/08 00:00 [received]
PHST- 2024/02/28 00:00 [accepted]
PHST- 2024/03/22 06:44 [medline]
PHST- 2024/03/21 06:43 [pubmed]
PHST- 2024/03/21 00:45 [entrez]
PHST- 2024/03/21 00:00 [pmc-release]
AID - 10.1186/s12891-024-07323-2 [pii]
AID - 7323 [pii]
AID - 10.1186/s12891-024-07323-2 [doi]
PST - epublish
SO  - BMC Musculoskelet Disord. 2024 Mar 21;25(1):226. doi: 10.1186/s12891-024-07323-2.