PMID- 38511546
OWN - NLM
STAT- Publisher
LR  - 20240325
IS  - 1941-9260 (Electronic)
IS  - 0032-5481 (Linking)
DP  - 2024 Mar 25
TI  - Association between serum ferritin and bone turnover marker levels in type 2 
      diabetes mellitus patients with non-alcoholic fatty liver disease.
PG  - 1-10
LID - 10.1080/00325481.2024.2333718 [doi]
AB  - OBJECTIVE: To investigate the correlation between serum ferritin (SF) and bone 
      turnover markers in type 2 diabetes mellitus (T2DM) patients with non-alcoholic 
      fatty liver disease (NAFLD). METHODS: Seven hundred and forty-two people with 
      T2DM were selected. Serum bone turnover markers: osteocalcin (OC), type I 
      procollagen N-terminal peptide (PINP), beta-I type collagen carboxy-terminal peptide 
      (beta-CTx), and 25-hydroxyvitamin D3 (25-[OH]-D) levels were detected. High SF (HF) 
      was defined as the indicated SF levels above 400 ng/mL in males and more than 
      150 ng/mL in females. Patients were divided into four groups: T2DM+normal SF 
      (non-HF); T2DM+high SF (HF); T2DM+NAFLD+non-HF; andT2DM+NAFLD+HF. Relationships 
      between SF and bone turnover markers were analyzed. RESULTS: Compared with the 
      T2DM+non-HF group, beta-CTx levels were higher in the T2DM+HFgroup. Compared with 
      the T2DM+NAFLD+non-HF group, beta-CTx levels were increased and 25-(OH)-D levels 
      decreased in the T2DM+NAFLD+HF group (all p < 0.05). SF was positively correlated 
      with beta-CTx [beta = 0.074; 95% CI (0.003, 0.205)] and negatively correlated with 
      25-(OH)-D [beta=-0.108; 95%CI (-0.006, -0.001)]. Compared with the T2DM+non-HF 
      group, an independent positive correlation was found between beta-CTx and SF in the 
      T2DM+NAFLD+HF group [OR = 1.002; 95% CI (1.001, 1.004)]. Among males, SF was 
      positively correlatedwith beta-CTx [beta = 0.114; 95% CI (0.031, 0.266)]. SF was 
      negatively correlated with 25-(OH)-D levels in both male and female patients 
      [beta=-0.124; 95% CI (0.007,0.001) and beta=-0.168; 95% CI (-0.012, -0.002)]. Among 
      those >50 years of age and postmenopausal females, SF was negatively correlated 
      with 25-(OH)-D levels [beta=-0.117; 95% CI (-0.007, -0.001) and beta=-0.003; 95% CI 
      (-0.013, -0.003)]. CONCLUSION: SF level was positively correlated with beta-CTx in 
      T2DM patients with NAFLD, which may promote bone resorption and increase the risk 
      of bone loss.
FAU - Chen, Chongyang
AU  - Chen C
AUID- ORCID: 0000-0002-3370-5408
AD  - The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
FAU - Zhao, Yangting
AU  - Zhao Y
AUID- ORCID: 0009-0004-8267-5999
AD  - The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
FAU - Lv, Xiaoyu
AU  - Lv X
AUID- ORCID: 0000-0003-1491-6506
AD  - The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
FAU - Li, Kai
AU  - Li K
AUID- ORCID: 0009-0004-1744-676X
AD  - The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
FAU - Wang, Yawen
AU  - Wang Y
AUID- ORCID: 0009-0007-2667-0941
AD  - The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
FAU - Ma, Dengrong
AU  - Ma D
AUID- ORCID: 0009-0004-1439-9611
AD  - The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
FAU - Han, Mei
AU  - Han M
AUID- ORCID: 0009-0004-7185-158X
AD  - The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
FAU - Zan, Xiaohui
AU  - Zan X
AUID- ORCID: 0009-0008-8475-6417
AD  - The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
FAU - Guo, Xinyuan
AU  - Guo X
AUID- ORCID: 0009-0002-2050-6028
AD  - The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
FAU - Liu, Jingfang
AU  - Liu J
AUID- ORCID: 0000-0003-1908-4454
AD  - The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
AD  - Department of Endocrinology, The First Hospital of Lanzhou University, Lanzhou, 
      Gansu, China.
LA  - eng
PT  - Journal Article
DEP - 20240325
PL  - England
TA  - Postgrad Med
JT  - Postgraduate medicine
JID - 0401147
SB  - IM
OTO - NOTNLM
OT  - 25-hydroxyvitamin D
OT  - Type 2 diabetes mellitus
OT  - bone turnover markers
OT  - non-alcoholic fatty liver disease
OT  - serum ferritin
EDAT- 2024/03/21 12:43
MHDA- 2024/03/21 12:43
CRDT- 2024/03/21 06:33
PHST- 2024/03/21 12:43 [pubmed]
PHST- 2024/03/21 12:43 [medline]
PHST- 2024/03/21 06:33 [entrez]
AID - 10.1080/00325481.2024.2333718 [doi]
PST - aheadofprint
SO  - Postgrad Med. 2024 Mar 25:1-10. doi: 10.1080/00325481.2024.2333718.