PMID- 38509725
OWN - NLM
STAT- MEDLINE
DCOM- 20240322
LR  - 20240323
IS  - 1582-4934 (Electronic)
IS  - 1582-1838 (Print)
IS  - 1582-1838 (Linking)
VI  - 28
IP  - 7
DP  - 2024 Apr
TI  - Immune patterns of cuproptosis in ischemic heart failure: A transcriptome 
      analysis.
PG  - e18187
LID - 10.1111/jcmm.18187 [doi]
LID - e18187
AB  - Cuproptosis is a recently discovered programmed cell death pattern that affects 
      the tricarboxylic acid (TCA) cycle by disrupting the lipoylation of pyruvate 
      dehydrogenase (PDH) complex components. However, the role of cuproptosis in the 
      progression of ischemic heart failure (IHF) has not been investigated. In this 
      study, we investigated the expression of 10 cuproptosis-related genes in samples 
      from both healthy individuals and those with IHF. Utilizing these differential 
      gene expressions, we developed a risk prediction model that effectively 
      distinguished healthy and IHF samples. Furthermore, we conducted a comprehensive 
      evaluation of the association between cuproptosis and the immune microenvironment 
      in IHF, encompassing infiltrated immunocytes, immune reaction gene-sets and human 
      leukocyte antigen (HLA) genes. Moreover, we identified two different 
      cuproptosis-mediated expression patterns in IHF and explored the immune 
      characteristics associated with each pattern. In conclusion, this study 
      elucidates the significant influence of cuproptosis on the immune 
      microenvironment in ischemic heart failure (IHF), providing valuable insights for 
      future mechanistic research exploring the association between cuproptosis and 
      IHF.
CI  - (c) 2024 The Authors. Journal of Cellular and Molecular Medicine published by 
      Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.
FAU - Chen, Zhebin
AU  - Chen Z
AD  - Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang 
      University, Hangzhou, People's Republic of China.
AD  - Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of 
      Zhejiang Province, Hangzhou, People's Republic of China.
FAU - Zhu, Yunhui
AU  - Zhu Y
AD  - Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang 
      University, Hangzhou, People's Republic of China.
AD  - Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of 
      Zhejiang Province, Hangzhou, People's Republic of China.
FAU - Chen, Songzan
AU  - Chen S
AD  - Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang 
      University, Hangzhou, People's Republic of China.
AD  - Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of 
      Zhejiang Province, Hangzhou, People's Republic of China.
FAU - Li, Zhengwei
AU  - Li Z
AD  - Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang 
      University, Hangzhou, People's Republic of China.
AD  - Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of 
      Zhejiang Province, Hangzhou, People's Republic of China.
FAU - Fu, Guosheng
AU  - Fu G
AD  - Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang 
      University, Hangzhou, People's Republic of China.
AD  - Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of 
      Zhejiang Province, Hangzhou, People's Republic of China.
FAU - Wang, Yao
AU  - Wang Y
AUID- ORCID: 0000-0003-4115-9571
AD  - Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang 
      University, Hangzhou, People's Republic of China.
AD  - Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of 
      Zhejiang Province, Hangzhou, People's Republic of China.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Cell Mol Med
JT  - Journal of cellular and molecular medicine
JID - 101083777
RN  - 789U1901C5 (Copper)
SB  - IM
MH  - Humans
MH  - *Gene Expression Profiling
MH  - *Heart Failure/genetics
MH  - Apoptosis
MH  - Citric Acid Cycle
MH  - Cytoplasm
MH  - Copper
MH  - Tumor Microenvironment
PMC - PMC10955177
OTO - NOTNLM
OT  - cuproptosis
OT  - immune microenvironment
OT  - immunity
OT  - ischemic heart failure
OT  - transcriptome analysis
COIS- The authors declare that they have no conflict of interest.
EDAT- 2024/03/21 06:43
MHDA- 2024/03/22 06:44
PMCR- 2024/03/20
CRDT- 2024/03/21 02:53
PHST- 2024/01/08 00:00 [revised]
PHST- 2023/07/04 00:00 [received]
PHST- 2024/02/04 00:00 [accepted]
PHST- 2024/03/22 06:44 [medline]
PHST- 2024/03/21 06:43 [pubmed]
PHST- 2024/03/21 02:53 [entrez]
PHST- 2024/03/20 00:00 [pmc-release]
AID - JCMM18187 [pii]
AID - 10.1111/jcmm.18187 [doi]
PST - ppublish
SO  - J Cell Mol Med. 2024 Apr;28(7):e18187. doi: 10.1111/jcmm.18187.