PMID- 38513531 OWN - NLM STAT- MEDLINE DCOM- 20240329 LR - 20240329 IS - 1090-2414 (Electronic) IS - 0147-6513 (Linking) VI - 274 DP - 2024 Apr 1 TI - Exploring the impact of prenatal perfluoroalkyl and polyfluoroalkyl substances exposure on blood pressure in early childhood: A longitudinal analysis. PG - 116220 LID - S0147-6513(24)00296-3 [pii] LID - 10.1016/j.ecoenv.2024.116220 [doi] AB - Previous research investigating the correlation between prenatal exposure to per- and polyfluoroalkyl substances (PFAS) and subsequent blood pressure (BP) in offspring has yielded limited and contradictory findings. This study was conducted to investigate the potential relationship between maternal PFAS levels during pregnancy and subsequent BP in early childhood. A total of 129 expectant mothers from the Shanghai Birth Cohort were included in the study. Using high-performance liquid chromatography/tandem mass spectrometry, we measured ten PFAS compounds in maternal plasma throughout the pregnancy. When the children reached the age of 4, we examined their systolic BP (SBP) and diastolic BP (DBP), along with mean arterial pressure (MAP) and pulse pressure (PP). Data interpretation employed multiple linear and logistic regression models, complemented by Bayesian kernel machine regression (BKMR).We found that the majority of PFAS concentrations remained stable during pregnancy. The linear and BKMR models indicated a positive relationship between the PFAS mixture in maternal plasma and offspring's DBP and MAP, with perfluorohexanesulphonic acid (PFHxS) having the most significant influence (PFHxS and DBP [first trimester:beta=3.03, 95%CI: (1.01,5.05); second trimester: beta=2.35, 95%CI: (0.94,3.75); third trimester: beta=2.57, 95%CI:(0.80,4.34)]; MAP [first trimester:beta=2.55, 95%CI: (0.64,4.45); second trimester: beta=2.28, 95%CI: (0.95,3.61); third trimester: beta=2.35, 95%CI:(0.68,4.01)]). Logistic regression highlighted an increased risk of prehypertension and hypertension in offspring with higher maternal PFHxS concentrations during all three trimesters [first trimester: OR=2.53, 95%CI:(1.11,5.79), second trimester: OR=2.05, 95%CI:(1.11,3.78), third trimester: OR=3.08, 95%CI:(1.40,6.79)]. A positive correlation was identified between the half-lives of PFAS and the odds ratio (OR) of prehypertension and hypertension in childhood (beta=0.139, P=0.010). In conclusion, this research found maternal plasma PFAS concentrations to be positively associated with BP in offspring, with PFHxS showing the most significant influence. This correlation remained consistent throughout pregnancy, and this effect was proportional to the half-lives of PFAS. CI - Copyright (c) 2024. Published by Elsevier Inc. FAU - Du, Bowen AU - Du B AD - Department of Pediatric Cardiology, Xinhua Hospital Affiliated To Shanghai Jiao Tong University School of Medicine, No.1665, Kongjiang Road, Yangpu District, Shanghai 200092,China. FAU - Wang, Qianchuo AU - Wang Q AD - Department of Pediatric Cardiology, Xinhua Hospital Affiliated To Shanghai Jiao Tong University School of Medicine, No.1665, Kongjiang Road, Yangpu District, Shanghai 200092,China. FAU - Xu, Zhikang AU - Xu Z AD - Department of Pediatric Cardiology, Xinhua Hospital Affiliated To Shanghai Jiao Tong University School of Medicine, No.1665, Kongjiang Road, Yangpu District, Shanghai 200092,China; Institute For Development And Regenerative Cardiovascular Medicine, Xinhua Hospital Affiliated To Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Wang, Hualin AU - Wang H AD - Department of Pediatric Cardiology, Xinhua Hospital Affiliated To Shanghai Jiao Tong University School of Medicine, No.1665, Kongjiang Road, Yangpu District, Shanghai 200092,China. FAU - Li, Zhuoyan AU - Li Z AD - Department of Pediatric Cardiology, Xinhua Hospital Affiliated To Shanghai Jiao Tong University School of Medicine, No.1665, Kongjiang Road, Yangpu District, Shanghai 200092,China; Institute For Development And Regenerative Cardiovascular Medicine, Xinhua Hospital Affiliated To Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Wu, Yujian AU - Wu Y AD - Department of Pediatric Cardiology, Xinhua Hospital Affiliated To Shanghai Jiao Tong University School of Medicine, No.1665, Kongjiang Road, Yangpu District, Shanghai 200092,China. FAU - Niu, Yiwei AU - Niu Y AD - Department of Pediatric Cardiology, Xinhua Hospital Affiliated To Shanghai Jiao Tong University School of Medicine, No.1665, Kongjiang Road, Yangpu District, Shanghai 200092,China. FAU - Zhang, Qianlong AU - Zhang Q AD - Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Zhang, Xi AU - Zhang X AD - Clinical Research Unit, Xinhua Hospital Affiliated To Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Sun, Kun AU - Sun K AD - Department of Pediatric Cardiology, Xinhua Hospital Affiliated To Shanghai Jiao Tong University School of Medicine, No.1665, Kongjiang Road, Yangpu District, Shanghai 200092,China; Institute For Development And Regenerative Cardiovascular Medicine, Xinhua Hospital Affiliated To Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Wang, Jian AU - Wang J AD - Department of Pediatric Cardiology, Xinhua Hospital Affiliated To Shanghai Jiao Tong University School of Medicine, No.1665, Kongjiang Road, Yangpu District, Shanghai 200092,China; Institute For Development And Regenerative Cardiovascular Medicine, Xinhua Hospital Affiliated To Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: wangjian@xinhuamed.com.cn. LA - eng PT - Journal Article DEP - 20240321 PL - Netherlands TA - Ecotoxicol Environ Saf JT - Ecotoxicology and environmental safety JID - 7805381 RN - 0 (Environmental Pollutants) RN - 0 (Fluorocarbons) RN - 0 (Alkanesulfonic Acids) SB - IM MH - Child MH - Pregnancy MH - Female MH - Humans MH - Child, Preschool MH - Blood Pressure MH - *Prehypertension/chemically induced MH - Bayes Theorem MH - *Environmental Pollutants/toxicity MH - *Fluorocarbons/toxicity MH - China MH - *Hypertension/chemically induced MH - *Alkanesulfonic Acids/toxicity OTO - NOTNLM OT - Birth Cohort OT - Blood Pressure OT - Perfluoroalkyl and Polyfluoroalkyl Substances OT - Prenatal Exposure COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/03/22 00:44 MHDA- 2024/03/29 06:46 CRDT- 2024/03/21 19:12 PHST- 2023/10/07 00:00 [received] PHST- 2024/03/12 00:00 [revised] PHST- 2024/03/13 00:00 [accepted] PHST- 2024/03/29 06:46 [medline] PHST- 2024/03/22 00:44 [pubmed] PHST- 2024/03/21 19:12 [entrez] AID - S0147-6513(24)00296-3 [pii] AID - 10.1016/j.ecoenv.2024.116220 [doi] PST - ppublish SO - Ecotoxicol Environ Saf. 2024 Apr 1;274:116220. doi: 10.1016/j.ecoenv.2024.116220. Epub 2024 Mar 21.