PMID- 38515610
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240323
IS  - 2452-199X (Electronic)
IS  - 2452-199X (Linking)
VI  - 37
DP  - 2024 Jul
TI  - Dual elemental doping activated signaling pathway of angiogenesis and defective 
      heterojunction engineering for effective therapy of MRSA-infected wounds.
PG  - 14-29
LID - 10.1016/j.bioactmat.2024.03.011 [doi]
AB  - Multi-drug resistant bacterial infections pose a significant threat to human 
      health. Thus, the development of effective bactericidal strategies is a pressing 
      concern. In this study, a ternary heterostructure (Zn-CN/P-GO/BiS) comprised of 
      Zn-doped graphite phase carbon nitride (g-C(3)N(4)), phosphorous-doped graphene 
      oxide (GO) and bismuth sulphide (Bi(2)S(3)) is constructed for efficiently 
      treating methicillin-resistant Staphylococcus aureus (MRSA)-infected wound. Zn 
      doping-induced defect sites in g-C(3)N(4) results in a reduced band gap (DeltaE) and 
      a smaller energy gap (DeltaE(ST)) between the singlet state S(1) and triplet state 
      T(1), which favours two-photon excitation and accelerates electron transfer. 
      Furthermore, the formation of an internal electric field at the ternary 
      heterogeneous interface optimizes the charge transfer pathway, inhibits the 
      recombination of electron-hole pairs, improves the photodynamic effect of 
      g-C(3)N(4), and enhances its catalytic performance. Therefore, the Zn-CN/P-GO/BiS 
      significantly augments the production of reactive oxygen species and heat under 
      808 nm NIR (0.67 W cm(-2)) irradiation, leading to the elimination of 
      99.60% +/- 0.07% MRSA within 20 min. Additionally, the release of essential trace 
      elements (Zn and P) promotes wound healing by activating hypoxia-inducible 
      factor-1 (HIF-1) and peroxisome proliferator-activated receptors (PPAR) signaling 
      pathways. This work provides unique insight into the rapid antibacterial 
      applications of trace element doping and two-photon excitation.
CI  - (c) 2024 The Authors.
FAU - Huang, Jin
AU  - Huang J
AD  - Biomedical Materials Engineering Research Center, Hubei Key Laboratory of Polymer 
      Materials, Ministry-of-Education Key Laboratory for the Green Preparation and 
      Application of Functional Materials, School of Materials Science & Engineering, 
      Hubei University, Wuhan, 430062, China.
AD  - School of Health Science & Biomedical Engineering, Hebei University of 
      Technology, Tianjin, 300401, China.
AD  - School of Materials Science & Engineering, Peking University, Beijing, 100871, 
      China.
FAU - Wu, Shuilin
AU  - Wu S
AD  - Biomedical Materials Engineering Research Center, Hubei Key Laboratory of Polymer 
      Materials, Ministry-of-Education Key Laboratory for the Green Preparation and 
      Application of Functional Materials, School of Materials Science & Engineering, 
      Hubei University, Wuhan, 430062, China.
AD  - School of Materials Science & Engineering, Peking University, Beijing, 100871, 
      China.
FAU - Wang, Yi
AU  - Wang Y
AD  - Biomedical Materials Engineering Research Center, Hubei Key Laboratory of Polymer 
      Materials, Ministry-of-Education Key Laboratory for the Green Preparation and 
      Application of Functional Materials, School of Materials Science & Engineering, 
      Hubei University, Wuhan, 430062, China.
AD  - School of Health Science & Biomedical Engineering, Hebei University of 
      Technology, Tianjin, 300401, China.
AD  - School of Materials Science & Engineering, Peking University, Beijing, 100871, 
      China.
FAU - Shen, Jie
AU  - Shen J
AD  - Shenzhen Key Laboratory of Spine Surgery, Department of Spine Surgery, Peking 
      University Shenzhen Hospital, Shenzhen, 518036, China.
FAU - Wang, Chaofeng
AU  - Wang C
AD  - School of Health Science & Biomedical Engineering, Hebei University of 
      Technology, Tianjin, 300401, China.
FAU - Zheng, Yufeng
AU  - Zheng Y
AD  - School of Materials Science & Engineering, Peking University, Beijing, 100871, 
      China.
FAU - Chu, Paul K
AU  - Chu PK
AD  - Department of Physics and Department of Materials Science and Engineering, City 
      University of Hong Kong, 999077, China.
FAU - Liu, Xiangmei
AU  - Liu X
AD  - Biomedical Materials Engineering Research Center, Hubei Key Laboratory of Polymer 
      Materials, Ministry-of-Education Key Laboratory for the Green Preparation and 
      Application of Functional Materials, School of Materials Science & Engineering, 
      Hubei University, Wuhan, 430062, China.
AD  - School of Health Science & Biomedical Engineering, Hebei University of 
      Technology, Tianjin, 300401, China.
LA  - eng
PT  - Journal Article
DEP - 20240314
PL  - China
TA  - Bioact Mater
JT  - Bioactive materials
JID - 101685294
PMC - PMC10951428
OTO - NOTNLM
OT  - Defective heterojunction engineering
OT  - Methicillin-resistant Staphylococcus aureus
OT  - Phototherapy
OT  - Signaling pathways
OT  - Wound healing
COIS- The authors declare no conflict of interest.
EDAT- 2024/03/22 06:45
MHDA- 2024/03/22 06:46
PMCR- 2024/03/14
CRDT- 2024/03/22 03:57
PHST- 2024/02/16 00:00 [received]
PHST- 2024/03/05 00:00 [revised]
PHST- 2024/03/08 00:00 [accepted]
PHST- 2024/03/22 06:46 [medline]
PHST- 2024/03/22 06:45 [pubmed]
PHST- 2024/03/22 03:57 [entrez]
PHST- 2024/03/14 00:00 [pmc-release]
AID - S2452-199X(24)00092-6 [pii]
AID - 10.1016/j.bioactmat.2024.03.011 [doi]
PST - epublish
SO  - Bioact Mater. 2024 Mar 14;37:14-29. doi: 10.1016/j.bioactmat.2024.03.011. 
      eCollection 2024 Jul.