PMID- 38509672
OWN - NLM
STAT- Publisher
LR  - 20240321
IS  - 1875-6190 (Electronic)
IS  - 1570-159X (Linking)
DP  - 2024 Mar 20
TI  - Metabotropic Glutamate Receptors Type 3 and 5 Feature the "NeuroTransmitter-type" 
      of Glioblastoma: A Bioinformatic Approach.
LID - 10.2174/1570159X22666240320112926 [doi]
AB  - BACKGROUND: Glioblastoma (GBM) represents an aggressive and common tumor of the 
      central nervous system. The prognosis of GBM is poor, and despite a refined 
      genetic and molecular characterization, pharmacological treatment is largely 
      suboptimal. OBJECTIVE: Contribute to defining a therapeutic line in GBM targeting 
      the mGlu3 receptor in line with the principles of precision medicine. METHODS: 
      Here, we performed a computational analysis focused on the expression of type 3 
      and 5 metabotropic glutamate receptor subtypes (mGlu3 and mGlu5, respectively) in 
      high- and low-grade gliomas. RESULTS: The analysis allowed the identification of 
      a particular high-grade glioma type, characterized by a high expression level of 
      both receptor subtypes and by other markers of excitatory and inhibitory 
      neurotransmission. This so-called neurotransmitter-GBM (NT-GBM) also shows a 
      distinct immunological, metabolic, and vascularization gene signature. 
      CONCLUSION: Our findings might lay the groundwork for a targeted therapy to be 
      specifically applied to this putative novel type of GBM.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Caridi, Matteo
AU  - Caridi M
AD  - Division of Hematology and Clinical Immunology, Department of Medicine, 
      University of Perugia, Perugia, Italy.
FAU - Alborghetti, Marika
AU  - Alborghetti M
AD  - Department of Neuroscience, Mental Health and Sensory Organs, Sapienza University 
      of Rome, Rome.
FAU - Pellicelli, Valeria
AU  - Pellicelli V
AD  - Internal Medicine, Sapienza University of Rome, Rome.
FAU - Orlando, Rosamaria
AU  - Orlando R
AD  - Department of Physiology and Pharmacology, University Sapienza of Roma, Rome, 
      Italy.
AD  - IRCCS Neuromed, Pozzilli, Italy.
FAU - Pontieri, Francesco Ernesto
AU  - Pontieri FE
AD  - Department of Neuroscience, Mental Health and Sensory Organs, Sapienza University 
      of Rome, Rome, Italy.
AD  - IRCCS Neuromed, Pozzilli, Italy.
FAU - Battaglia, Giuseppe
AU  - Battaglia G
AD  - Department of Physiology and Pharmacology, University Sapienza of Roma, Rome, 
      Italy.
AD  - IRCCS Neuromed, Pozzilli, Italy.
FAU - Arcella, Antonietta
AU  - Arcella A
AD  - IRCCS Neuromed, , Italy.
LA  - eng
PT  - Journal Article
DEP - 20240320
PL  - United Arab Emirates
TA  - Curr Neuropharmacol
JT  - Current neuropharmacology
JID - 101157239
SB  - IM
OTO - NOTNLM
OT  - Glioma
OT  - glioblastoma multiforme
OT  - glutamate
OT  - immunological signature
OT  - metabolic signature.
OT  - metabotropic glutamate receptors type 3 and type 5
OT  - neurotransmitter- GBM
EDAT- 2024/03/21 06:42
MHDA- 2024/03/21 06:42
CRDT- 2024/03/21 01:42
PHST- 2023/06/06 00:00 [received]
PHST- 2023/08/11 00:00 [revised]
PHST- 2023/09/01 00:00 [accepted]
PHST- 2024/03/21 06:42 [medline]
PHST- 2024/03/21 06:42 [pubmed]
PHST- 2024/03/21 01:42 [entrez]
AID - CN-EPUB-139298 [pii]
AID - 10.2174/1570159X22666240320112926 [doi]
PST - aheadofprint
SO  - Curr Neuropharmacol. 2024 Mar 20. doi: 10.2174/1570159X22666240320112926.