PMID- 38514590
OWN - NLM
STAT- Publisher
LR  - 20240322
IS  - 1559-0100 (Electronic)
IS  - 1355-008X (Linking)
DP  - 2024 Mar 21
TI  - Dietary composition and time in range in population with type 2 diabetes 
      mellitus-exploring the association using continuous glucose monitoring device.
LID - 10.1007/s12020-024-03787-3 [doi]
AB  - AIM: To understand the association between macronutrient composition of a diet 
      with Time in Range (TIR), Time above Range (TAR) and Time below Range (TBR) 
      derived using a Continuous Glucose Monitoring (CGM) device for 14 days. 
      METHODOLOGY: An exploratory analysis on the baseline data of 50 Type 2 Diabetes 
      Mellitus participants with age 25-55 years, HbA1c upto 8% and on Metformin only) 
      enrolled for an interventional clinical trial was performed. RESULTS: 
      Participants consuming adequate carbohydrates (CHO) of 55 to 60% of total 
      calories had better Average Blood Glucose of 142.0 +/- 24.0 mg/dL with a 
      significance of p = 0.03 and Glucose Management Indicator (GMI) of 6.6 +/- 0.7% 
      significant at p = 0.01, than those with high CHO intake >60% of the total 
      calories, with Average Blood Glucose - 155.0 +/- 13.4 mg/dL and GMI - 7.06 +/- 0.4%. 
      Similarly, TIR - 68.2 +/- 5.1% and TAR - 23.0 +/- 10.8% was significantly better 
      (p = 0.00) among those consuming adequate protein (12-15%) as compared to low 
      protein (</= 10%) with TIR- 61.0 +/- 5.1% & TAR- 32.9 +/- 10.3%. A correlation 
      (r = -0.482 & p = 0.00) and simple linear regression analysis (R(2) = 0.33, 
      F = 7.72, p = 0.000) revealed that when CHO intake increases the TIR decreases 
      whereas TAR increases (r = 0.380 & p = 0.006). We did not find any significant 
      relation between fat intake and TIR, TAR or TBR. CONCLUSION: Our results suggest 
      that lowering CHO, while increasing protein in the diet may help improve TIR. 
      Further in-depth studies are needed to confirm these findings.
CI  - (c) 2024. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Deshmane, Aditi R
AU  - Deshmane AR
AUID- ORCID: 0000-0003-2913-331X
AD  - Nutrition and Dietetics Department, Symbiosis International (Deemed University), 
      Hill Base, Lavale, Pune, Maharashtra, 412115, India.
AD  - Indian Institute of Food Science and Technology, Clinical Nutrition and 
      Dietetics, Augrangabad, Maharashtra, 431005, India.
FAU - Muley, Arti S
AU  - Muley AS
AUID- ORCID: 0000-0001-9131-327X
AD  - Nutrition and Dietetics Department, Symbiosis International (Deemed University), 
      Hill Base, Lavale, Pune, Maharashtra, 412115, India. asmuley@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20240321
PL  - United States
TA  - Endocrine
JT  - Endocrine
JID - 9434444
SB  - IM
OTO - NOTNLM
OT  - Continuous glucose monitoring system
OT  - Diet composition
OT  - Glycemic variability
OT  - Macronutrients
OT  - Time in range
OT  - Type 2 diabetes
EDAT- 2024/03/22 06:44
MHDA- 2024/03/22 06:44
CRDT- 2024/03/22 00:17
PHST- 2023/11/01 00:00 [received]
PHST- 2024/03/14 00:00 [accepted]
PHST- 2024/03/22 06:44 [medline]
PHST- 2024/03/22 06:44 [pubmed]
PHST- 2024/03/22 00:17 [entrez]
AID - 10.1007/s12020-024-03787-3 [pii]
AID - 10.1007/s12020-024-03787-3 [doi]
PST - aheadofprint
SO  - Endocrine. 2024 Mar 21. doi: 10.1007/s12020-024-03787-3.