PMID- 38513936
OWN - NLM
STAT- MEDLINE
DCOM- 20240408
LR  - 20240408
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 827
DP  - 2024 Mar 28
TI  - Reorganization of structural brain networks in Parkinson's disease with postural 
      instability/gait difficulty.
PG  - 137736
LID - S0304-3940(24)00113-7 [pii]
LID - 10.1016/j.neulet.2024.137736 [doi]
AB  - The Postural Instability/Gait Difficulty (PIGD) subtype of Parkinson's disease 
      (PD) has a faster disease progression, a higher risk of cognitive and motor 
      decline, yet the alterations of structural topological organization remain 
      unknown. Diffusion Tensor Imaging (DTI) and 3D-TI scanning were conducted on 31 
      PD patients with PIGD (PD-PIGD), 30 PD patients without PIGD (PD-non-PIGD) and 35 
      Healthy Controls (HCs). Structural networks were constructed using DTI brain 
      white matter fiber tractography. A graph theory approach was applied to 
      characterize the topological properties of complex structural networks, and the 
      relationships between significantly different network metrics and motor deficits 
      were analyzed within the PD-PIGD group. PD-PIGD patients exhibited increased 
      shortest path length compared with PD-non-PIGD and HCs (P < 0.05, respectively). 
      Additionally, PD-PIGD patients exhibited decreased nodal properties, mainly in 
      the cerebellar vermis, prefrontal cortex, paracentral lobule, and visual regions. 
      Notably, the degree centrality of the cerebellar vermis was negatively correlated 
      with the PIGD score (r = -0.390; P = 0.030) and Unified Parkinson's Disease 
      Rating Scale Part III score (r = -0.436; P = 0.014) in PD-PIGD patients. 
      Furthermore, network-based statistical analysis revealed decreased structural 
      connectivity between the prefrontal lobe, putamen, supplementary motor area, 
      insula, and cingulate gyrus in PD-PIGD patients. Our findings demonstrated that 
      PD-PIGD patients existed abnormal structural connectomes in the cerebellar 
      vermis, frontal-parietal cortex and visual regions. These topological differences 
      can provide a topological perspective for understanding the potential 
      pathophysiological mechanisms of PIGD in PD.
CI  - Copyright (c) 2024 Elsevier B.V. All rights reserved.
FAU - Li, Zihan
AU  - Li Z
AD  - Department of Radiology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing, China.
FAU - Liu, Jun
AU  - Liu J
AD  - Department of Radiology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing, China.
FAU - Miao, Xinxin
AU  - Miao X
AD  - Department of Radiology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing, China.
FAU - Ge, Shaoyun
AU  - Ge S
AD  - Department of Radiology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing, China.
FAU - Shen, Jun
AU  - Shen J
AD  - Department of Radiology, Taizhou Fourth People's Hospital, Taizhou, China.
FAU - Jin, Shaohua
AU  - Jin S
AD  - Department of Radiology, The Affiliated Jiangsu Shengze Hospital of Nanjing 
      Medical University, Suzhou, China.
FAU - Gu, Zhengxue
AU  - Gu Z
AD  - Department of Radiology, Nanjing Central Hospital, Nanjing, China.
FAU - Jia, Yongfeng
AU  - Jia Y
AD  - Department of Radiology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing, China.
FAU - Zhang, Kezhong
AU  - Zhang K
AD  - Department of Neurology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing, China.
FAU - Wang, Jianwei
AU  - Wang J
AD  - Department of Radiology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing, China. Electronic address: wjw19821225@163.com.
FAU - Wang, Min
AU  - Wang M
AD  - Department of Radiology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing, China. Electronic address: jsphwangmin@njmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20240319
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
SB  - IM
MH  - Humans
MH  - *Parkinson Disease/diagnostic imaging
MH  - Diffusion Tensor Imaging
MH  - Magnetic Resonance Imaging/methods
MH  - *Gait Disorders, Neurologic
MH  - Brain/diagnostic imaging
MH  - *Motor Cortex
MH  - Gait
MH  - Postural Balance/physiology
OTO - NOTNLM
OT  - Diffusion tensor imaging
OT  - Parkinson's disease
OT  - Postural instability/gait difficulty
OT  - Structural network
OT  - Topology
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2024/03/22 00:44
MHDA- 2024/04/08 06:43
CRDT- 2024/03/21 20:29
PHST- 2023/10/14 00:00 [received]
PHST- 2024/03/17 00:00 [revised]
PHST- 2024/03/18 00:00 [accepted]
PHST- 2024/04/08 06:43 [medline]
PHST- 2024/03/22 00:44 [pubmed]
PHST- 2024/03/21 20:29 [entrez]
AID - S0304-3940(24)00113-7 [pii]
AID - 10.1016/j.neulet.2024.137736 [doi]
PST - ppublish
SO  - Neurosci Lett. 2024 Mar 28;827:137736. doi: 10.1016/j.neulet.2024.137736. Epub 
      2024 Mar 19.