PMID- 38516222 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240323 IS - 2772-6533 (Electronic) IS - 2772-6533 (Linking) VI - 4 DP - 2024 Jun TI - Health and illness beliefs in adults with tuberculosis infection during the COVID-19 pandemic in the UK. PG - 100162 LID - 10.1016/j.dialog.2023.100162 [doi] LID - 100162 AB - BACKGROUND: COVID-19 disrupted the TB prevention programme in the UK, especially for TB infection (TBI) care. We explore whether experience of the COVID-19 pandemic impacted on patients' perceptions of TBI and its treatment. METHODS: Semi-structured interviews were conducted as part of the Research to Improve Detection and Treatment of TBI (RID-TB) programme, exploring perceptual and practical barriers to TBI treatment. Nineteen people diagnosed with TBI were interviewed between August 2020 and April 2021. Recordings were transcribed and analysed using a constant comparative approach, allowing for a dynamic and iterative exploration of themes. Themes are organised using the Perceptions and Practicalities Approach. FINDINGS: Some participants perceived TBI as a risk factor for increased susceptibility to COVID-19, while some thought that treatment for TBI might protect against COVID-19 or mitigate its effects. Adaptations to TB services (e.g., remote follow-up) and integrated practices during the COVID-19 restrictions (e.g., medication being posted) addressed some practical barriers to TBI treatment. However, we identified beliefs about TBI and COVID-19 that are likely to act as barriers to engagement with TBI treatment, including: interpreting service delays as an indication of TBI not being serious enough for treatment and concerns about contracting COVID-19 in TB clinics. INTERPRETATION: COVID-19 and TBI service delays influence people's perceptions and practical barriers to TBI treatment adherence. Failure to address these beliefs may lead to people's concerns about their treatment not being fully addressed. Utilised service adaptations like remote consultations to address practical barriers may be relevant beyond COVID-19. FUNDING: NIHR RID-TB Program (RP-PG-0217-20009). CI - (c) 2023 Published by Elsevier Inc. CC BY-NC-ND 4.0. FAU - Kilic, Aysenur AU - Kilic A AD - School of Pharmacy, University College London, London, UK. FAU - Clarke, Amy L AU - Clarke AL AD - School of Pharmacy, University College London, London, UK. FAU - Moon, Zoe AU - Moon Z AD - School of Pharmacy, University College London, London, UK. FAU - Hamada, Yohhei AU - Hamada Y AD - Institute for Global Health, University College London, London, UK. FAU - Chan, Amy Hai Yan AU - Chan AHY AD - School of Pharmacy, University of Auckland, Auckland, New Zealand. FAU - Rahman, Ananna AU - Rahman A AD - Department of Respiratory Medicine, Barts Health NHS Trust, London, UK. FAU - Layton, Charlotte AU - Layton C AD - MRC Clinical Trials Unit, University College London, UK. FAU - Griffiths, Chris J AU - Griffiths CJ AD - Centre for Primary Care, Wolfson Institute of Population Health, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK. FAU - Zenner, Dominik AU - Zenner D AD - Centre for Primary Care, Wolfson Institute of Population Health, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK. FAU - Powell, Ellen AU - Powell E AD - MRC Clinical Trials Unit, University College London, UK. FAU - Kunst, Heinke AU - Kunst H AD - Respiratory Medicine, Queen Mary University of London, London, UK. FAU - Lipman, Marc AU - Lipman M AD - Royal Free London NHS Foundation Trust, London, UK. AD - UCL-TB and UCL Respiratory, University College London, London, UK. FAU - Mandelbaum, Mike AU - Mandelbaum M AD - TB Alert, Brighton, UK. FAU - Papineni, Padmasayee AU - Papineni P AD - London Northwest University Healthcare NHS Trust, London, UK. FAU - Tattersall, Tessa AU - Tattersall T AD - MRC Clinical Trials Unit, University College London, UK. FAU - Duong, Trinh AU - Duong T AD - MRC Clinical Trials Unit, University College London, UK. FAU - Abubakar, Ibrahim AU - Abubakar I AD - Institute for Global Health, University College London, London, UK. FAU - Rangaka, Molebogeng X AU - Rangaka MX AD - Institute for Global Health, University College London, London, UK. AD - Division of Epidemiology and Biostatistics & CIDRI-AFRICA, University of Cape Town, Cape Town, South Africa. FAU - Horne, Robert AU - Horne R AD - School of Pharmacy, University College London, London, UK. LA - eng PT - Journal Article DEP - 20231129 PL - United States TA - Dialogues Health JT - Dialogues in health JID - 9918506184906676 PMC - PMC10953974 OTO - NOTNLM OT - Covid-19 OT - LTBI OT - health beliefs OT - perceptions OT - tuberculosis COIS- None. EDAT- 2024/03/22 06:44 MHDA- 2024/03/22 06:45 PMCR- 2023/11/29 CRDT- 2024/03/22 04:07 PHST- 2023/08/08 00:00 [received] PHST- 2023/11/23 00:00 [revised] PHST- 2023/11/27 00:00 [accepted] PHST- 2024/03/22 06:45 [medline] PHST- 2024/03/22 06:44 [pubmed] PHST- 2024/03/22 04:07 [entrez] PHST- 2023/11/29 00:00 [pmc-release] AID - S2772-6533(23)00066-7 [pii] AID - 100162 [pii] AID - 10.1016/j.dialog.2023.100162 [doi] PST - epublish SO - Dialogues Health. 2023 Nov 29;4:100162. doi: 10.1016/j.dialog.2023.100162. eCollection 2024 Jun.