PMID- 38511554
OWN - NLM
STAT- MEDLINE
DCOM- 20240322
LR  - 20240322
IS  - 1096-9071 (Electronic)
IS  - 0146-6615 (Linking)
VI  - 96
IP  - 3
DP  - 2024 Mar
TI  - Temporal changes in biomarkers of neutrophil extracellular traps and 
      NET-promoting autoantibodies following adenovirus-vectored, mRNA, and recombinant 
      protein COVID-19 vaccination.
PG  - e29556
LID - 10.1002/jmv.29556 [doi]
AB  - Neutrophil extracellular traps (NETs) play a role in innate pathogen defense and 
      also trigger B-cell response by providing antigens. NETs have been linked to 
      vaccine-induced thrombotic thrombocytopenia. We postulated a potential link 
      between NET biomarkers, NET-promoting autoantibodies, and adverse events (AEs) 
      after COVID-19 vaccine boosters. Healthy donors (HDs) who received ChAdOx1-S (A), 
      mRNA-1273 (M), or recombinant protein (MVC-COV1901) vaccines at the National 
      Taiwan University Hospital between 2021 and 2022 were recruited. We measured 
      serial NET-associated biomarkers, citrullinated-histone3 (citH3), and 
      myeloperoxidase (MPO)-DNA. Serum citH3 and MPO-DNA were significantly or 
      numerically higher in HDs who reported AEs (n = 100, booster Day 0/Day 30, 
      p = 0.01/p = 0.03 and p = 0.30/p = 0.35, respectively). We also observed a 
      positive correlation between rash occurrence in online diaries and elevated 
      citH3. A linear mixed model also revealed significantly higher citH3 levels in 
      mRNA-1273/ChAdOx1-S recipients than MVC-COV1901 recipients. Significant positive 
      correlations were observed between the ratios of anti-heparin platelet factor 4 
      and citH3 levels on Booster Day 0 and naive and between the ratios of anti-NET 
      IgM and citH3 on Booster Day 30/Day 0 in the AA-M and MM-M group, respectively. 
      The increased levels of citH3/MPO-DNA accompanied by NET-promoting autoantibodies 
      suggest a potential connection between mRNA-1273/ChAdOx1-S vaccines and 
      cardiovascular complications. These findings provide insights for risk 
      assessments of future vaccines.
CI  - (c) 2024 Wiley Periodicals LLC.
FAU - Kuo, Yu-Min
AU  - Kuo YM
AUID- ORCID: 0000-0002-5797-6093
AD  - Department of Internal Medicine, Division of Allergy, Immunology and 
      Rheumatology, National Taiwan University, Taipei, Taiwan.
AD  - Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan 
      University, Taipei, Taiwan.
FAU - Kang, Chun-Min
AU  - Kang CM
AD  - Department of Laboratory Medicine, National Taiwan University, Taipei, Taiwan.
FAU - Lai, Zhi-Yun
AU  - Lai ZY
AD  - Department of Microbiology and Immunology, School of Medicine, College of 
      Medicine, Taipei Medical University, Taipei, Taiwan.
FAU - Huang, Ting-Yu
AU  - Huang TY
AD  - Department of Internal Medicine, Division of Infection, National Taiwan 
      University, Taipei, Taiwan.
FAU - Tzeng, Shiang-Jong
AU  - Tzeng SJ
AUID- ORCID: 0000-0003-1633-020X
AD  - Department and Graduate Institute of Pharmacology, College of Medicine, National 
      Taiwan University, Taipei, Taiwan.
FAU - Hsu, Chih-Chieh
AU  - Hsu CC
AD  - Department of Internal Medicine, Division of Infection, National Taiwan 
      University, Taipei, Taiwan.
FAU - Chen, Shey-Ying
AU  - Chen SY
AUID- ORCID: 0000-0002-5855-6170
AD  - Department of Emergency Medicine, National Taiwan University Hospital, National 
      Taiwan University College of Medicine, Taipei, Taiwan.
FAU - Hsieh, Song-Chou
AU  - Hsieh SC
AD  - Department of Internal Medicine, Division of Allergy, Immunology and 
      Rheumatology, National Taiwan University, Taipei, Taiwan.
FAU - Chia, Jean-San
AU  - Chia JS
AD  - Department of Dentistry, National Taiwan University Hospital, National Taiwan 
      University College of Medicine, Taipei, Taiwan.
FAU - Jung, Chiau-Jing
AU  - Jung CJ
AUID- ORCID: 0000-0002-7824-3454
AD  - Department of Microbiology and Immunology, School of Medicine, College of 
      Medicine, Taipei Medical University, Taipei, Taiwan.
FAU - Hsueh, Po-Ren
AU  - Hsueh PR
AUID- ORCID: 0000-0002-7502-9225
AD  - Departments of Laboratory Medicine and Internal Medicine, China Medical 
      University Hospital, China Medical University, Taichung, Taiwan.
AD  - Departments of Laboratory Medicine and Internal Medicine, National Taiwan 
      University Hospital, National Taiwan University, Taipei, Taiwan.
LA  - eng
GR  - NTUH 112-M0024/National Taiwan University Hospital/
GR  - Taiwan Centers for Disease Control/
GR  - NSTC 112-2320-B-038-055-MY3/National Science and Technology Council of Taiwan/
GR  - NSTC112-2320-B-038-061/National Science and Technology Council of Taiwan/
PT  - Journal Article
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
RN  - 0 (COVID-19 Vaccines)
RN  - 0 (Autoantibodies)
RN  - EPK39PL4R4 (2019-nCoV Vaccine mRNA-1273)
RN  - 0 (RNA, Messenger)
RN  - 0 (Biomarkers)
RN  - B5S3K2V0G8 (ChAdOx1 nCoV-19)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Humans
MH  - *Extracellular Traps/metabolism
MH  - COVID-19 Vaccines/adverse effects
MH  - Autoantibodies
MH  - 2019-nCoV Vaccine mRNA-1273
MH  - RNA, Messenger/genetics/metabolism
MH  - *COVID-19/prevention & control/metabolism
MH  - Biomarkers
MH  - ChAdOx1 nCoV-19
MH  - Vaccination
MH  - DNA/metabolism
MH  - Adenoviridae
OTO - NOTNLM
OT  - ChAdOx1 nCoV-19
OT  - MVC-COV1901 vaccine
OT  - autoantibodies
OT  - mRNA-1273.211
OT  - neutrophil extracellular traps
EDAT- 2024/03/21 12:43
MHDA- 2024/03/22 06:45
CRDT- 2024/03/21 06:43
PHST- 2024/03/01 00:00 [revised]
PHST- 2023/11/08 00:00 [received]
PHST- 2024/03/12 00:00 [accepted]
PHST- 2024/03/22 06:45 [medline]
PHST- 2024/03/21 12:43 [pubmed]
PHST- 2024/03/21 06:43 [entrez]
AID - 10.1002/jmv.29556 [doi]
PST - ppublish
SO  - J Med Virol. 2024 Mar;96(3):e29556. doi: 10.1002/jmv.29556.