PMID- 38510450
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240322
IS  - 2296-858X (Print)
IS  - 2296-858X (Electronic)
IS  - 2296-858X (Linking)
VI  - 11
DP  - 2024
TI  - Association of intrinsic capacity with functional ability, sarcopenia and 
      systemic inflammation in pre-frail older adults.
PG  - 1374197
LID - 10.3389/fmed.2024.1374197 [doi]
LID - 1374197
AB  - BACKGROUND: Decline in intrinsic capacity (IC) has been shown to accelerate 
      progression to disability. The study aims to explore association of IC composite 
      score with functional ability, sarcopenia and systemic inflammation in pre-frail 
      older adults. METHODS: Cross-sectional study of pre-frail older adults >/=60 years 
      old recruited from the community and primary care centers. Composite scores of 
      four domains of IC were measured: locomotion, vitality, cognition and 
      psychological. FRAIL scale was used to define pre-frailty. Muscle mass was 
      measured using the bioelectrical impedance analysis. Systemic inflammation 
      biomarkers [Interleukin-6 (IL-6), Interleukin-10 (IL-10), Tumor Necrosis Factor 
      Alpha (TNF-alpha), and Growth differentiated factor 15 (GDF-15)] were measured. 
      Participants in the lowest tertile (T1) exhibited greater decline in IC. RESULTS: 
      A total of 398 pre-frail older adults were recruited, mean age was 72.7 +/- 5.8 
      years, 60.1% female, education level 7.8 years, and 85.2% were of Chinese 
      ethnicity. A total of 75.1% had decline in locomotion, 40.5% in vitality, 53.2% 
      in cognition and 41.7% in psychological domain. A total of 95% had decline in at 
      least one domain. T1 was significantly associated with ADL impairment (aOR 3.36, 
      95% CI 1.78-6.32), IADL impairment (aOR 2.37, 95% CI 1.36-4.13), poor perceived 
      health (aOR 0.96, 95% CI 0.95-0.98), fall (aOR 1.63, 95% CI 1.05-2.84), cognitive 
      impairment (aOR 8.21, 95% CI 4.69-14.39), depression (aOR 101.82, 95% CI 
      33.62-308.37), and sarcopenia (aOR 2.40, 95% CI 1.60-5.45). T1 had significant 
      associations with GDF-15, IL-10, and IL-10 to TNF-alpha ratio. CONCLUSION: Decline in 
      IC composite score among pre-frail older adults was associated with functional 
      limitation, sarcopenia, and systemic inflammation.
CI  - Copyright (c) 2024 Merchant, Chan, Anbarasan and Vellas.
FAU - Merchant, Reshma Aziz
AU  - Merchant RA
AD  - Division of Geriatric Medicine, Department of Medicine, National University 
      Hospital, Singapore, Singapore.
AD  - Department of Medicine, Yong Loo Lin School of Medicine, National University of 
      Singapore, Singapore, Singapore.
FAU - Chan, Yiong Huak
AU  - Chan YH
AD  - Biostatistics Unit, Yong Loo Lin School of Medicine, National University of 
      Singapore, Singapore, Singapore.
FAU - Anbarasan, Denishkrshna
AU  - Anbarasan D
AD  - Department of Medicine, Yong Loo Lin School of Medicine, National University of 
      Singapore, Singapore, Singapore.
FAU - Vellas, Bruno
AU  - Vellas B
AD  - Gerontopole, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.
LA  - eng
PT  - Journal Article
DEP - 20240306
PL  - Switzerland
TA  - Front Med (Lausanne)
JT  - Frontiers in medicine
JID - 101648047
PMC - PMC10953915
OTO - NOTNLM
OT  - growth differentiation factor 15
OT  - intrinsic capacity
OT  - pre-frail older adults
OT  - sarcopenia
OT  - systemic inflammation
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2024/03/21 06:43
MHDA- 2024/03/21 06:44
PMCR- 2024/03/06
CRDT- 2024/03/21 04:09
PHST- 2024/01/21 00:00 [received]
PHST- 2024/02/20 00:00 [accepted]
PHST- 2024/03/21 06:44 [medline]
PHST- 2024/03/21 06:43 [pubmed]
PHST- 2024/03/21 04:09 [entrez]
PHST- 2024/03/06 00:00 [pmc-release]
AID - 10.3389/fmed.2024.1374197 [doi]
PST - epublish
SO  - Front Med (Lausanne). 2024 Mar 6;11:1374197. doi: 10.3389/fmed.2024.1374197. 
      eCollection 2024.