PMID- 3851620
OWN - NLM
STAT- MEDLINE
DCOM- 19851219
LR  - 20131121
IS  - 0231-4622 (Print)
IS  - 0231-4622 (Linking)
VI  - 32
IP  - 2
DP  - 1985
TI  - Pathogenicity and virulence of methicillin resistant Staphylococcus aureus: slime 
      layer production.
PG  - 155-65
AB  - Nine methicillin-resistant (MR) mutants and three methicillin-sensitive (MS) 
      substrains, all derived from naturally occurring heteroresistant isolates of 
      Staphylococcus aureus were examined for slime production. All strains showed an 
      increased mucoid character when cultured on a modified Staphylococcus Medium No. 
      110. The uranic acid content of the slime layer ranged from 2% to 6% in the MR 
      mutants and from 1.3% to 5.1% in the MS substrains. The amount of uronic acid per 
      g of dry bacteria ranged from 82.5 mg to 143.8 mg in the MR mutants, and between 
      51.4 mg and 98.8 mg in the MS substrains. In 3 pairs of MR mutants and MS 
      substrains originating from the same parents, the MR cells possessed more of 
      uronic acid than their MS counterparts. The partially purified polysaccharide 
      part of the slime contained D-galactose, D-mannose, D-xylose, D-galacturonic 
      acid, D-galactosamine and D-glucuronic acid in all strains studied. Its 
      quantitative composition was identical in each pair of the MR mutant and MS 
      substrain; there were, however, considerable differences among the strains and 
      between the pairs. Methicillin resistance and slime formation seem to be 
      independent properties in S. aureus. The presumable significance of the readiness 
      of slime production by MR cocci during infections is discussed.
FAU - Rozgonyi, F
AU  - Rozgonyi F
FAU - Seltmann, G
AU  - Seltmann G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Hungary
TA  - Acta Microbiol Hung
JT  - Acta microbiologica Hungarica
JID - 8400270
RN  - 0 (Anti-Bacterial Agents)
RN  - Q91FH1328A (Methicillin)
SB  - IM
MH  - Anti-Bacterial Agents/pharmacology
MH  - Humans
MH  - Methicillin/*pharmacology
MH  - Penicillin Resistance
MH  - Species Specificity
MH  - Staphylococcal Infections/microbiology
MH  - Staphylococcus aureus/drug effects/growth & development/isolation & 
      purification/*pathogenicity
MH  - Virulence
EDAT- 1985/01/01 00:00
MHDA- 1985/01/01 00:01
CRDT- 1985/01/01 00:00
PHST- 1985/01/01 00:00 [pubmed]
PHST- 1985/01/01 00:01 [medline]
PHST- 1985/01/01 00:00 [entrez]
PST - ppublish
SO  - Acta Microbiol Hung. 1985;32(2):155-65.